6U7I
 
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6USS
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6UST
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1RR8
 | | Structural Mechanisms of Camptothecin Resistance by Mutations in Human Topoisomerase I | | 分子名称: | (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE, 2-(1-DIMETHYLAMINOMETHYL-2-HYDROXY-8-HYDROXYMETHYL-9-OXO-9,11-DIHYDRO-INDOLIZINO[1,2-B]QUINOLIN-7-YL)-2-HYDROXY-BUTYRIC ACID, 5'-D(*AP*AP*AP*AP*AP*GP*AP*CP*TP*T*GP*GP*AP*AP*AP*AP*AP*TP*TP*TP*TP*T)-3', ... | | 著者 | Chrencik, J.E, Staker, B.L, Burgin, A.B, Stewart, L, Redinbo, M.R. | | 登録日 | 2003-12-08 | | 公開日 | 2004-07-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Mechanisms of camptothecin resistance by human topoisomerase I mutations
J.Mol.Biol., 339, 2004
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1SKX
 | | Structural Disorder in the Complex of Human PXR and the Macrolide Antibiotic Rifampicin | | 分子名称: | Orphan nuclear receptor PXR, RIFAMPICIN | | 著者 | Chrencik, J.E, Xue, Y, Orans, J.O, Redinbo, M.R. | | 登録日 | 2004-03-05 | | 公開日 | 2005-03-08 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Structural disorder in the complex of human pregnane x receptor and the macrolide antibiotic rifampicin
Mol.Endocrinol., 19, 2005
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4K59
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2H7C
 | | Crystal structure of human carboxylesterase in complex with Coenzyme A | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, COENZYME A, ... | | 著者 | Bencharit, S, Edwards, C.C, Morton, C.L, Howard-Williams, E.L, Potter, P.M, Redinbo, M.R. | | 登録日 | 2006-06-02 | | 公開日 | 2006-08-29 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Multisite promiscuity in the processing of endogenous substrates by human carboxylesterase 1
J.Mol.Biol., 363, 2006
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2HRR
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2HRQ
 | | Crystal structure of Human Liver Carboxylesterase 1 (hCE1) in covalent complex with the nerve agent Soman (GD) | | 分子名称: | (1R)-1,2,2-TRIMETHYLPROPYL (R)-METHYLPHOSPHINATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Liver carboxylesterase 1, ... | | 著者 | Fleming, C.D, Redinbo, M.R. | | 登録日 | 2006-07-20 | | 公開日 | 2007-05-01 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal Structures of Human Carboxylesterase 1 in Covalent Complexes with the Chemical Warfare Agents Soman and Tabun.
Biochemistry, 46, 2007
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3LPF
 | | Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 1-((6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea | | 分子名称: | 1-[(6,7-dimethyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]-1-(2-hydroxyethyl)-3-(3-methoxyphenyl)thiourea, Beta-glucuronidase | | 著者 | Wallace, B.D, Redinbo, M.R. | | 登録日 | 2010-02-05 | | 公開日 | 2010-11-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.26 Å) | | 主引用文献 | Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.
Science, 330, 2010
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3LPG
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3MBO
 | | Crystal Structure of the Glycosyltransferase BaBshA bound with UDP and L-malate | | 分子名称: | D-MALATE, GLYCEROL, Glycosyltransferase, ... | | 著者 | Wallace, B.D, Claiborne, A, Redinbo, M.R. | | 登録日 | 2010-03-25 | | 公開日 | 2010-09-29 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.307 Å) | | 主引用文献 | Characterization of the N-Acetyl-alpha-d-glucosaminyl
l-Malate Synthase and Deacetylase Functions for Bacillithiol Biosynthesis
in Bacillus anthracis
Biochemistry, 49, 2010
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8ESI
 | | Bile Salt Hydrolase from B. longum with covalent inhibitor bound | | 分子名称: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Conjugated bile acid hydrolase | | 著者 | Walker, M.E, Lim, L, Redinbo, M.R. | | 登録日 | 2022-10-14 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8ETF
 | | Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | | 分子名称: | (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION | | 著者 | Walker, M.E, Redinbo, M.R. | | 登録日 | 2022-10-17 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8ESG
 | | Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | | 分子名称: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase | | 著者 | Walker, M.E, Redinbo, M.R. | | 登録日 | 2022-10-14 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.18 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8ETK
 | | Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe | | 分子名称: | (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-(2-{2-[(prop-2-yn-1-yl)oxy]ethoxy}ethoxy)hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION | | 著者 | Walker, M.E, Grundy, M.K, Redinbo, M.R. | | 登録日 | 2022-10-17 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.83 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8ETE
 | | Bile Salt Hydrolase from B. longum with covalent inhibitor bound | | 分子名称: | (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Conjugated bile acid hydrolase | | 著者 | Walker, M.E, Redinbo, M.R. | | 登録日 | 2022-10-17 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8ESL
 | | Bile Salt Hydrolase from a Bacteroidales species with covalent inhibitor bound | | 分子名称: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase | | 著者 | Walker, M.E, Redinbo, M.R. | | 登録日 | 2022-10-14 | | 公開日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.11 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8EWT
 | | Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe | | 分子名称: | (5R)-5-{(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-[(prop-2-yn-1-yl)oxy]hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl}-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION | | 著者 | Walker, M.E, Redinbo, M.R. | | 登録日 | 2022-10-24 | | 公開日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8FAO
 | | Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | | 分子名称: | (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11S,11aR)-7,11-dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION | | 著者 | Grundy, M.K, Walker, M.E, Redinbo, M.R. | | 登録日 | 2022-11-28 | | 公開日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity
To Be Published
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8GES
 | | R. hominis 2 beta-glucuronidase bound to UNC10201652-glucuronide | | 分子名称: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | | 著者 | Simpson, J.B, Redinbo, M.R. | | 登録日 | 2023-03-07 | | 公開日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes
To Be Published
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8GEQ
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8GEN
 | | E. eligens beta-glucuronidase bound to UNC10201652-glucuronide | | 分子名称: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase | | 著者 | Simpson, J.B, Redinbo, M.R. | | 登録日 | 2023-03-07 | | 公開日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | Diverse Human Therapeutics Impact Hormone and Neurotransmitter Homeostasis by Inhibiting Gut Microbial Enzymes
To Be Published
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8GET
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8GEO
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