7CXM
| Architecture of a SARS-CoV-2 mini replication and transcription complex | 分子名称: | Helicase, Non-structural protein 7, Non-structural protein 8, ... | 著者 | Yan, L, Zhang, Y, Ge, J, Zheng, L, Gao, Y, Wang, T, Jia, Z, Wang, H, Huang, Y, Li, M, Wang, Q, Rao, Z, Lou, Z. | 登録日 | 2020-09-02 | 公開日 | 2020-11-04 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Architecture of a SARS-CoV-2 mini replication and transcription complex. Nat Commun, 11, 2020
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7VOD
| Crystal structure of 5-HT2AR in complex with cariprazine | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[4-[2-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]ethyl]cyclohexyl]-1,1-dimethyl-urea, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | 登録日 | 2021-10-13 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat.Neurosci., 25, 2022
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7VOE
| Crystal structure of 5-HT2AR in complex with aripiprazole | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, 7-[4-[4-[2,3-bis(chloranyl)phenyl]piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one, ... | 著者 | Chen, Z, Fan, L, Wang, H, Yu, J, Lu, D, Qi, J, Nie, F, Luo, Z, Liu, Z, Cheng, J, Wang, S. | 登録日 | 2021-10-13 | 公開日 | 2021-12-22 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Structure-based design of a novel third-generation antipsychotic drug lead with potential antidepressant properties. Nat.Neurosci., 25, 2022
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3VPS
| Structure of a novel NAD dependent-NDP-hexosamine 5,6-dehydratase, TunA, involved in tunicamycin biosynthesis | 分子名称: | NAD-dependent epimerase/dehydratase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE | 著者 | Wyszynski, F.J, Lee, S.S, Yabe, T, Wang, H, Gomez-Escribano, J.P, Bibb, M.J, Lee, S.J, Davies, G.J, Davis, B.G. | 登録日 | 2012-03-12 | 公開日 | 2012-04-18 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Biosynthesis of nucleoside antibiotic tunicamycin proceeds via unique exo-glycal intermediates To be published
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5GW4
| Structure of Yeast NPP-TRiC | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Zang, Y, Jin, M, Wang, H, Cong, Y. | 登録日 | 2016-09-08 | 公開日 | 2016-10-26 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM. Nat. Struct. Mol. Biol., 23, 2016
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5GW5
| Structure of TRiC-AMP-PNP | 分子名称: | T-complex protein 1 subunit alpha, T-complex protein 1 subunit beta, T-complex protein 1 subunit delta, ... | 著者 | Zang, Y, Jin, M, Wang, H, Cong, Y. | 登録日 | 2016-09-08 | 公開日 | 2016-10-26 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Staggered ATP binding mechanism of eukaryotic chaperonin TRiC (CCT) revealed through high-resolution cryo-EM. Nat. Struct. Mol. Biol., 23, 2016
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4RHP
| Crystal structure of human COQ9 in complex with a phospholipid, Northeast Structural Genomics Consortium Target HR5043 | 分子名称: | DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, Ubiquinone biosynthesis protein COQ9, mitochondrial | 著者 | Forouhar, F, Lew, S, Seetharaman, J, Wang, H, Lee, D, Kogan, S, Maglaqui, M, Xiao, R, Everett, J.K, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG), Mitochondrial Protein Partnership (MPP) | 登録日 | 2014-10-02 | 公開日 | 2014-10-22 | 最終更新日 | 2019-08-14 | 実験手法 | X-RAY DIFFRACTION (2.393 Å) | 主引用文献 | Mitochondrial COQ9 is a lipid-binding protein that associates with COQ7 to enable coenzyme Q biosynthesis. Proc.Natl.Acad.Sci.USA, 111, 2014
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8FU6
| GCGR-Gs complex in the presence of RAMP2 | 分子名称: | Glucagon derivative ZP3780, Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Krishna Kumar, K, O'Brien, E.S, Wang, H, Montabana, E, Kobilka, B.K. | 登録日 | 2023-01-16 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Negative allosteric modulation of the glucagon receptor by RAMP2. Cell, 186, 2023
