2XTJ
The crystal structure of PCSK9 in complex with 1D05 Fab
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | PROPROTEIN CONVERTASE SUBTILISIN/KEXIN TYPE 9 | polymer | 312 | 33083.2 | 1 | UniProt (Q8NBP7) Pfam (PF00082) In PDB | HOMO SAPIENS (HUMAN) | PCSK9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1, PROPROTEIN CONVERTASE 9, PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9 |
2 | B | FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05 | polymer | 107 | 11568.8 | 1 | HOMO SAPIENS (HUMAN) | ||
3 | C | FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05 | polymer | 106 | 11588.8 | 1 | HOMO SAPIENS (HUMAN) | ||
4 | D | FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05 | polymer | 131 | 14359.2 | 1 | HOMO SAPIENS (HUMAN) | ||
5 | E | FAB FROM A HUMAN MONOCLONAL ANTIBODY, 1D05 | polymer | 124 | 13113.6 | 1 | HOMO SAPIENS (HUMAN) | ||
6 | P | PROPROTEIN CONVERTASE SUBTILISIN-KEXIN TYPE 9 | polymer | 114 | 12679.6 | 1 | UniProt (Q8NBP7) Pfam (PF05922) In PDB | HOMO SAPIENS (HUMAN) | PCSK9, NEURAL APOPTOSIS-REGULATED CONVERTASE 1, NARC-1, PROPROTEIN CONVERTASE 9, PC9, SUBTILISIN/KEXIN-LIKE PROTEASE PC9 |
7 | A | CALCIUM ION | non-polymer | 40.1 | 1 | Chemie (CA) | |||
8 | water | water | 18.0 | 199 | Chemie (HOH) |
Sequence modifications
A: 153 - 451 (UniProt: Q8NBP7)
P: 53 - 152 (UniProt: Q8NBP7)
PDB | External Database | Details |
---|---|---|
Leu 417 | His 417 | SEE REMARK 999 |
Ala 452 | - | expression tag |
Gly 453 | - | expression tag |
Thr 454 | - | expression tag |
Ala 455 | - | expression tag |
Ala 456 | - | expression tag |
Ala 457 | - | expression tag |
Ser 458 | - | expression tag |
His 459 | - | expression tag |
His 460 | - | expression tag |
His 461 | - | expression tag |
His 462 | - | expression tag |
His 463 | - | expression tag |
His 464 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met 39 | - | expression tag |
Lys 40 | - | expression tag |
Gly 41 | - | expression tag |
Ser 42 | - | expression tag |
Lys 43 | - | expression tag |
Gly 44 | - | expression tag |
Ser 45 | - | expression tag |
Lys 46 | - | expression tag |
Gly 47 | - | expression tag |
Ser 48 | - | expression tag |
Lys 49 | - | expression tag |
Pro 50 | - | expression tag |
Met 51 | - | expression tag |
Ser 52 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 96393.2 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 40.1 | |
All* | Total formula weight | 96433.2 |