4GX5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gx5 by Molmil](/molmil-images/mine/4gx5) | GsuK Channel | 分子名称: | CALCIUM ION, POTASSIUM ION, TrkA domain protein, ... | 著者 | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | 登録日 | 2012-09-03 | 公開日 | 2012-12-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. elife, 1, 2012
|
|
4GX0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gx0 by Molmil](/molmil-images/mine/4gx0) | Crystal structure of the GsuK L97D mutant | 分子名称: | CALCIUM ION, PHOSPHATE ION, POTASSIUM ION, ... | 著者 | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | 登録日 | 2012-09-03 | 公開日 | 2012-12-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.601 Å) | 主引用文献 | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. elife, 1, 2012
|
|
4GX2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gx2 by Molmil](/molmil-images/mine/4gx2) | GsuK channel bound to NAD | 分子名称: | CALCIUM ION, NICOTINAMIDE-ADENINE-DINUCLEOTIDE, PHOSPHATE ION, ... | 著者 | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | 登録日 | 2012-09-03 | 公開日 | 2012-12-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. elife, 1, 2012
|
|
4GX1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gx1 by Molmil](/molmil-images/mine/4gx1) | Crystal structure of the GsuK bound to ADP | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, CALCIUM ION, PHOSPHATE ION, ... | 著者 | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | 登録日 | 2012-09-03 | 公開日 | 2012-12-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. elife, 1, 2012
|
|
4GVL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4gvl by Molmil](/molmil-images/mine/4gvl) | Crystal Structure of the GsuK RCK domain | 分子名称: | ADENOSINE MONOPHOSPHATE, CALCIUM ION, TrkA domain protein, ... | 著者 | Kong, C, Zeng, W, Ye, S, Chen, L, Sauer, D.B, Lam, Y, Derebe, M.G, Jiang, Y. | 登録日 | 2012-08-30 | 公開日 | 2012-12-26 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Distinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channel. elife, 1, 2012
|
|
3OUS
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ous by Molmil](/molmil-images/mine/3ous) | MthK channel pore T59A mutant | 分子名称: | Calcium-gated potassium channel mthK, POTASSIUM ION | 著者 | Derebe, M.G, Sauer, D.B, Zeng, W, Alam, A, Shi, N, Jiang, Y. | 登録日 | 2010-09-15 | 公開日 | 2011-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
6NQ2
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nq2 by Molmil](/molmil-images/mine/6nq2) | Cryo-EM structure of human TPC2 channel in the ligand-bound closed state | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | 登録日 | 2019-01-18 | 公開日 | 2019-03-27 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
|
|
6NQ1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nq1 by Molmil](/molmil-images/mine/6nq1) | Cryo-EM structure of human TPC2 channel in the apo state | 分子名称: | Two pore calcium channel protein 2 | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | 登録日 | 2019-01-18 | 公開日 | 2019-03-27 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
|
|
6NQ0
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6nq0 by Molmil](/molmil-images/mine/6nq0) | Cryo-EM structure of human TPC2 channel in the ligand-bound open state | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | 登録日 | 2019-01-18 | 公開日 | 2019-03-27 | 最終更新日 | 2019-11-20 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel. Elife, 8, 2019
|
|
3R65
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3r65 by Molmil](/molmil-images/mine/3r65) | MthK channel pore E92Q mutant | 分子名称: | Calcium-gated potassium channel mthK, POTASSIUM ION | 著者 | Shi, N, Zeng, W, Ye, S, Li, Y, Jiang, Y. | 登録日 | 2011-03-21 | 公開日 | 2012-02-01 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Crucial points within the pore as determinants of K+ channel conductance and gating J.Mol.Biol., 411, 2011
|
|
3OUF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3ouf by Molmil](/molmil-images/mine/3ouf) | Structure of a K+ selective NaK mutant | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, POTASSIUM ION, Potassium channel protein | 著者 | Derebe, M.G, Sauer, D.B, Zeng, W, Alam, A, Shi, N, Jiang, Y. | 登録日 | 2010-09-14 | 公開日 | 2011-01-12 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Tuning the ion selectivity of tetrameric cation channels by changing the number of ion binding sites. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3T2M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3t2m by Molmil](/molmil-images/mine/3t2m) | Crystal Structure of NaK Channel N68D Mutant | 分子名称: | POTASSIUM ION, Potassium channel protein | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | 登録日 | 2011-07-22 | 公開日 | 2011-10-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