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8FNI
| Cryo-EM structure of RNase-treated RESC-B in trypanosomal RNA editing | 分子名称: | RNA-editing substrate-binding complex protein 10 (RESC10), RNA-editing substrate-binding complex protein 11 (RESC11), RNA-editing substrate-binding complex protein 13 (RESC13), ... | 著者 | Liu, S, Wang, H, Li, X, Zhang, F, Lee, J.K.J, Li, Z, Yu, C, Zhao, X, Hu, J.J, Suematsu, T, Alvarez-Cabrera, A.L, Liu, Q, Zhang, L, Huang, L, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H. | 登録日 | 2022-12-27 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science, 381, 2023
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8FNF
| Cryo-EM structure of RNase-untreated RESC-C in trypanosomal RNA editing | 分子名称: | Mitochondrial RNA binding complex 1 subunit, Mitochondrial RNA binding protein, Phytanoyl-CoA dioxygenase family protein, ... | 著者 | Liu, S, Wang, H, Li, X, Zhang, F, Lee, J.K.J, Li, Z, Yu, C, Zhao, X, Hu, J.J, Suematsu, T, Alvarez-Cabrera, A.L, Liu, Q, Zhang, L, Huang, L, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H. | 登録日 | 2022-12-27 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science, 381, 2023
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8FN4
| Cryo-EM structure of RNase-treated RESC-A in trypanosomal RNA editing | 分子名称: | RNA-editing substrate-binding complex protein 1 (RESC1), RNA-editing substrate-binding complex protein 2 (RESC2), RNA-editing substrate-binding complex protein 3 (RESC3), ... | 著者 | Liu, S, Wang, H, Li, X, Zhang, F, Lee, J.K.J, Li, Z, Yu, C, Zhao, X, Hu, J.J, Suematsu, T, Alvarez-Cabrera, A.L, Liu, Q, Zhang, L, Huang, L, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H. | 登録日 | 2022-12-26 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science, 381, 2023
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8FNC
| Cryo-EM structure of RNase-treated RESC-C in trypanosomal RNA editing | 分子名称: | Mitochondrial RNA binding complex 1 subunit, Mitochondrial RNA binding protein, Phytanoyl-CoA dioxygenase family protein, ... | 著者 | Liu, S, Wang, H, Li, X, Zhang, F, Lee, J.K.J, Li, Z, Yu, C, Zhao, X, Hu, J.J, Suematsu, T, Alvarez-Cabrera, A.L, Liu, Q, Zhang, L, Huang, L, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H. | 登録日 | 2022-12-27 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science, 381, 2023
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8FNK
| Cryo-EM structure of RNase-untreated RESC-B in trypanosomal RNA editing | 分子名称: | RNA-editing substrate-binding complex protein 10 (RESC10), RNA-editing substrate-binding complex protein 11 (RESC11), RNA-editing substrate-binding complex protein 13 (RESC13), ... | 著者 | Liu, S, Wang, H, Li, X, Zhang, F, Lee, J.K.J, Li, Z, Yu, C, Zhao, X, Hu, J.J, Suematsu, T, Alvarez-Cabrera, A.L, Liu, Q, Zhang, L, Huang, L, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H. | 登録日 | 2022-12-27 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science, 381, 2023
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8FN6
| Cryo-EM structure of RNase-untreated RESC-A in trypanosomal RNA editing | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, RNA-editing substrate-binding complex protein 1 (RESC1), RNA-editing substrate-binding complex protein 2 (RESC2), ... | 著者 | Liu, S, Wang, H, Li, X, Zhang, F, Lee, J.K.J, Li, Z, Yu, C, Zhao, X, Hu, J.J, Suematsu, T, Alvarez-Cabrera, A.L, Liu, Q, Zhang, L, Huang, L, Aphasizheva, I, Aphasizhev, R, Zhou, Z.H. | 登録日 | 2022-12-27 | 公開日 | 2023-07-19 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural basis of gRNA stabilization and mRNA recognition in trypanosomal RNA editing. Science, 381, 2023
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8GHR
| Structure of human ENPP1 in complex with variable heavy domain VH27.2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE MONOPHOSPHATE, ... | 著者 | Carozza, J.A, Wang, H, Solomon, P.E, Wells, J.A, Li, L. | 登録日 | 2023-03-10 | 公開日 | 2023-08-02 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Discovery of VH domains that allosterically inhibit ENPP1. Nat.Chem.Biol., 20, 2024
