5OFK
 
 | | Crystal structure of CbXyn10C variant E140Q/E248Q complexed with xyloheptaose | | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Glycoside hydrolase family 48, PIPERAZINE-N,N'-BIS(2-ETHANESULFONIC ACID), ... | | 著者 | Hakulinen, N, Penttinen, L, Rouvinen, J, Tu, T. | | 登録日 | 2017-07-11 | | 公開日 | 2017-10-04 | | 最終更新日 | 2024-05-08 | | 実験手法 | X-RAY DIFFRACTION (1.16 Å) | | 主引用文献 | Insights into the roles of non-catalytic residues in the active site of a GH10 xylanase with activity on cellulose.
J. Biol. Chem., 292, 2017
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5KV9
 | | Crystal structure of a hPIV haemagglutinin-neuraminidase-inhibitor complex | | 分子名称: | 1,2-ETHANEDIOL, 2,6-anhydro-3,4,5-trideoxy-5-[(2-methylpropanoyl)amino]-4-(4-phenyl-1H-1,2,3-triazol-1-yl)-D-glycero-D-galacto-non-2-en onic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Dirr, L, El-Deeb, I.M, Chavas, L.M.G, Guillon, P, von Itzstein, M. | | 登録日 | 2016-07-13 | | 公開日 | 2017-07-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The impact of the butterfly effect on human parainfluenza virus haemagglutinin-neuraminidase inhibitor design.
Sci Rep, 7, 2017
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5L1O
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7CP9
 | | Cryo-EM structure of human mitochondrial translocase TOM complex at 3.0 angstrom. | | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Mitochondrial import receptor subunit TOM22 homolog, Mitochondrial import receptor subunit TOM40 homolog, ... | | 著者 | Guan, Z, Yan, L, Wang, Q, Yan, C, Yin, P. | | 登録日 | 2020-08-06 | | 公開日 | 2021-04-28 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural insights into assembly of human mitochondrial translocase TOM complex.
Cell Discov, 7, 2021
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5OHJ
 | | Human phosphodiesterase 4B catalytic domain in complex with a pyrrolidinyl inhibitor. | | 分子名称: | MAGNESIUM ION, ZINC ION, [(1~{S})-2-[3,5-bis(chloranyl)-1-oxidanyl-pyridin-1-ium-4-yl]-1-[4-[bis(fluoranyl)methoxy]-3-(cyclopropylmethoxy)phenyl]ethyl] (2~{S})-1-[3-(dimethylcarbamoyl)phenyl]sulfonylpyrrolidine-2-carboxylate, ... | | 著者 | Rizzi, A, Carzaniga, L, Armani, E. | | 登録日 | 2017-07-17 | | 公開日 | 2017-12-13 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Discovery and Optimization of Thiazolidinyl and Pyrrolidinyl Derivatives as Inhaled PDE4 Inhibitors for Respiratory Diseases.
J. Med. Chem., 60, 2017
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2B1P
 | | inhibitor complex of JNK3 | | 分子名称: | 3-{6-[(2-CHLOROPHENYL)AMINO]-1H-INDAZOL-3-YL}-5-{[4-(DIMETHYLAMINO)BUTANOYL]AMINO}BENZOIC ACID, BETA-MERCAPTOETHANOL, Mitogen-activated protein kinase 10, ... | | 著者 | Swahn, B.M, Huerta, F, Kallin, E, Malmstrom, J, Weigelt, T, Viklund, J, Womack, P, Xue, Y, Ohberg, L. | | 登録日 | 2005-09-16 | | 公開日 | 2006-09-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Design and synthesis of 6-anilinoindazoles as selective inhibitors of c-Jun N-terminal kinase-3
Bioorg.Med.Chem.Lett., 15, 2005
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4RZ6
 | | Transaldolase B E96Q F178Y from E.coli | | 分子名称: | CHLORIDE ION, HEXAETHYLENE GLYCOL, SULFATE ION, ... | | 著者 | Stellmacher, L, Sandalova, T, Leptihn, S, Schneider, G, Sprenger, G.A, Samland, A.K. | | 登録日 | 2014-12-18 | | 公開日 | 2015-10-07 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Acid Base Catalyst Discriminates between a Fructose 6-Phosphate Aldolase and a Transaldolase
ChemCatChem, 2015
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5KYB
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5KYK
 | | Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs | | 分子名称: | 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine, GTPase KRas | | 著者 | Xiong, Y, Lu, J, Hunter, J, Li, L, Scott, D, Manandhar, A, Gondi, S, Westover, K.D, Gray, N.S. | | 登録日 | 2016-07-21 | | 公開日 | 2017-04-12 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (2.702 Å) | | 主引用文献 | Covalent Guanosine Mimetic Inhibitors of G12C KRAS.
