4YTC
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6OLU
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![BU of 6olu by Molmil](/molmil-images/mine/6olu) | RIAM RA-PH core structure in the P212121 space group | 分子名称: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | 著者 | Wu, J. | 登録日 | 2019-04-17 | 公開日 | 2020-04-22 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Phosphorylation of RIAM by src promotes integrin activation by unmasking the PH domain of RIAM. Structure, 29, 2021
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6O6H
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![BU of 6o6h by Molmil](/molmil-images/mine/6o6h) | RIAM cc-RA-PH structure in the P21212 space group | 分子名称: | Amyloid beta A4 precursor protein-binding family B member 1-interacting protein | 著者 | Wu, J. | 登録日 | 2019-03-06 | 公開日 | 2020-09-02 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Phosphorylation of RIAM by Src Promotes Integrin Activation by Unmasking the PH Domain of RIAM. Structure, 2020
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4YTI
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4C4V
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3GMD
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![BU of 3gmd by Molmil](/molmil-images/mine/3gmd) | Structure-based design of 7-Azaindole-pyrrolidines as inhibitors of 11beta-Hydroxysteroid-Dehydrogenase type I | 分子名称: | 2-methyl-3-{(3S)-1-[(1-pyridin-2-ylcyclopropyl)carbonyl]pyrrolidin-3-yl}-1H-pyrrolo[2,3-b]pyridine, Corticosteroid 11-beta-dehydrogenase isozyme 1, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Valeur, E, Lepifre, F, Roche, D, Christmann-Franck, S, Hillertz, P, Musil, D. | 登録日 | 2009-03-13 | 公開日 | 2010-11-17 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (2.28 Å) | 主引用文献 | Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11 beta-hydroxysteroid dehydrogenase type I. Bioorg.Med.Chem.Lett., 22, 2012
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3FMA
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3JY9
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![BU of 3jy9 by Molmil](/molmil-images/mine/3jy9) | Janus Kinase 2 Inhibitors | 分子名称: | (3S)-3-(4-hydroxyphenyl)-1,5-dihydro-1,5,12-triazabenzo[4,5]cycloocta[1,2,3-cd]inden-4(3H)-one, SODIUM ION, Tyrosine-protein kinase JAK2 | 著者 | Zuccola, H.J, Ledeboer, M.W, Pierce, A.C. | 登録日 | 2009-09-21 | 公開日 | 2009-12-01 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Janus kinase 2 inhibitors. Synthesis and characterization of a novel polycyclic azaindole. J.Med.Chem., 52, 2009
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6YG8
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6YBB
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![BU of 6ybb by Molmil](/molmil-images/mine/6ybb) | Crystal structure of a native BcsE (217-523) - BcsR-BcsQ (R156E mutant) complex with c-di-GMP and ATP bound | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-5'-TRIPHOSPHATE, Bacterial cellulose secretion regulator BcsE, ... | 著者 | Abidi, W, Zouhir, S, Roche, S, Krasteva, P.V. | 登録日 | 2020-03-16 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Architecture and regulation of an enterobacterial cellulose secretion system. Sci Adv, 7, 2021
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6YBU
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![BU of 6ybu by Molmil](/molmil-images/mine/6ybu) | Crystal structure of a native BcsE (349-523) RQ complex with c-di-GMP and ATP bound | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), ADENOSINE-5'-TRIPHOSPHATE, Bacterial cellulose secretion regulator BcsE, ... | 著者 | Abidi, W, Zouhir, S, Roche, S, Krasteva, P.V. | 登録日 | 2020-03-17 | 公開日 | 2021-02-24 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | Architecture and regulation of an enterobacterial cellulose secretion system. Sci Adv, 7, 2021
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6QKL
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6Z5T
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6Z6I
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![BU of 6z6i by Molmil](/molmil-images/mine/6z6i) | SARS-CoV-2 Macrodomain in complex with ADP-HPD | 分子名称: | 1,2-ETHANEDIOL, 3[N-MORPHOLINO]PROPANE SULFONIC ACID, 5'-O-[(S)-{[(S)-{[(2R,3R,4S)-3,4-DIHYDROXYPYRROLIDIN-2-YL]METHOXY}(HYDROXY)PHOSPHORYL]OXY}(HYDROXY)PHOSPHORYL]ADENOSINE, ... | 著者 | Zorzini, V, Rack, J, Ahel, I. | 登録日 | 2020-05-28 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential. Open Biology, 10, 2020
