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3VSH
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Crystal structure of native 1,6-APD (with Iron), 2-Animophenol-1,6-Dioxygenase
分子名称: 2-amino-5-chlorophenol 1,6-dioxygenase alpha subunit, 2-amino-5-chlorophenol 1,6-dioxygenase beta subunit, FE (II) ION
著者Li, D.F, Hou, Y.J, Hu, Y, Wang, D.C, Liu, W.
登録日2012-04-25
公開日2013-01-16
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structures of aminophenol dioxygenase in complex with intermediate, product and inhibitor
Acta Crystallogr.,Sect.D, 69, 2013
3LKZ
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Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase
分子名称: GLYCEROL, Non-structural protein 5, SINEFUNGIN
著者Liu, L.H, Li, H.M.
登録日2010-01-28
公開日2010-08-04
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and functional analyses of a conserved hydrophobic pocket of flavivirus methyltransferase.
J.Biol.Chem., 285, 2010
6L42
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Structure of severe fever with thrombocytopenia syndrome virus L protein
分子名称: MAGNESIUM ION, RNA polymerase
著者Wang, P, Lou, Z.
登録日2019-10-15
公開日2020-05-13
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Structure of severe fever with thrombocytopenia syndrome virus L protein elucidates the mechanisms of viral transcription initiation.
Nat Microbiol, 5, 2020
6E8E
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BU of 6e8e by Molmil
Crystal structure of the Escherichia coli sliding clamp-MutL complex.
分子名称: Beta sliding clamp,DNA mismatch repair protein MutL, GLYCEROL, SULFATE ION
著者Guarne, A, Almawi, A.W.
登録日2018-07-28
公開日2019-05-01
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Binding of the regulatory domain of MutL to the sliding beta-clamp is species specific.
Nucleic Acids Res., 47, 2019
6E8D
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BU of 6e8d by Molmil
Crystal structure of the Bacillus subtilis sliding clamp-MutL complex.
分子名称: Beta sliding clamp,DNA mismatch repair protein MutL, GLYCEROL
著者Guarne, A, Almawi, A.W.
登録日2018-07-28
公開日2019-05-01
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献Binding of the regulatory domain of MutL to the sliding beta-clamp is species specific.
Nucleic Acids Res., 47, 2019
6E1A
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BU of 6e1a by Molmil
Menin bound to M-89
分子名称: (1S,2R)-2-[(4S)-2-methyl-4-{1-[(1-{4-[(pyridin-4-yl)sulfonyl]phenyl}azetidin-3-yl)methyl]piperidin-4-yl}-1,2,3,4-tetrahydroisoquinolin-4-yl]cyclopentyl methylcarbamate, Menin, praseodymium triacetate
著者Stuckey, J.A.
登録日2018-07-09
公開日2019-07-10
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Structure-Based Discovery of M-89 as a Highly Potent Inhibitor of the Menin-Mixed Lineage Leukemia (Menin-MLL) Protein-Protein Interaction.
J.Med.Chem., 62, 2019
5H14
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EED in complex with an allosteric PRC2 inhibitor EED666
分子名称: 2-[3-(3,5-dimethylpyrazol-1-yl)-4-nitro-phenyl]-3,4-dihydro-1H-isoquinoline, GLYCEROL, Histone-lysine N-methyltransferase EZH2, ...
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-08
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
5TRF
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MDM2 in complex with SAR405838
分子名称: (2'S,3R,4'S,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2, GLYCEROL, ...
著者Meagher, J.L, Stuckey, J.A.
登録日2016-10-26
公開日2016-11-09
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献SAR405838: an optimized inhibitor of MDM2-p53 interaction that induces complete and durable tumor regression.
Cancer Res., 74, 2014
5H15
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EED in complex with PRC2 allosteric inhibitor EED709
分子名称: (3R,4S)-1-[(2-methoxyphenyl)methyl]-N,N-dimethyl-4-(1-methylindol-3-yl)pyrrolidin-3-amine, Histone-lysine N-methyltransferase EZH2, Polycomb protein EED
著者Zhao, K, Zhao, M, Luo, X, Zhang, H.
登録日2016-10-08
公開日2017-01-25
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.27 Å)
主引用文献Discovery and Molecular Basis of a Diverse Set of Polycomb Repressive Complex 2 Inhibitors Recognition by EED
PLoS ONE, 12, 2017
6MWR
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Recognition of MHC-like molecule
分子名称: 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ...
著者Le Nours, J, Rossjohn, J.