ACS Med Chem Lett, 8, 2017
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1CMZ
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2B2G
 | | MS2 Wild-type RNA stemloop complexed with an N87S mutant MS2 capsid | | 分子名称: | 5'-R(*AP*CP*AP*UP*GP*AP*GP*GP*AP*UP*UP*AP*CP*CP*CP*AP*UP*GP*U)-3', Coat protein | | 著者 | Horn, W.T, Tars, K, Grahn, E, Helgstrand, C, Baron, A.J, Lago, H, Adams, C.J, Peabody, D.S, Phillips, S.E.V, Stonehouse, N.J, Liljas, L, Stockley, P.G. | | 登録日 | 2005-09-19 | | 公開日 | 2006-05-09 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (3.02 Å) | | 主引用文献 | Structural basis of RNA binding discrimination between bacteriophages Qbeta and MS2
Structure, 14, 2006
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5KZF
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2B3O
 | | Crystal structure of human tyrosine phosphatase SHP-1 | | 分子名称: | Tyrosine-protein phosphatase, non-receptor type 6 | | 著者 | Yang, J, Liu, L, He, D, Song, X, Liang, X, Zhao, Z.J, Zhou, G.W. | | 登録日 | 2005-09-20 | | 公開日 | 2005-10-25 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Crystal structure of human protein-tyrosine phosphatase SHP-1.
J.Biol.Chem., 278, 2003
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2ANN
 | | Crystal structure (I) of Nova-1 KH1/KH2 domain tandem with 25 nt RNA hairpin | | 分子名称: | 5'-R(*CP*GP*CP*GP*CP*GP*GP*AP*UP*CP*AP*GP*UP*CP*AP*CP*CP*CP*AP*AP*GP*CP*GP*CP*G)-3', MAGNESIUM ION, POTASSIUM ION, ... | | 著者 | Malinina, L, Teplova, M, Musunuru, K, Teplov, A, Darnell, J.C, Burley, S.K, Darnell, R.B, Patel, D.J. | | 登録日 | 2005-08-11 | | 公開日 | 2006-10-24 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
Structure, 19, 2011
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4ZHM
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7ULG
 | | recombinant alpha cobra toxin | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, Alpha-cobratoxin | | 著者 | Xu, J, Lei, X, Chen, L. | | 登録日 | 2022-04-04 | | 公開日 | 2023-05-03 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | | 主引用文献 | Structure of recombinant alpha cobra toxin at 1.57 Angstroms
To Be Published
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7ULR
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5L1Q
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7ULS
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5L7I
 | | Structure of human Smoothened in complex with Vismodegib | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-chloranyl-~{N}-(4-chloranyl-3-pyridin-2-yl-phenyl)-4-methylsulfonyl-benzamide, SODIUM ION, ... | | 著者 | Byrne, E.X.B, Sircar, R, Miller, P.S, Hedger, G, Luchetti, G, Nachtergaele, S, Tully, M.D, Mydock-McGrane, L, Covey, D.F, Rambo, R.F, Sansom, M.S.P, Newstead, S, Rohatgi, R, Siebold, C. | | 登録日 | 2016-06-03 | | 公開日 | 2016-07-20 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structural basis of Smoothened regulation by its extracellular domains.
Nature, 535, 2016
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2AOH
 | | Crystal structure analysis of HIV-1 Protease mutant V82A with a substrate analog P6-PR | | 分子名称: | CHLORIDE ION, PEPTIDE INHIBITOR, POL POLYPROTEIN, ... | | 著者 | Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Liu, F, Chen, X, Tozser, J, Harrison, R.W, Weber, I.T. | | 登録日 | 2005-08-12 | | 公開日 | 2006-01-17 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | | 主引用文献 | Molecular basis for substrate recognition and drug resistance from 1.1 to 1.6 angstroms resolution crystal structures of HIV-1 protease mutants with substrate analogs.
Febs J., 272, 2005
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2AP1
 | | Crystal structure of the putative regulatory protein | | 分子名称: | SODIUM ION, ZINC ION, putative regulator protein | | 著者 | Brunzelle, J.S, Minasov, G, Shuvalova, L, Collart, F.R, Joachimiak, A, Anderson, W.F, Midwest Center for Structural Genomics (MCSG) | | 登録日 | 2005-08-15 | | 公開日 | 2005-09-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of the putative regulatory protein
To be Published
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4ZKO
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5L9S
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2ATL
 | | Unmodified Insertion Ternary Complex | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*CP*T*AP*AP*CP*GP*CP*TP*AP*CP*CP*AP*TP*CP*CP*AP*AP*CP*C)-3', 5'-D(*GP*GP*TP*TP*GP*GP*AP*TP*GP*GP*TP*AP*(DDG))-3', ... | | 著者 | Rechkoblit, O, Malinina, L, Cheng, Y, Kuryavyi, V, Broyde, S, Geacintov, N.E, Patel, D.J. | | 登録日 | 2005-08-25 | | 公開日 | 2006-01-10 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Stepwise Translocation of Dpo4 Polymerase during Error-Free Bypass of an oxoG Lesion
Plos Biol., 4, 2006
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