7WLU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7wlu by Molmil](/molmil-images/mine/7wlu) | The Flattened Structure of mPIEZO1 in Lipid Bilayer | 分子名称: | (9R,11S)-9-({[(1S)-1-HYDROXYHEXADECYL]OXY}METHYL)-2,2-DIMETHYL-5,7,10-TRIOXA-2LAMBDA~5~-AZA-6LAMBDA~5~-PHOSPHAOCTACOSANE-6,6,11-TRIOL, Piezo-type mechanosensitive ion channel component 1 | 著者 | Yang, X, Lin, C, Chen, X, Li, S, Li, X, Xiao, B. | 登録日 | 2022-01-13 | 公開日 | 2022-04-13 | 最終更新日 | 2024-06-26 | 実験手法 | ELECTRON MICROSCOPY (6.81 Å) | 主引用文献 | Structure deformation and curvature sensing of PIEZO1 in lipid membranes. Nature, 604, 2022
|
|
8JQK
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jqk by Molmil](/molmil-images/mine/8jqk) | Crystal structure of a carbonyl reductase SSCR mutant from Sporobolomyces Salmonicolor | 分子名称: | Aldehyde reductase 2 | 著者 | Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M. | 登録日 | 2023-06-14 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer Acs Catalysis, 13, 2023
|
|
8JQJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jqj by Molmil](/molmil-images/mine/8jqj) | Crystal structure of carbonyl reductase SSCR mutant 1 from Sporobolomyces Salmonicolor | 分子名称: | Aldehyde reductase 2 | 著者 | Zhang, H.L, Li, Q, Liu, W.D, Chen, X, Wu, Q.Q, Zhu, D.M. | 登録日 | 2023-06-14 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Engineering a Carbonyl Reductase to Simultaneously Increase Activity Toward Bulky Ketone and Isopropanol for Dynamic Kinetic Asymmetric Reduction via Enzymatic Hydrogen Transfer Acs Catalysis, 13, 2023
|
|
5ZHY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5zhy by Molmil](/molmil-images/mine/5zhy) | Structural characterization of the HCoV-229E fusion core | 分子名称: | Spike glycoprotein | 著者 | Zhang, W, Zheng, Q, Yan, M, Chen, X, Yang, H, Zhou, W, Rao, Z. | 登録日 | 2018-03-13 | 公開日 | 2018-06-06 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.441 Å) | 主引用文献 | Structural characterization of the HCoV-229E fusion core. Biochem. Biophys. Res. Commun., 497, 2018
|
|
7W6V
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7w6v by Molmil](/molmil-images/mine/7w6v) | Crystal structure of a dicobalt-substituted small laccase at 2.47 angstrom | 分子名称: | COBALT (II) ION, Putative copper oxidase | 著者 | Yang, X, Wu, F, Wu, W, Chen, X, Fan, S, Yu, P, Mao, L. | 登録日 | 2021-12-02 | 公開日 | 2022-11-09 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | A versatile artificial metalloenzyme scaffold enabling direct bioelectrocatalysis in solution. Sci Adv, 8, 2022
|
|
7VKM
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vkm by Molmil](/molmil-images/mine/7vkm) | Crystal structure of TrkA (G595R) kinase domain | 分子名称: | Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
|
|
7VKO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vko by Molmil](/molmil-images/mine/7vko) | Crystal structure of TrkA kinase with repotrectinib | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
|
|
7VKN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7vkn by Molmil](/molmil-images/mine/7vkn) | Crystal structure of TrkA (G595R) kinase with repotrectinib | 分子名称: | Repotrectinib, SULFATE ION, Tyrosine-protein kinase receptor | 著者 | Murray, B.W, Rogers, E, Zhai, D, Deng, W, Chen, X, Sprengeler, P.A, Zhang, X, Graber, A, Reich, S.H, Stopatschinskaja, S, Solomon, B, Besse, B, Drilon, A. | 登録日 | 2021-09-30 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Molecular Characteristics of Repotrectinib That Enable Potent Inhibition of TRK Fusion Proteins and Resistant Mutations. Mol.Cancer Ther., 20, 2021
|
|
6DQD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dqd by Molmil](/molmil-images/mine/6dqd) | |
6DQE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dqe by Molmil](/molmil-images/mine/6dqe) | |
8HHG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hhg by Molmil](/molmil-images/mine/8hhg) | |
8HHH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hhh by Molmil](/molmil-images/mine/8hhh) | |
8HHF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8hhf by Molmil](/molmil-images/mine/8hhf) | |
8JDN
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdn by Molmil](/molmil-images/mine/8jdn) | Crystal structure of H405A mLDHD in complex with D-2-hydroxyvaleric acid | 分子名称: | (2R)-2-oxidanylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jds by Molmil](/molmil-images/mine/8jds) | Crystal structure of mLDHD in complex with Pyruvate | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, PYRUVIC ACID, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.636 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdb by Molmil](/molmil-images/mine/8jdb) | Crystal structure of H405A mLDHD in complex with D-2-hydroxyoctanoic acid | 分子名称: | (2R)-2-oxidanyloctanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-13 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdc by Molmil](/molmil-images/mine/8jdc) | Crystal structure of mLDHD in apo form | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-13 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.696 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDQ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdq by Molmil](/molmil-images/mine/8jdq) | Crystal structure of H405A mLDHD in complex with D-2-hydroxyisocaproic acid | 分子名称: | (2R)-2-hydroxy-4-methylpentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDT
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdt by Molmil](/molmil-images/mine/8jdt) | Crystal structure of mLDHD in complex with 2-ketobutanoic acid | 分子名称: | 2-KETOBUTYRIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDV
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdv by Molmil](/molmil-images/mine/8jdv) | Crystal structure of mLDHD in complex with 2-ketohexanoic acid | 分子名称: | 2-Ketohexanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdg by Molmil](/molmil-images/mine/8jdg) | Crystal structure of H405A mLDHD in complex with D-2-hydroxybutanoic acid | 分子名称: | (2R)-2-oxidanylbutanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-14 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.31 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDR
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdr by Molmil](/molmil-images/mine/8jdr) | Crystal structure of H405A mLDHD in complex with D-2-hydroxy-3-methyl-valeric acid | 分子名称: | (2R,3S)-3-methyl-2-oxidanyl-pentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDU
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdu by Molmil](/molmil-images/mine/8jdu) | Crystal structure of mLDHD in complex with 2-ketovaleric acid | 分子名称: | 2-oxopentanoic acid, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDY
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdy by Molmil](/molmil-images/mine/8jdy) | Crystal structure of mLDHD in complex with 2-ketoisocaproic acid | 分子名称: | 2-OXO-4-METHYLPENTANOIC ACID, FLAVIN-ADENINE DINUCLEOTIDE, MANGANESE (II) ION, ... | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-15 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|
8JDD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8jdd by Molmil](/molmil-images/mine/8jdd) | Crystal structure of H405A mLDHD in apo form | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Probable D-lactate dehydrogenase, mitochondrial | 著者 | Jin, S, Chen, X, Yang, J, Ding, J. | 登録日 | 2023-05-13 | 公開日 | 2023-10-18 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Lactate dehydrogenase D is a general dehydrogenase for D-2-hydroxyacids and is associated with D-lactic acidosis. Nat Commun, 14, 2023
|
|