登録日2018-10-30
公開日2019-12-18
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献A class of gamma delta T cell receptors recognize the underside of the antigen-presenting molecule MR1.
Science, 366, 2019
6X5H
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Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP
分子名称: 1,2-ETHANEDIOL, Alpha-(1,6)-fucosyltransferase, GLYCEROL, ...
著者Kadirvelraj, R, Wood, Z.A.
登録日2020-05-26
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
J.Biol.Chem., 295, 2020
6X5S
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Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A3'-Asn
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, A3'-Asn, Alpha-(1,6)-fucosyltransferase, ...
著者Kadirvelraj, R, Wood, Z.A.
登録日2020-05-26
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
J.Biol.Chem., 295, 2020
7THK
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BU of 7thk by Molmil
Cryo-EM structure of prefusion SARS-CoV-2 spike omicron B.1.1.529 variant
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein
著者Cerutti, G, Shapiro, L.
登録日2022-01-11
公開日2022-03-02
最終更新日2022-03-16
実験手法ELECTRON MICROSCOPY (3.11 Å)
主引用文献Cryo-EM structure of the SARS-CoV-2 Omicron spike.
Cell Rep, 38, 2022
6X5R
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Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A2-Asn
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, A2-Asn, ...
著者Kadirvelraj, R, Wood, Z.A.
登録日2020-05-26
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
J.Biol.Chem., 295, 2020
6X5T
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Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and A3-Asn
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alpha-(1,6)-fucosyltransferase, GLYCEROL, ...
著者Kadirvelraj, R, Wood, Z.A.
登録日2020-05-26
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
J.Biol.Chem., 295, 2020
6X5U
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Human Alpha-1,6-fucosyltransferase (FUT8) bound to GDP and NM5M2-Asn
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Kadirvelraj, R, Wood, Z.A.
登録日2020-05-26
公開日2020-10-07
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Characterizing human alpha-1,6-fucosyltransferase (FUT8) substrate specificity and structural similarities with related fucosyltransferases.
J.Biol.Chem., 295, 2020
2YYF
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Purification and structural characterization of a D-amino acid containing conopeptide, marmophine, from Conus marmoreus
分子名称: M-conotoxin mr12
著者Huang, F, Du, W, Han, Y, Wang, C.
登録日2007-04-29
公開日2008-04-08
最終更新日2022-03-16
実験手法SOLUTION NMR
主引用文献Purification and structural characterization of a D-amino acid-containing conopeptide, conomarphin, from Conus marmoreus.
Febs J., 275, 2008
6XQP
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Structure of human D462-E4 TCR in complex with human MR1-5-OP-RU
分子名称: 1-deoxy-1-({2,6-dioxo-5-[(E)-propylideneamino]-1,2,3,6-tetrahydropyrimidin-4-yl}amino)-D-ribitol, BROMIDE ION, Beta-2-microglobulin, ...
著者Awad, W, Rossjohn, J.
登録日2020-07-10
公開日2020-08-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Atypical TRAV1-2 - T cell receptor recognition of the antigen-presenting molecule MR1.
J.Biol.Chem., 295, 2020
6XQQ
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Structure of human D462-E4 TCR
分子名称: GLYCEROL, TRAV12-2 alpha chain, TRBV29-1
著者Awad, W, Rossjohn, J.
登録日2020-07-10
公開日2020-08-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.68 Å)
主引用文献Atypical TRAV1-2 - T cell receptor recognition of the antigen-presenting molecule MR1.
J.Biol.Chem., 295, 2020
7VUZ
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with PAMP-12, state2
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, Y, Yang, F.
登録日2021-11-04
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.89 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VV4
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with linear cortistatin-14, local
分子名称: CHOLESTEROL, Mas-related G-protein coupled receptor member X2, circular cortistatin-14
著者Li, Y, Yang, F.
登録日2021-11-04
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.97 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VDM
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with substance P
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, Y, Yang, F.
登録日2021-09-07
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VV5
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state1
分子名称: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Li, Y, Yang, F.
登録日2021-11-04
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.76 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VDL
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with circular cortistatin-14
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, Y, Yang, F.
登録日2021-09-07
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (3.22 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021
7VDH
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Cryo-EM structure of pseudoallergen receptor MRGPRX2 complex with C48/80, state2
分子名称: 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylamino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]phenyl]-~{N}-methyl-ethanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Li, Y, Yang, F.
登録日2021-09-07
公開日2021-12-01
最終更新日2022-07-20
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Structure, function and pharmacology of human itch receptor complexes.
Nature, 600, 2021

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