7QUI

Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue

Summary for 7QUI

• Entry DOI: 10.2210/pdb7qui/pdb
• Related: 7QU6 7QUH
• Descriptor: Sialic acid-binding Ig-like lectin 8, (2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid (2 entities in total)
• Functional Keywords: siglec, sialic acid, antibody, immune system
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 37164.75

Authors

Lenza, M.P.,Oyenarte, I.,Atxabal, U.,Nycholat, C.,Franconetti, A.,Quintana, J.I.,Delgado, S.,Unione, L.,Paulson, J.,Jimenez-Barbero, J.,Ereno-Orbea, J. (deposition date: 2022-01-18, release date: 2023-01-18, Last modification date: 2024-02-07)

• Primary citation: Lenza, M.P.,Atxabal, U.,Nycholat, C.,Oyenarte, I.,Franconetti, A.,Quintana, J.I.,Delgado, S.,Nunez-Franco, R.,Garnica Marroquin, C.T.,Coelho, H.,Unione, L.,Jimenez-Oses, G.,Marcelo, F.,Schubert, M.,Paulson, J.C.,Jimenez-Barbero, J.,Ereno-Orbea, J.; Structures of the Inhibitory Receptor Siglec-8 in Complex with a High-Affinity Sialoside Analogue and a Therapeutic Antibody.; Jacs Au, 3:204-215, 2023; PubMed: 36711084; DOI: 10.1021/jacsau.2c00592

Experimental method

X-RAY DIFFRACTION (3.352 Å)