6Z48
Crystal structure of Thrombin in complex with macrocycle X1vE
Summary for 6Z48
Entry DOI | 10.2210/pdb6z48/pdb |
Descriptor | Thrombin light chain, Thrombin heavy chain, SODIUM ION, ... (5 entities in total) |
Functional Keywords | serine protease, blood clotting factor, inhibition, macrocycle, hydrolase |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 8 |
Total formula weight | 138103.82 |
Authors | Angelini, A.,Habeshian, S.,Heinis, C.,Cendron, L. (deposition date: 2020-05-23, release date: 2022-06-01, Last modification date: 2024-01-24) |
Primary citation | Habeshian, S.,Merz, M.L.,Sangouard, G.,Mothukuri, G.K.,Schuttel, M.,Bognar, Z.,Diaz-Perlas, C.,Vesin, J.,Bortoli Chapalay, J.,Turcatti, G.,Cendron, L.,Angelini, A.,Heinis, C. Synthesis and direct assay of large macrocycle diversities by combinatorial late-stage modification at picomole scale. Nat Commun, 13:3823-3823, 2022 Cited by PubMed: 35780129DOI: 10.1038/s41467-022-31428-8 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.27 Å) |
Structure validation
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