7QUI

Crystal structure of the N-terminal domain of Siglec-8 in complex with sulfonamide sialoside analogue

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	B, A	Sialic acid-binding Ig-like lectin 8	polymer	153	17638.5	2	UniProt (Q9NYZ4) Pfam (PF07686) In PDB	Homo sapiens (human)	Siglec-8,Sialoadhesin family member 2,SAF-2
2	B, A	(2~{S},4~{S},5~{R},6~{R})-5-acetamido-2-[(2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{R},3~{S},4~{R},5~{R},6~{R})-5-acetamido-2-(hydroxymethyl)-4,6-bis(oxidanyl)oxan-3-yl]oxy-3,5-bis(oxidanyl)-6-(sulfooxymethyl)oxan-4-yl]oxy-6-[(1~{R},2~{R})-3-(naphthalen-2-ylsulfonylamino)-1,2-bis(oxidanyl)propyl]-4-oxidanyl-oxane-2-carboxylic acid	non-polymer		943.9	2	Chemie (F9I)

Sequence modifications

B, A: 17 - 155 (UniProt: Q9NYZ4)

PDB	External Database	Details
Ser 42	Cys 42	conflict
Gly 156	-	expression tag
Ser 157	-	expression tag
Leu 158	-	expression tag
Val 159	-	expression tag
Pro 160	-	expression tag
Arg 161	-	expression tag
Gly 162	-	expression tag
Ser 163	-	expression tag
His 164	-	expression tag
His 165	-	expression tag
His 166	-	expression tag
His 167	-	expression tag
His 168	-	expression tag
His 169	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	35276.9
Non-Polymers*	Number of molecules	2
	Total formula weight	1887.8
All*	Total formula weight	37164.8

*Water molecules are not included.