2XTJ
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![BU of 2xtj by Molmil](/molmil-images/mine/2xtj) | The crystal structure of PCSK9 in complex with 1D05 Fab | 分子名称: | CALCIUM ION, FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05, ... | 著者 | Di Marco, S, Volpari, C, Carfi, A. | 登録日 | 2010-10-10 | 公開日 | 2010-11-03 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo. J.Lipid Res., 52, 2011
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8TOC
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![BU of 8toc by Molmil](/molmil-images/mine/8toc) | Acinetobacter phage AP205 | 分子名称: | Coat protein, Maturation protein, RNA (4269-MER) | 著者 | Meng, R, Xing, Z, Chang, J, Zhang, J. | 登録日 | 2023-08-03 | 公開日 | 2024-03-06 | 最終更新日 | 2024-04-10 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structural basis of Acinetobacter type IV pili targeting by an RNA virus. Nat Commun, 15, 2024
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8TOB
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6AEJ
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![BU of 6aej by Molmil](/molmil-images/mine/6aej) | Crystal structure of human FTO in complex with small-molecule inhibitors | 分子名称: | (E)-3-[3-nitro-4,5-bis(oxidanyl)phenyl]-2-(1,3-oxazinan-3-ylcarbonyl)prop-2-enenitrile, Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION | 著者 | Wang, Y, Cao, R, Peng, S, Zhang, W, Huang, N. | 登録日 | 2018-08-05 | 公開日 | 2019-06-19 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med, 11, 2019
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6AK4
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![BU of 6ak4 by Molmil](/molmil-images/mine/6ak4) | Crystal structure of human FTO in complex with small-molecule inhibitors | 分子名称: | (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide, Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION | 著者 | Wang, Y, Cao, R, Peng, S, Zhang, W, Huang, N. | 登録日 | 2018-08-30 | 公開日 | 2019-07-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med, 11, 2019
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4G84
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![BU of 4g84 by Molmil](/molmil-images/mine/4g84) | Crystal structure of human HisRS | 分子名称: | CHLORIDE ION, Histidine--tRNA ligase, cytoplasmic, ... | 著者 | Wei, Z, Wu, J, Zhou, J.J, Yang, X.-L, Zhang, M, Schimmel, P. | 登録日 | 2012-07-21 | 公開日 | 2012-09-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing. Structure, 20, 2012
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8WCS
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6C6N
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6C6R
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4U0I
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![BU of 4u0i by Molmil](/molmil-images/mine/4u0i) | Crystal structure of KIT in complex with ponatinib | 分子名称: | 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzam ide, Mast/stem cell growth factor receptor Kit,Mast/stem cell growth factor receptor Kit, PHOSPHATE ION | 著者 | Zhou, T, Zhu, X, Dalgarno, D.C. | 登録日 | 2014-07-11 | 公開日 | 2014-10-08 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Ponatinib Inhibits Polyclonal Drug-Resistant KIT Oncoproteins and Shows Therapeutic Potential in Heavily Pretreated Gastrointestinal Stromal Tumor (GIST) Patients. Clin.Cancer Res., 20, 2014
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8WQW
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![BU of 8wqw by Molmil](/molmil-images/mine/8wqw) | Cryo-EM structure of bsAb3 Fab-Gn-Gc complex | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glycoprotein C, Glycoprotein N, ... | 著者 | Wu, Y, Sun, J.Q. | 登録日 | 2023-10-12 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | 主引用文献 | Bispecific antibodies targeting two glycoproteins on SFTSV exhibit synergistic neutralization and protection in a mouse model. Proc.Natl.Acad.Sci.USA, 121, 2024
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8WCE
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![BU of 8wce by Molmil](/molmil-images/mine/8wce) | Cryo-EM structure of a protein-RNA complex | 分子名称: | MAGNESIUM ION, RNA (31-MER), RNA (66-MER), ... | 著者 | Li, Z. | 登録日 | 2023-09-11 | 公開日 | 2024-05-22 | 最終更新日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (3.09 Å) | 主引用文献 | Molecular mechanism for target RNA recognition and cleavage of Cas13h. Nucleic Acids Res., 52, 2024
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8YDB
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8YB6
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![BU of 8yb6 by Molmil](/molmil-images/mine/8yb6) | Type I-EHNH Cascade complex | 分子名称: | 61-nt crRNA, CRISPR system Cascade subunit CasC, CRISPR system Cascade subunit CasD, ... | 著者 | Li, Z. | 登録日 | 2024-02-11 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Mol.Cell, 2024
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8YHA
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![BU of 8yha by Molmil](/molmil-images/mine/8yha) | Type I-EHNH Cascade-ssDNA complex | 分子名称: | 61-nt crRNA, CRISPR system Cascade subunit CasC, CRISPR system Cascade subunit CasD, ... | 著者 | Li, Z. | 登録日 | 2024-02-27 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Mol.Cell, 2024
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8YH9
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![BU of 8yh9 by Molmil](/molmil-images/mine/8yh9) | Type I-FHNH Cascade complex | 分子名称: | 60-nt crRNA, Cas5f, Cas6f, ... | 著者 | Li, Z. | 登録日 | 2024-02-27 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.35 Å) | 主引用文献 | Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Mol.Cell, 2024
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8YEO
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![BU of 8yeo by Molmil](/molmil-images/mine/8yeo) | Type I-FHNH Cascade-dsDNA R-loop complex | 分子名称: | 60-nt crRNA, Cas5f, Cas6f, ... | 著者 | Li, Z. | 登録日 | 2024-02-22 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-07 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Mechanisms for HNH-mediated target DNA cleavage in type I CRISPR-Cas systems. Mol.Cell, 2024
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3IK3
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6C6P
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![BU of 6c6p by Molmil](/molmil-images/mine/6c6p) | Human squalene epoxidase (SQLE, squalene monooxygenase) structure with FAD and NB-598 | 分子名称: | (2E)-N-({3-[([3,3'-bithiophen]-5-yl)methoxy]phenyl}methyl)-N-ethyl-6,6-dimethylhept-2-en-4-yn-1-amine, 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE, FLAVIN-ADENINE DINUCLEOTIDE, ... | 著者 | Padyana, A.K, Jin, L. | 登録日 | 2018-01-19 | 公開日 | 2019-01-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure and inhibition mechanism of the catalytic domain of human squalene epoxidase. Nat Commun, 10, 2019
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6E1Y
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6UTF
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6VG0
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![BU of 6vg0 by Molmil](/molmil-images/mine/6vg0) | CRYSTAL STRUCTURE OF HUMAN CYTOSOLIC ISOCITRATE DEHYDROGENASE (IDH1) R132H MUTANT IN COMPLEX WITH NADPH and AGI-15056 | 分子名称: | Isocitrate dehydrogenase [NADP] cytoplasmic, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N~2~,N~4~-bis[(1R)-1-cyclopropylethyl]-6-[6-(trifluoromethyl)pyridin-2-yl]-1,3,5-triazine-2,4-diamine | 著者 | Padyana, A, Jin, L. | 登録日 | 2020-01-07 | 公開日 | 2020-02-05 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.66 Å) | 主引用文献 | Vorasidenib (AG-881): A First-in-Class, Brain-Penetrant Dual Inhibitor of Mutant IDH1 and 2 for Treatment of Glioma. Acs Med.Chem.Lett., 11, 2020
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6UTH
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6UTJ
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6UTI
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![BU of 6uti by Molmil](/molmil-images/mine/6uti) | |