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8HG1
| The structure of MPXV polymerase holoenzyme in replicating state | 分子名称: | DNA (25-MER), DNA (38-MER), DNA polymerase, ... | 著者 | Peng, Q, Xie, Y.F, Kuai, L, Wang, H, Qi, J.X, Gao, F, Shi, Y. | 登録日 | 2022-11-13 | 公開日 | 2022-12-21 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure of monkeypox virus DNA polymerase holoenzyme. Science, 379, 2023
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1A8O
| HIV CAPSID C-TERMINAL DOMAIN | 分子名称: | HIV CAPSID | 著者 | Gamble, T.R, Yoo, S, Vajdos, F.F, Von Schwedler, U.K, Worthylake, D.K, Wang, H, Mccutcheon, J.P, Sundquist, W.I, Hill, C.P. | 登録日 | 1998-03-27 | 公開日 | 1998-10-14 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science, 278, 1997
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1A43
| STRUCTURE OF THE HIV-1 CAPSID PROTEIN DIMERIZATION DOMAIN AT 2.6A RESOLUTION | 分子名称: | HIV-1 CAPSID | 著者 | Worthylake, D.K, Wang, H, Yoo, S, Sundquist, W.I, Hill, C.P. | 登録日 | 1998-02-10 | 公開日 | 1999-02-09 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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1BAJ
| HIV-1 CAPSID PROTEIN C-TERMINAL FRAGMENT PLUS GAG P2 DOMAIN | 分子名称: | GAG POLYPROTEIN | 著者 | Worthylake, D.K, Wang, H, Yoo, S, Sundquist, W.I, Hill, C.P. | 登録日 | 1998-04-17 | 公開日 | 1998-10-14 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Structures of the HIV-1 capsid protein dimerization domain at 2.6 A resolution. Acta Crystallogr.,Sect.D, 55, 1999
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1AUM
| HIV CAPSID C-TERMINAL DOMAIN (CAC146) | 分子名称: | HIV CAPSID | 著者 | Hill, C.P, Gamble, T.R, Yoo, S, Vajdos, F.F, Von Schwedler, U.K, Worthylake, D.K, Wang, H, Mccutcheon, J.P, Sundquist, W.I. | 登録日 | 1997-08-29 | 公開日 | 1998-01-14 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structure of the carboxyl-terminal dimerization domain of the HIV-1 capsid protein. Science, 278, 1997
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1BC9
| CYTOHESIN-1/B2-1 SEC7 DOMAIN, NMR, MINIMIZED AVERAGE STRUCTURE | 分子名称: | CYTOHESIN-1 | 著者 | Betz, S.F, Schnuchel, A, Wang, H, Olejniczak, E.T, Meadows, R.P, Fesik, S.W. | 登録日 | 1998-05-06 | 公開日 | 1999-05-11 | 最終更新日 | 2024-05-22 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution structure of the cytohesin-1 (B2-1) Sec7 domain and its interaction with the GTPase ADP ribosylation factor 1. Proc.Natl.Acad.Sci.USA, 95, 1998
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2LEK
| Solution NMR structure of a Thiamine Biosynthesis (ThiS) Protein RPA3574 from Rhodopseudomonas palustris refined with NH RDCs. Northeast Structural Genomics Consortium target RpR325 | 分子名称: | Putative thiamin biosynthesis ThiS | 著者 | Ramelot, T.A, Cort, J.R, Lee, H, Wang, H, Ciccosanti, C, Jiang, M, Nair, R, Rost, B, Acton, T.B, Xiao, R, Swapna, G, Everett, J.K, Prestegard, J.H, Montelione, G.T, Kennedy, M.A, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2011-06-16 | 公開日 | 2011-06-29 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Solution NMR structure of a Thiamine Biosynthesis (ThiS) Protein RPA3574 from Rhodopseudomonas palustris. Northeast Structural Genomics Consortium target RpR325 To be Published
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7TN7
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7TN4
| Diphosphoinositol polyphosphate phosphohydrolase 1 (DIPP1/NUDT3) in complex with 3-diphosphoinositol 1,2,4,5-tetrakisphosphate (3-PP-IP4), Mg and Fluoride ion | 分子名称: | (1R,2S,3R,4R,5S,6S)-4-hydroxy-2,3,5,6-tetrakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, CHLORIDE ION, Diphosphoinositol polyphosphate phosphohydrolase 1, ... | 著者 | Zong, G, Wang, H, Shears, S.B. | 登録日 | 2022-01-20 | 公開日 | 2022-06-15 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and catalytic analyses of the InsP 6 kinase activities of higher plant ITPKs. Faseb J., 36, 2022
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7TN5
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