5KYK
Covalent GTP-competitive inhibitors of KRAS G12C: Guanosine bisphosphonate Analogs
Summary for 5KYK
Entry DOI | 10.2210/pdb5kyk/pdb |
Descriptor | GTPase KRas, 5'-O-[(R)-[({2-[(chloroacetyl)amino]ethyl}sulfamoyl)methyl](hydroxy)phosphoryl]guanosine (3 entities in total) |
Functional Keywords | kras, cancer, covalent inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (Human) |
Cellular location | Cell membrane ; Lipid-anchor ; Cytoplasmic side : P01116 |
Total number of polymer chains | 3 |
Total formula weight | 59416.80 |
Authors | Xiong, Y.,Lu, J.,Hunter, J.,Li, L.,Scott, D.,Manandhar, A.,Gondi, S.,Westover, K.D.,Gray, N.S. (deposition date: 2016-07-21, release date: 2017-04-12, Last modification date: 2023-10-04) |
Primary citation | Xiong, Y.,Lu, J.,Hunter, J.,Li, L.,Scott, D.,Choi, H.G.,Lim, S.M.,Manandhar, A.,Gondi, S.,Sim, T.,Westover, K.D.,Gray, N.S. Covalent Guanosine Mimetic Inhibitors of G12C KRAS. ACS Med Chem Lett, 8:61-66, 2017 Cited by PubMed: 28105276DOI: 10.1021/acsmedchemlett.6b00373 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.702 Å) |
Structure validation
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