7FEJ
| Complex of FMDV A/AF/72 and bovine neutralizing scFv antibody R55 | 分子名称: | A/AF/72 VP1, A/AF/72 VP2, A/AF/72 VP3, ... | 著者 | He, Y, Li, K, Lou, Z. | 登録日 | 2021-07-20 | 公開日 | 2021-09-29 | 最終更新日 | 2022-02-16 | 実験手法 | ELECTRON MICROSCOPY (3.91 Å) | 主引用文献 | Structures of Foot-and-Mouth Disease Virus with Bovine Neutralizing Antibodies Reveal the Determinant of Intraserotype Cross-Neutralization. J.Virol., 95, 2021
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8E17
| BRD4-D1 in complex with BET inhibitor | 分子名称: | (4P,6M)-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-4-[5-(methanesulfonyl)-2-methoxyphenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | 登録日 | 2022-08-09 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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8DYR
| BRD4-D1 in complex with BET inhibitor | 分子名称: | (4P,6P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-6-[1-(2-fluoroethyl)-1H-1,2,3-triazol-4-yl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | 登録日 | 2022-08-04 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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8E3W
| BRD4-D1 in complex with BET inhibitor | 分子名称: | (4P)-4-[2-(cyclopropylmethoxy)-5-(methanesulfonyl)phenyl]-2-methylisoquinolin-1(2H)-one, 1,2-ETHANEDIOL, Bromodomain-containing protein 4 | 著者 | Gorman, M.A, Fitzgerald, C.G.D, White, J.M, Parker, M.W. | 登録日 | 2022-08-17 | 公開日 | 2023-03-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.47 Å) | 主引用文献 | Bromodomain and extraterminal protein-targeted probe enables tumour visualisation in vivo using positron emission tomography. Chem.Commun.(Camb.), 59, 2023
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8KG6
| Yeast replisome in state I | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, Chromosome segregation in meiosis protein 3, ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.07 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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8KG8
| Yeast replisome in state II | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.23 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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8EJM
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8ERR
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8ERQ
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8KG9
| Yeast replisome in state III | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45, DNA (61-mer), ... | 著者 | Dang, S, Zhai, Y, Feng, J, Yu, D, Xu, Z. | 登録日 | 2023-08-17 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.52 Å) | 主引用文献 | Synergism between CMG helicase and leading strand DNA polymerase at replication fork. Nat Commun, 14, 2023
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7CJM
| SARS CoV-2 PLpro in complex with GRL0617 | 分子名称: | 5-amino-2-methyl-N-[(1R)-1-naphthalen-1-ylethyl]benzamide, Non-structural protein 3, ZINC ION | 著者 | Fu, Z, Huang, H. | 登録日 | 2020-07-11 | 公開日 | 2020-09-02 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The complex structure of GRL0617 and SARS-CoV-2 PLpro reveals a hot spot for antiviral drug discovery. Nat Commun, 12, 2021
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5YI8
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4GYE
| MDR 769 HIV-1 Protease in Complex with Reduced P1F | 分子名称: | P1F peptide, Protease | 著者 | Dewdney, T.G, Wang, Y, Brunzelle, J, Reiter, S.J, Kovari, I.A, Kovari, L.C. | 登録日 | 2012-09-05 | 公開日 | 2013-10-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease. Bioorg.Med.Chem., 21, 2013
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5YI7
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4GZF
| Multi-drug resistant HIV-1 protease 769 variant with reduced LrF peptide | 分子名称: | LrF peptide, Protease | 著者 | Dewdney, T.G, Wang, Y, Kovari, I.A, Brunzelle, J.S, Reiter, S.J, Kovari, L.C. | 登録日 | 2012-09-06 | 公開日 | 2013-10-30 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Ligand modifications to reduce the relative resistance of multi-drug resistant HIV-1 protease. Bioorg.Med.Chem., 21, 2013
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8HDK
| Structure of the Rat GluN1-GluN2C NMDA receptor in complex with glycine and glutamate (minor class in symmetry) | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Glutamate receptor ionotropic, ... | 著者 | Zhang, M, Zhang, J, Guo, F, Li, Y, Zhu, S. | 登録日 | 2022-11-04 | 公開日 | 2023-03-29 | 最終更新日 | 2023-05-31 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Distinct structure and gating mechanism in diverse NMDA receptors with GluN2C and GluN2D subunits. Nat.Struct.Mol.Biol., 30, 2023
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8HLW
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8HLY
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4B6H
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7C1D
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6OQ5
| Structure of the full-length Clostridium difficile toxin B in complex with 3 VHHs | 分子名称: | 5D, 7F, E3, ... | 著者 | Chen, P, Lam, K, Jin, R. | 登録日 | 2019-04-25 | 公開日 | 2019-07-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.87 Å) | 主引用文献 | Structure of the full-length Clostridium difficile toxin B. Nat.Struct.Mol.Biol., 26, 2019
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8IWS
| hSPCA1 in the CaE2P state | 分子名称: | BERYLLIUM TRIFLUORIDE ION, CALCIUM ION, Calcium-transporting ATPase type 2C member 1, ... | 著者 | Liu, Z.M, Wu, M.Q, Wu, C. | 登録日 | 2023-03-31 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWP
| hSPCA1 in the CaE1 state | 分子名称: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1 | 著者 | Liu, Z.M, Wu, M.Q, Wu, C. | 登録日 | 2023-03-30 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWT
| hSPCA1 in the early E2P state | 分子名称: | BERYLLIUM TRIFLUORIDE ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION | 著者 | Liu, Z.M, Wu, M.Q, Wu, C. | 登録日 | 2023-03-31 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.25 Å) | 主引用文献 | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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8IWR
| hSPCA1 in the CaE1-ATP state | 分子名称: | CALCIUM ION, Calcium-transporting ATPase type 2C member 1, MAGNESIUM ION, ... | 著者 | Liu, Z.M, Wu, M.Q, Wu, C. | 登録日 | 2023-03-31 | 公開日 | 2023-12-27 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | Structure and transport mechanism of the human calcium pump SPCA1. Cell Res., 33, 2023
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