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7FCQ
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BU of 7fcq by Molmil
Crystallographic structure of neutralizing antibody P14-44 in complex with SARS-CoV-2 spike receptor-binding Domain (RBD)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, P14-44 antibody Fab fragment heavy chain, ...
著者Zheng, P, Jin, T.
登録日2021-07-15
公開日2022-06-15
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.89 Å)
主引用文献Ultrapotent neutralizing antibodies against SARS-CoV-2 with a high degree of mutation resistance.
J.Clin.Invest., 132, 2022
5ULA
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BU of 5ula by Molmil
Crystal Structure of the First Bromodomain of Human BRD4 in Complex With Cyclic Vinylogous Amide Inhibitor MS402
分子名称: 3-chloranyl-~{N}-(4-methoxyphenyl)-4-[(2-methyl-3-oxidanylidene-cyclopenten-1-yl)amino]benzamide, Bromodomain-containing protein 4
著者Plotnikov, A.N, Joshua, j, Zhou, M.-M.
登録日2017-01-24
公開日2017-03-22
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献BET N-terminal bromodomain inhibition selectively blocks Th17 cell differentiation and ameliorates colitis in mice.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
8F8Y
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BU of 8f8y by Molmil
PHF2 (PHD+JMJ) in Complex with VRK1 N-Terminal Peptide
分子名称: 1,2-ETHANEDIOL, Lysine-specific demethylase PHF2, SULFATE ION, ...
著者Horton, J.R, Cheng, X.
登録日2022-11-22
公開日2023-01-18
最終更新日2023-02-08
実験手法X-RAY DIFFRACTION (3.06 Å)
主引用文献A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
J.Biol.Chem., 299, 2022
8F8Z
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BU of 8f8z by Molmil
PHF2 (PHD+JMJ) in Complex with H3 Histone N-Terminal Peptide
分子名称: 1,2-ETHANEDIOL, H3 N-Terminal Peptide, Lysine-specific demethylase PHF2, ...
著者Horton, J.R, Cheng, X.
登録日2022-11-22
公開日2023-01-18
最終更新日2023-02-08
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2.
J.Biol.Chem., 299, 2022
5CR5
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BU of 5cr5 by Molmil
X-RAY CRYSTAL STRUCTURE AT 1.61A RESOLUTION OF HUMAN MITOCHONDRIAL BRANCHED CHAIN AMINOTRANSFERASE (BCATM) COMPLEXED WITH A BIPHENYL PYRROLIDINE ETHER COMPOUND AND AN INTERNAL ALDIMINE LINKED PLP COFACTOR.
分子名称: 1,2-ETHANEDIOL, 3-({(3R)-1-[(5-bromothiophen-2-yl)carbonyl]pyrrolidin-3-yl}oxy)-N-methyl-2'-[(methylsulfonyl)amino]biphenyl-4-carboxamide, Branched-chain-amino-acid aminotransferase, ...
著者Somers, D.O.
登録日2015-07-22
公開日2015-08-12
最終更新日2015-09-02
実験手法X-RAY DIFFRACTION (1.61 Å)
主引用文献Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library.
Acs Med.Chem.Lett., 6, 2015
1B6V
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BU of 1b6v by Molmil
CRYSTAL STRUCTURE OF A HYBRID BETWEEN RIBONUCLEASE A AND BOVINE SEMINAL RIBONUCLEASE
分子名称: RIBONUCLEASE
著者Vatzaki, E.H, Allen, S.C, Leonidas, D.D, Acharya, K.R.
登録日1999-01-18
公開日1999-06-15
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of a hybrid between ribonuclease A and bovine seminal ribonuclease--the basic surface, at 2.0 A resolution.
Eur.J.Biochem., 260, 1999
8G05
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BU of 8g05 by Molmil
Cryo-EM structure of an orphan GPCR-Gi protein signaling complex
分子名称: 6-(octylamino)pyrimidine-2,4(3H,5H)-dione, CHOLESTEROL, G-protein coupled receptor 84, ...
著者Zhang, X, Wang, Y.J, Li, X, Liu, G.B, Gong, W.M, Zhang, C.
登録日2023-01-31
公開日2023-11-01
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Pro-phagocytic function and structural basis of GPR84 signaling.
Nat Commun, 14, 2023
7BQP
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BU of 7bqp by Molmil
The structure of HpiI
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, 1,2-ETHANEDIOL, GLYCEROL, ...
著者Cai, Y.J, Ohashi, M, Zhou, J.H, Tang, Y.
登録日2020-03-25
公開日2020-10-14
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.33 Å)
主引用文献An enzymatic Alder-ene reaction.
Nature, 586, 2020
3OPT
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BU of 3opt by Molmil
Crystal structure of the Rph1 catalytic core with a-ketoglutarate
分子名称: 2-OXOGLUTARIC ACID, DNA damage-responsive transcriptional repressor RPH1, NICKEL (II) ION
著者Chang, Y, Wu, J, Tong, X, Zhou, J, Ding, J.
登録日2010-09-02
公開日2010-12-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
Biochem.J., 433, 2011
3OPW
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BU of 3opw by Molmil
Crystal Structure of the Rph1 catalytic core
分子名称: DNA damage-responsive transcriptional repressor RPH1
著者Chang, Y, Wu, J, Tong, X, Zhou, J, Ding, J.
登録日2010-09-02
公開日2010-12-22
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Crystal structure of the catalytic core of Saccharomyces cerevesiae histone demethylase Rph1: insights into the substrate specificity and catalytic mechanism
Biochem.J., 433, 2011
8FYA
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BU of 8fya by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-containing prespacer complex
分子名称: Cas1, Cas2-DEDDh, DNA (28-MER), ...
