Crystal structure (I) of Nova-1 KH1/KH2 domain tandem with 25 nt RNA hairpin

Summary for 2ANN

Descriptor5'-R(*CP*GP*CP*GP*CP*GP*GP*AP*UP*CP*AP*GP*UP*CP*AP*CP*CP*CP*AP*AP*GP*CP*GP*CP*G)-3', neuro-oncological ventral antigen 1, POTASSIUM ION, ... (5 entities in total)
Functional Keywordsprotein-rna complex, rna-binding protein-rna complex, rna-binding protein/rna
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total molecular weight27303.62
Malinina, L.,Teplova, M.,Musunuru, K.,Teplov, A.,Darnell, J.C.,Burley, S.K.,Darnell, R.B.,Patel, D.J. (deposition date: 2005-08-11, release date: 2006-10-24, Last modification date: 2017-10-11)
Primary citation
Teplova, M.,Malinina, L.,Darnell, J.C.,Song, J.,Lu, M.,Abagyan, R.,Musunuru, K.,Teplov, A.,Burley, S.K.,Darnell, R.B.,Patel, D.J.
Protein-RNA and protein-protein recognition by dual KH1/2 domains of the neuronal splicing factor Nova-1.
Structure, 19:930-944, 2011
PubMed: 21742260 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2011.05.002
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.248100.7%20.7%2.9%0.67MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 2ann
no rotation
Molmil generated image of 2ann
rotated about x axis by 90°
Molmil generated image of 2ann
rotated about y axis by 90°