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6BQK
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6BQJ
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6Z48
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![BU of 6z48 by Molmil](/molmil-images/mine/6z48) | Crystal structure of Thrombin in complex with macrocycle X1vE | 分子名称: | 5-chloranyl-N-[[(4S,15R)-2,5,13,16-tetrakis(oxidanylidene)-15-propan-2-yl-9,10-dithia-3,6,14,17-tetrazabicyclo[17.3.1]tricosa-1(22),19(23),20-trien-4-yl]methyl]thiophene-2-carboxamide, SODIUM ION, Thrombin heavy chain, ... | 著者 | Angelini, A, Habeshian, S, Heinis, C, Cendron, L. | 登録日 | 2020-05-23 | 公開日 | 2022-06-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale. Nat Commun, 13, 2022
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6Z72
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![BU of 6z72 by Molmil](/molmil-images/mine/6z72) | SARS-CoV-2 Macrodomain in complex with ADP-HPM | 分子名称: | 1,2-ETHANEDIOL, Adenosine Diphosphate (Hydroxymethyl)pyrrolidine monoalcohol, D-MALATE, ... | 著者 | Zorzini, V, Rack, J, Ahel, I. | 登録日 | 2020-05-29 | 公開日 | 2020-12-02 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential. Open Biology, 10, 2020
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8P5P
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8ONU
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7ZKR
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![BU of 7zkr by Molmil](/molmil-images/mine/7zkr) | Human GABARAP in complex with stapled peptide Pen3-ortho | 分子名称: | CHLORIDE ION, Gamma-aminobutyric acid receptor-associated protein, ORTHO-XYLENE, ... | 著者 | Ueffing, A, Brown, H, Willbold, D, Kritzer, J.A, Weiergraeber, O.H. | 登録日 | 2022-04-13 | 公開日 | 2022-08-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy. J.Am.Chem.Soc., 144, 2022
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7ZL7
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![BU of 7zl7 by Molmil](/molmil-images/mine/7zl7) | Human GABARAP in complex with stapled peptide Pen8-ortho | 分子名称: | CHLORIDE ION, Gamma-aminobutyric acid receptor-associated protein, ORTHO-XYLENE, ... | 著者 | Ueffing, A, Brown, H, Willbold, D, Kritzer, J.A, Weiergraeber, O.H. | 登録日 | 2022-04-14 | 公開日 | 2022-08-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structure-Based Design of Stapled Peptides That Bind GABARAP and Inhibit Autophagy. J.Am.Chem.Soc., 144, 2022
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6TJ0
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![BU of 6tj0 by Molmil](/molmil-images/mine/6tj0) | Crystal structure of the bacterial cellulose secretion regulator BcsE, residues 217-523, with bound c-di-GMP. | 分子名称: | 9,9'-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3',2'-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), Bacterial cellulose synthesis subunit E, GLYCEROL | 著者 | Zouhir, S, Abidi, W, Krasteva, P.V. | 登録日 | 2019-11-23 | 公開日 | 2020-07-29 | 最終更新日 | 2020-08-26 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure and Multitasking of the c-di-GMP-Sensing Cellulose Secretion Regulator BcsE. Mbio, 11, 2020
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7BK4
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![BU of 7bk4 by Molmil](/molmil-images/mine/7bk4) | Crystal structure of RXRalpha ligand binding domain in complex with a fragment of the TIF2 coactivator | 分子名称: | 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha | 著者 | le Maire, A, Bourguet, W. | 登録日 | 2021-01-15 | 公開日 | 2021-08-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J.Mol.Biol., 433, 2021
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7QUI
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![BU of 7qui by Molmil](/molmil-images/mine/7qui) | Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue | 分子名称: | (2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid, Sialic acid-binding Ig-like lectin 8 | 著者 | Lenza, M.P, Oyenarte, I, Atxabal, U, Nycholat, C, Franconetti, A, Quintana, J.I, Delgado, S, Unione, L, Paulson, J, Jimenez-Barbero, J, Ereno-Orbea, J. | 登録日 | 2022-01-18 | 公開日 | 2023-01-18 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (3.352 Å) | 主引用文献 | Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody. Jacs Au, 3, 2023
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