7BK4

Crystal structure of RXRalpha ligand binding domain in complex with a fragment of the TIF2 coactivator

Summary for 7BK4

Entry DOI	10.2210/pdb7bk4/pdb
Descriptor	Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID, ... (4 entities in total)
Functional Keywords	nuclear receptor, ligand binding domain, coactivator, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	4
Total formula weight	61395.13
Authors	le Maire, A.,Bourguet, W. (deposition date: 2021-01-15, release date: 2021-08-04, Last modification date: 2024-01-31)
Primary citation	Senicourt, L.,le Maire, A.,Allemand, F.,Carvalho, J.E.,Guee, L.,Germain, P.,Schubert, M.,Bernado, P.,Bourguet, W.,Sibille, N. Structural Insights into the Interaction of the Intrinsically Disordered Co-activator TIF2 with Retinoic Acid Receptor Heterodimer (RXR/RAR). J.Mol.Biol., 433:166899-166899, 2021 Cited by PubMed: 33647291 DOI: 10.1016/j.jmb.2021.166899 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation