Crystal structure of human HisRS

Summary for 4G84

DescriptorHistidine--tRNA ligase, cytoplasmic, IMIDAZOLE, CHLORIDE ION, ... (4 entities in total)
Functional Keywordssynthetase, ligase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm P12081
Total number of polymer chains2
Total molecular weight105255.58
Wei, Z.,Wu, J.,Zhou, J.J.,Yang, X.-L.,Zhang, M.,Schimmel, P. (deposition date: 2012-07-21, release date: 2012-09-26)
Primary citation
Xu, Z.,Wei, Z.,Zhou, J.J.,Ye, F.,Lo, W.S.,Wang, F.,Lau, C.F.,Wu, J.,Nangle, L.A.,Chiang, K.P.,Yang, X.L.,Zhang, M.,Schimmel, P.
Internally Deleted Human tRNA Synthetase Suggests Evolutionary Pressure for Repurposing.
Structure, 20:1470-1477, 2012
PubMed: 22958643 (PDB entries with the same primary citation)
DOI: 10.1016/j.str.2012.08.001
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24960.1%2.3%2.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4g84
no rotation
Molmil generated image of 4g84
rotated about x axis by 90°
Molmil generated image of 4g84
rotated about y axis by 90°