2XTJ

The crystal structure of PCSK9 in complex with 1D05 Fab

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0004252	molecular_function	serine-type endopeptidase activity
A	0006508	biological_process	proteolysis
A	0008236	molecular_function	serine-type peptidase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CA A 1423

Chain	Residue
A	ALA330
A	VAL333
A	THR335
A	ASP360

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Functional Information from PROSITE/UniProt

site_id	PS00290
Number of Residues	7
Details	IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YACEVTH

Chain	Residue	Details
C	TYR191-HIS197
E	TYR212-HIS218

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	SITE: Cleavage; by autolysis => ECO:0000269|PubMed:14622975

Chain	Residue	Details
P	GLN152
A	HIS226
A	SER386

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site_id	SWS_FT_FI2
Number of Residues	1
Details	SITE: Cleavage; by furin and PCSK5 => ECO:0000269|PubMed:16912035

Chain	Residue	Details
A	ARG218

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