3T1C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3t1c by Molmil](/molmil-images/mine/3t1c) | Crystal Structure of NaK Channel D66Y Mutant | 分子名称: | POTASSIUM ION, Potassium channel protein | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | 登録日 | 2011-07-21 | 公開日 | 2011-10-05 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation. Proc.Natl.Acad.Sci.USA, 108, 2011
|
|
5TUA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 5tua by Molmil](/molmil-images/mine/5tua) | structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1 | 分子名称: | BARIUM ION, CALCIUM ION, SODIUM ION, ... | 著者 | Guo, J, Zeng, W, Jiang, Y. | 登録日 | 2016-11-05 | 公開日 | 2017-01-18 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Tuning the ion selectivity of two-pore channels. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
|
|
6JLC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6jlc by Molmil](/molmil-images/mine/6jlc) | |
7RH9
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rh9 by Molmil](/molmil-images/mine/7rh9) | Cryo-EM structure of human rod CNGA1/B1 channel in apo state | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-16 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.61 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
6E68
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6e68 by Molmil](/molmil-images/mine/6e68) | NAMPT co-crystal with inhibitor compound 2 | 分子名称: | (2E)-N-{4-[1-(3-aminobenzene-1-carbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | 著者 | Waight, A.B, Neumann, C.S. | 登録日 | 2018-07-24 | 公開日 | 2018-08-08 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | NAMPT co-crystal with inhibitor compound 2 to be published
|
|
6DXO
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dxo by Molmil](/molmil-images/mine/6dxo) | 1.8 A structure of RsbN-BldN complex. | 分子名称: | BldN, RNA polymerase ECF-subfamily sigma factor | 著者 | Schumacher, M.A. | 登録日 | 2018-06-29 | 公開日 | 2018-07-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | The crystal structure of the RsbN-sigma BldN complex from Streptomyces venezuelae defines a new structural class of anti-sigma factor. Nucleic Acids Res., 46, 2018
|
|
8FY5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fy5 by Molmil](/molmil-images/mine/8fy5) | Human TMEM175-LAMP1 full-length complex | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | 登録日 | 2023-01-25 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
|
|
8FYF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8fyf by Molmil](/molmil-images/mine/8fyf) | Human TMEM175-LAMP1 transmembrane domain only complex | 分子名称: | Endosomal/lysosomal potassium channel TMEM175, Lysosome-associated membrane glycoprotein 1 | 著者 | Zhang, J.Y, Zeng, W.Z, Han, Y, Jiang, Y.X. | 登録日 | 2023-01-26 | 公開日 | 2023-06-28 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel. Mol.Cell, 83, 2023
|
|
7RHH
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rhh by Molmil](/molmil-images/mine/7rhh) | Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openI state | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rhg by Molmil](/molmil-images/mine/7rhg) | Cryo-EM structure of human rod CNGA1/B1 channel in cAMP-bound state | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHJ
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rhj by Molmil](/molmil-images/mine/7rhj) | Cryo-EM structure of human rod CNGA1/B1 channel in L-cis-Diltiazem-blocked open state | 分子名称: | (2R,3R)-5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate, CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, ... | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHL
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rhl by Molmil](/molmil-images/mine/7rhl) | Cryo-EM structure of human rod Apo CNGA1/B1 channel with CLZ coiled coil | 分子名称: | Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.03 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|
7RHI
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7rhi by Molmil](/molmil-images/mine/7rhi) | Cryo-EM structure of human rod CNGA1/B1 channel in cGMP-bound openII state | 分子名称: | CYCLIC GUANOSINE MONOPHOSPHATE, Cyclic nucleotide-gated cation channel beta-1, cGMP-gated cation channel alpha-1 | 著者 | Xue, J, Han, Y, Jiang, Y. | 登録日 | 2021-07-17 | 公開日 | 2021-11-03 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (3.31 Å) | 主引用文献 | Structural mechanisms of assembly, permeation, gating, and pharmacology of native human rod CNG channel. Neuron, 110, 2022
|
|