6AK4
Crystal structure of human FTO in complex with small-molecule inhibitors
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0006307 | biological_process | DNA alkylation repair |
| A | 0035515 | molecular_function | oxidative RNA demethylase activity |
| A | 0035516 | molecular_function | broad specificity oxidative DNA demethylase activity |
| A | 0040014 | biological_process | regulation of multicellular organism growth |
| A | 0042245 | biological_process | RNA repair |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | binding site for residue ZN A 601 |
| Chain | Residue |
| A | HIS231 |
| A | ASP233 |
| A | HIS307 |
| A | PD9602 |
| site_id | AC2 |
| Number of Residues | 15 |
| Details | binding site for residue PD9 A 602 |
| Chain | Residue |
| A | HIS231 |
| A | ASP233 |
| A | TYR295 |
| A | HIS307 |
| A | VAL309 |
| A | ARG316 |
| A | SER318 |
| A | THR320 |
| A | ARG322 |
| A | ZN601 |
| A | ARG96 |
| A | TYR106 |
| A | TYR108 |
| A | LEU109 |
| A | ASN205 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 11 |
| Details | Region: {"description":"Loop L1; predicted to block binding of double-stranded DNA or RNA","evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 6 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23547775","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28553460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"23547775","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000305"},{"source":"PubMed","id":"28553460","evidenceCode":"ECO:0000305"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXW","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXX","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4CXY","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IDZ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE0","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE5","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4IE7","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI6 |
| Number of Residues | 3 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS3","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"20376003","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25452335","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"26457839","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"3LFM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4QKN","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"4ZS2","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | Modified residue: {"description":"N6-acetyllysine","evidences":[{"source":"PubMed","id":"19608861","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