著者Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
登録日2023-01-25
公開日2023-05-03
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (2.91 Å)
主引用文献Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FYB
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BU of 8fyb by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex
分子名称: Cas1, Cas2-DEDDh, DNA (17-MER), ...
著者Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
登録日2023-01-25
公開日2023-05-03
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FYC
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BU of 8fyc by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex linear CRISPR repeat conformation
分子名称: Cas1, Cas2-DEDDh, DEDDh, ...
著者Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
登録日2023-01-25
公開日2023-05-03
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
8FY9
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BU of 8fy9 by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:PAM-deficient prespacer complex
分子名称: Cas1, Cas2-DEDDh, DNA (28-MER)
著者Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
登録日2023-01-25
公開日2023-05-03
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
4JN9
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BU of 4jn9 by Molmil
Crystal structure of the DepH
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DepH, ...
著者Li, J, Wang, C, Zhang, Z.M, Zhou, J.H, Cheng, E.
登録日2013-03-14
公開日2014-04-09
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis.
Sci Rep, 4, 2014
8FYD
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BU of 8fyd by Molmil
Cryo-EM structure of Cas1:Cas2-DEDDh:half-site integration complex bent CRISPR repeat conformation
分子名称: Cas1, Cas2-DEDDh, DNA (13-MER), ...
著者Skopintsev, P, Tuck, O.T, Soczek, K.M, Doudna, J.
登録日2023-01-25
公開日2023-05-03
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.9 Å)
主引用文献Genome expansion by a CRISPR trimmer-integrase.
Nature, 618, 2023
4JNA
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BU of 4jna by Molmil
Crystal structure of the DepH complex with dimethyl-FK228
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DepH, ...
著者Li, J, Wang, C, Zhang, Z.M, Zhou, J.H, Cheng, E.
登録日2013-03-14
公開日2014-03-05
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structural basis of an NADP+-independent dithiol oxidase in FK228 biosynthesis.
Sci Rep, 4, 2014
6TYB
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BU of 6tyb by Molmil
Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ...
著者Gorman, J, Kwong, P.D.
登録日2019-08-08
公開日2019-10-02
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.301 Å)
主引用文献Isolation and Structure of an Antibody that Fully Neutralizes Isolate SIVmac239 Reveals Functional Similarity of SIV and HIV Glycan Shields.
Immunity, 51, 2019
5DLK
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BU of 5dlk by Molmil
The crystal structure of CT mutant
分子名称: 1,2-ETHANEDIOL, DIMETHYL SULFOXIDE, TqaA
著者Zhang, J.R, Tang, Y, Zhou, J.H.
登録日2015-09-06
公開日2016-09-07
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural basis of nonribosomal peptide macrocyclization in fungi
Nat.Chem.Biol., 12, 2016
7D79
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BU of 7d79 by Molmil
The structure of DcsB complex with its substrate analogue
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DltD domain-containing protein, ...
著者Tang, Y, Zhou, J.H, Wang, G.Q.
登録日2020-10-03
公開日2021-01-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (2.10411429 Å)
主引用文献A Polyketide Cyclase That Forms Medium-Ring Lactones.
J.Am.Chem.Soc., 143, 2021
7M10
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BU of 7m10 by Molmil
PHF2 PHD Domain Complexed with Peptide From N-terminus of VRK1
分子名称: FORMIC ACID, Lysine-specific demethylase PHF2, Serine/threonine-protein kinase VRK1 N-terminus peptide, ...
著者Horton, J.R, Cheng, X.
登録日2021-03-11
公開日2021-05-26
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.15 Å)
主引用文献Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions.
Biochem.J., 478, 2021
5DIJ
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BU of 5dij by Molmil
The crystal structure of CT
分子名称: CHLORIDE ION, GLYCEROL, TqaA
著者Zhang, J.R, Tang, Y, Zhou, J.H.
登録日2015-09-01
公開日2016-09-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis of nonribosomal peptide macrocyclization in fungi
Nat.Chem.Biol., 12, 2016
7D78
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BU of 7d78 by Molmil
The structure of thioesterase DcsB
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, DltD domain-containing protein, ...
著者Tang, Y, Zhou, J.H, Wang, G.Q.
登録日2020-10-03
公開日2021-01-27
最終更新日2024-03-27
実験手法X-RAY DIFFRACTION (1.96543121 Å)
主引用文献A Polyketide Cyclase That Forms Medium-Ring Lactones.
J.Am.Chem.Soc., 143, 2021
5EJD
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BU of 5ejd by Molmil
The crystal structure of holo T3CT
分子名称: 4'-PHOSPHOPANTETHEINE, GLYCEROL, TqaA
著者Zhang, J.R, Tang, Y, Zhou, J.H.
登録日2015-11-01
公開日2016-10-19
最終更新日2024-04-24
実験手法X-RAY DIFFRACTION (2.49 Å)
主引用文献Structural basis of nonribosomal peptide macrocyclization in fungi
Nat.Chem.Biol., 12, 2016
5EGF
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BU of 5egf by Molmil
The crystal structure of SeMet-CT
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, 1,2-ETHANEDIOL, TqaA
著者Zhang, J.R, Tang, Y, Zhou, J.H.
登録日2015-10-27
公開日2016-10-19
最終更新日2020-02-19
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Structural basis of nonribosomal peptide macrocyclization in fungi
Nat.Chem.Biol., 12, 2016

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