5Y0V
 
 | | Crystal Structure of insect beta-N-acetyl-D-hexosaminidase OfHex1 complexed with berberine | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, BERBERINE, ... | | 著者 | Duan, Y.W, Liu, T, Tang, J.Y, Li, M, Yang, Q. | | 登録日 | 2017-07-18 | | 公開日 | 2018-01-24 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.423 Å) | | 主引用文献 | Glycoside hydrolase family 18 and 20 enzymes are novel targets of the traditional medicine berberine.
J. Biol. Chem., 293, 2018
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7WEF
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7WE9
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8U7X
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8U7W
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7WLC
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7WED
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7WEA
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7WEC
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7WE8
 | | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv265 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 265, ... | | 著者 | Wang, X, Wang, L. | | 登録日 | 2021-12-23 | | 公開日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.
Nature, 603, 2022
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7WE7
 | | SARS-CoV-2 Omicron variant spike protein in complex with Fab XGv282 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of Fab 282, ... | | 著者 | Wang, X, Wang, L. | | 登録日 | 2021-12-23 | | 公開日 | 2022-05-04 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Memory B cell repertoire from triple vaccinees against diverse SARS-CoV-2 variants.
Nature, 603, 2022
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7WEB
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7WEE
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8WD0
 | | Crystal structure of T2R-TTL-Erianin complex | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol, CALCIUM ION, ... | | 著者 | Yang, J. | | 登録日 | 2023-09-14 | | 公開日 | 2024-07-03 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | The cytotoxic natural compound erianin binds to colchicine site of beta-tubulin and overcomes taxane resistance
Bioorg.Chem., 150, 2024
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5VRL
 | | CRYSTAL STRUCTURE OF THE INHA FROM MYCOBACTERIUM TUBERCULOSIS IN COMPLEX WITH AN12855, EBSI 4333. | | 分子名称: | (~{N}~{E})-~{N}-[[2-[[2-ethylsulfonyl-1,1-bis(oxidanyl)-3,4-dihydro-2,3,1$l^{4}-benzodiazaborinin-7-yl]oxy]-5-(trifluoromethyl)phenyl]methylidene]hydroxylamine, Enoyl-[acyl-carrier-protein] reductase [NADH] | | 著者 | Abendroth, J, Edwards, T.E, Lorimer, D. | | 登録日 | 2017-05-11 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Discovery of a cofactor-independent inhibitor ofMycobacterium tuberculosisInhA.
Life Sci Alliance, 1, 2018
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8GXN
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8GXO
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6I3M
 | | eIF2B:eIF2 complex, phosphorylated on eIF2 alpha serine 52. | | 分子名称: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | 著者 | Adomavicius, T, Roseman, A.M, Pavitt, G.D. | | 登録日 | 2018-11-06 | | 公開日 | 2019-05-22 | | 最終更新日 | 2019-11-06 | | 実験手法 | ELECTRON MICROSCOPY (3.93 Å) | | 主引用文献 | The structural basis of translational control by eIF2 phosphorylation.
Nat Commun, 10, 2019
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6I7T
 | | eIF2B:eIF2 complex | | 分子名称: | Eukaryotic translation initiation factor 2 subunit alpha, Eukaryotic translation initiation factor 2 subunit beta, Eukaryotic translation initiation factor 2 subunit gamma, ... | | 著者 | Adomavicius, T, Guaita, M, Roseman, A.M, Pavitt, G.D. | | 登録日 | 2018-11-17 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-05-15 | | 実験手法 | ELECTRON MICROSCOPY (4.61 Å) | | 主引用文献 | The structural basis of translational control by eIF2 phosphorylation.
Nat Commun, 10, 2019
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8HIT
 | | Crystal structure of anti-CTLA-4 humanized IgG1 MAb--JS007 in complex with human CTLA-4 | | 分子名称: | Cytotoxic T-lymphocyte protein 4, JS007-VH, JS007-VL | | 著者 | Tan, S, Shi, Y, Wang, Q, Gao, G.F, Guan, J, Chai, Y, Qi, J. | | 登録日 | 2022-11-21 | | 公開日 | 2023-02-01 | | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | | 主引用文献 | Characterization of the high-affinity anti-CTLA-4 monoclonal antibody JS007 for immune checkpoint therapy of cancer.
Mabs, 15, 2023
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6IEG
 | | Crystal structure of human MTR4 | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Exosome RNA helicase MTR4, MAGNESIUM ION | | 著者 | Chen, J.Y, Yun, C.H. | | 登録日 | 2018-09-14 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.55 Å) | | 主引用文献 | NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
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7VEH
 | | Type I-F Anti-CRISPR protein AcrIF13 | | 分子名称: | AcrIF13 | | 著者 | Gao, T, Feng, Y. | | 登録日 | 2021-09-08 | | 公開日 | 2022-07-06 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Mechanistic insights into the inhibition of the CRISPR-Cas surveillance complex by anti-CRISPR protein AcrIF13.
J.Biol.Chem., 298, 2022
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6IEH
 | | Crystal structures of the hMTR4-NRDE2 complex | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, Exosome RNA helicase MTR4, ... | | 著者 | Chen, J.Y, Yun, C.H. | | 登録日 | 2018-09-14 | | 公開日 | 2019-04-03 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.892 Å) | | 主引用文献 | NRDE2 negatively regulates exosome functions by inhibiting MTR4 recruitment and exosome interaction.
Genes Dev., 33, 2019
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7V1N
 | | Structure of the Clade 2 C. difficile TcdB in complex with its receptor TFPI | | 分子名称: | Isoform Beta of Tissue factor pathway inhibitor, Toxin B | | 著者 | Luo, J, Yang, Q, Zhang, X, Zhang, Y, Wan, L, Li, Y, Tao, L. | | 登録日 | 2021-08-05 | | 公開日 | 2022-02-23 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | TFPI is a colonic crypt receptor for TcdB from hypervirulent clade 2 C. difficile.
Cell, 185, 2022
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7VF6
 | | The crystal structure of PurZ0 | | 分子名称: | GLYCEROL, GUANOSINE-5'-DIPHOSPHATE, PHOSPHATE ION, ... | | 著者 | Tong, Y, Zhang, Y. | | 登録日 | 2021-09-10 | | 公開日 | 2023-05-24 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | | 主引用文献 | Alternative Z-genome biosynthesis pathway shows evolutionary progression from Archaea to phage.
Nat Microbiol, 8, 2023
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