2XTJ

The crystal structure of PCSK9 in complex with 1D05 Fab

Summary for 2XTJ

• Entry DOI: 10.2210/pdb2xtj/pdb
• Related: 2W2M 2W2N 2W2O 2W2P 2W2Q
• Descriptor: PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9, FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05, PROPROTEIN CONVERTASE SUBTILISIN-KEXIN TYPE 9, ... (8 entities in total)
• Functional Keywords: hydrolase-antibody complex, serine protease, ldl-c, ldlr, egf-a, hypercholesterolemia, hydrolase/antibody
• Biological source: HOMO SAPIENS (HUMAN); More
• Total number of polymer chains: 6
• Total formula weight: 96433.25

Authors

Di Marco, S.,Volpari, C.,Carfi, A. (deposition date: 2010-10-10, release date: 2010-11-03, Last modification date: 2023-12-20)

• Primary citation: Ni, Y.G.,Di Marco, S.,Condra, J.H.,Peterson, L.B.,Wang, W.,Wang, F.,Pandit, S.,Hammond, H.A.,Rosa, R.,Cummings, R.T.,Wood, D.D.,Liu, X.,Bottomley, M.J.,Shen, X.,Cubbon, R.M.,Wang, S.P.,Johns, D.G.,Volpari, C.,Hamuro, L.,Chin, J.,Huang, L.,Zhao, J.Z.,Vitelli, S.,Haytko, P.,Wisniewski, D.,Mitnaul, L.J.,Sparrow, C.P.,Hubbard, B.,Carfi, A.,Sitlani, A.; A Pcsk9-Binding Antibody that Structurally Mimics the Egf(A) Domain of Ldl-Receptor Reduces Ldl Cholesterol in Vivo.; J.Lipid Res., 52:78-, 2011; PubMed: 20959675; DOI: 10.1194/JLR.M011445

Experimental method

X-RAY DIFFRACTION (2.7 Å)