7BK4
Crystal structure of RXRalpha ligand binding domain in complex with a fragment of the TIF2 coactivator
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Retinoic acid receptor RXR-alpha | polymer | 244 | 27269.5 | 2 | UniProt (P19793) Pfam (PF00104) | Homo sapiens (Human) | Nuclear receptor subfamily 2 group B member 1,Retinoid X receptor alpha |
| 2 | B, D (B, D) | Nuclear receptor coactivator 2 | polymer | 28 | 3064.6 | 2 | UniProt (E7EWM1) Pfam (PF08832) UniProt (by SIFTS) (Q15596) | Homo sapiens | |
| 3 | E, F (A, C) | 6-[1-(3,5,5,8,8-PENTAMETHYL-5,6,7,8-TETRAHYDRONAPHTHALEN-2-YL)CYCLOPROPYL]PYRIDINE-3-CARBOXYLIC ACID | non-polymer | 363.5 | 2 | Chemie (LG2) | |||
| 4 | G, H, I, J (A, B, C, D) | water | water | 18.0 | 69 | Chemie (HOH) |
Sequence modifications
A, C: 223 - 462 (UniProt: P19793)
| PDB | External Database | Details |
|---|---|---|
| Gly 219 | - | expression tag |
| Ser 220 | - | expression tag |
| His 221 | - | expression tag |
| Met 222 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 60668.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 727.0 | |
| All* | Total formula weight | 61395.1 |
