6AK4
Crystal structure of human FTO in complex with small-molecule inhibitors
Summary for 6AK4
Entry DOI | 10.2210/pdb6ak4/pdb |
Related | 6AEJ |
Descriptor | Alpha-ketoglutarate-dependent dioxygenase FTO,Alpha-ketoglutarate-dependent dioxygenase FTO, ZINC ION, (~{E})-2-cyano-~{N},~{N}-diethyl-3-[3-nitro-4,5-bis(oxidanyl)phenyl]prop-2-enamide (3 entities in total) |
Functional Keywords | oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 54492.67 |
Authors | |
Primary citation | Peng, S.,Xiao, W.,Ju, D.,Sun, B.,Hou, N.,Liu, Q.,Wang, Y.,Zhao, H.,Gao, C.,Zhang, S.,Cao, R.,Li, P.,Huang, H.,Ma, Y.,Wang, Y.,Lai, W.,Ma, Z.,Zhang, W.,Huang, S.,Wang, H.,Zhang, Z.,Zhao, L.,Cai, T.,Zhao, Y.L.,Wang, F.,Nie, Y.,Zhi, G.,Yang, Y.G.,Zhang, E.E.,Huang, N. Identification of entacapone as a chemical inhibitor of FTO mediating metabolic regulation through FOXO1. Sci Transl Med, 11:-, 2019 Cited by PubMed: 30996080DOI: 10.1126/scitranslmed.aau7116 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.8 Å) |
Structure validation
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