4QE9
 
 | | Open MthK pore structure soaked in 10 mM Ba2+/100 mM K+ | | 分子名称: | Calcium-gated potassium channel MthK, POTASSIUM ION | | 著者 | Guo, R, Zeng, W, Cui, H, Chen, L, Ye, S. | | 登録日 | 2014-05-15 | | 公開日 | 2014-07-09 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | Ionic interactions of Ba2+ blockades in the MthK K+ channel
J.Gen.Physiol., 144, 2014
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3T2M
 | | Crystal Structure of NaK Channel N68D Mutant | | 分子名称: | POTASSIUM ION, Potassium channel protein | | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | 登録日 | 2011-07-22 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.953 Å) | | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3T1C
 | | Crystal Structure of NaK Channel D66Y Mutant | | 分子名称: | POTASSIUM ION, Potassium channel protein | | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | 登録日 | 2011-07-21 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.802 Å) | | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3R65
 | | MthK channel pore E92Q mutant | | 分子名称: | Calcium-gated potassium channel mthK, POTASSIUM ION | | 著者 | Shi, N, Zeng, W, Ye, S, Li, Y, Jiang, Y. | | 登録日 | 2011-03-21 | | 公開日 | 2012-02-01 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crucial points within the pore as determinants of K+ channel conductance and gating
J.Mol.Biol., 411, 2011
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3T4D
 | | Crystal Structure of NaK2K Channel Y55F Mutant | | 分子名称: | POTASSIUM ION, Potassium channel protein | | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | 登録日 | 2011-07-25 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3T4Z
 | | Crystal Structure of NaK2K Channel Y55W Mutant | | 分子名称: | POTASSIUM ION, Potassium channel protein | | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | 登録日 | 2011-07-26 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TCU
 | | Crystal Structure of NaK2K Channel D68E Mutant | | 分子名称: | POTASSIUM ION, Potassium channel protein | | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | 登録日 | 2011-08-09 | | 公開日 | 2011-10-05 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3TET
 | | Crystal Structure of NaK2K Channel Y66F Mutant | | 分子名称: | POTASSIUM ION, Potassium channel protein | | 著者 | Sauer, D.B, Zeng, W, Raghunathan, S, Jiang, Y. | | 登録日 | 2011-08-15 | | 公開日 | 2011-10-19 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Protein interactions central to stabilizing the K+ channel selectivity filter in a four-sited configuration for selective K+ permeation.
Proc.Natl.Acad.Sci.USA, 108, 2011
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6NQ0
 | | Cryo-EM structure of human TPC2 channel in the ligand-bound open state | | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2019-01-18 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
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6NQ2
 | | Cryo-EM structure of human TPC2 channel in the ligand-bound closed state | | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, Two pore calcium channel protein 2 | | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2019-01-18 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
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6NQ1
 | | Cryo-EM structure of human TPC2 channel in the apo state | | 分子名称: | Two pore calcium channel protein 2 | | 著者 | She, J, Zeng, W, Guo, J, Chen, Q, Bai, X, Jiang, Y. | | 登録日 | 2019-01-18 | | 公開日 | 2019-03-27 | | 最終更新日 | 2019-11-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural mechanisms of phospholipid activation of the human TPC2 channel.
Elife, 8, 2019
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5HAW
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5HBU
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5TUA
 | | structure of a Na+-selective mutant of two-pore channel from Arabidopsis thaliana AtTPC1 | | 分子名称: | BARIUM ION, CALCIUM ION, SODIUM ION, ... | | 著者 | Guo, J, Zeng, W, Jiang, Y. | | 登録日 | 2016-11-05 | | 公開日 | 2017-01-18 | | 最終更新日 | 2023-10-04 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Tuning the ion selectivity of two-pore channels.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6JLC
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6XPE
 | | Cryo-EM structure of human ZnT8 WT, in the presence of zinc, determined in outward-facing conformation | | 分子名称: | ZINC ION, Zinc transporter 8 | | 著者 | Bai, X.C, Xue, J, Jiang, Y.X. | | 登録日 | 2020-07-08 | | 公開日 | 2020-08-05 | | 最終更新日 | 2024-03-06 | | 実験手法 | ELECTRON MICROSCOPY (4.1 Å) | | 主引用文献 | Cryo-EM structures of human ZnT8 in both outward- and inward-facing conformations.
Elife, 9, 2020
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6XPD
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6E68
 | | NAMPT co-crystal with inhibitor compound 2 | | 分子名称: | (2E)-N-{4-[1-(3-aminobenzene-1-carbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, Nicotinamide phosphoribosyltransferase, PHOSPHATE ION | | 著者 | Waight, A.B, Neumann, C.S. | | 登録日 | 2018-07-24 | | 公開日 | 2018-08-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | NAMPT co-crystal with inhibitor compound 2
to be published
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7SQ6
 | | Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1, ... | | 著者 | Gan, N, Han, Y, Jiang, Y. | | 登録日 | 2021-11-04 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (2.32 Å) | | 主引用文献 | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SQ9
 | | Cryo-EM structure of mouse temsirolimus/PI(3,5)P2-bound TRPML1 channel at 2.11 Angstrom resolution | | 分子名称: | (1R,2R,4S)-4-{(2R)-2-[(3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,30S,34aS)-9,27-dihydroxy-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-1,5,11,28,29-pentaoxo-1,4,5,6,9,10,11,12,13,14,21,22,23,24,25,26,27,28,29,31,32,33,34,34a-tetracosahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontin-3-yl]propyl}-2-methoxycyclohexyl 3-hydroxy-2-(hydroxymethyl)-2-methylpropanoate, (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Gan, N, Han, Y, Jiang, Y. | | 登録日 | 2021-11-04 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (2.11 Å) | | 主引用文献 | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SQ8
 | | Cryo-EM structure of mouse apo TRPML1 channel at 2.598 Angstrom resolution | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, SODIUM ION | | 著者 | Gan, N, Han, Y, Jiang, Y. | | 登録日 | 2021-11-04 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (2.598 Å) | | 主引用文献 | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7SQ7
 | | Cryo-EM structure of mouse PI(3,5)P2-bound TRPML1 channel at 2.41 Angstrom resolution | | 分子名称: | (2R)-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,4,6-trihydroxy-3,5-bis(phosphonooxy)cyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Mucolipin-1, ... | | 著者 | Gan, N, Han, Y, Jiang, Y. | | 登録日 | 2021-11-04 | | 公開日 | 2022-02-02 | | 最終更新日 | 2022-02-23 | | 実験手法 | ELECTRON MICROSCOPY (2.41 Å) | | 主引用文献 | Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin.
Proc.Natl.Acad.Sci.USA, 119, 2022
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6U9X
 | | Structure of T. brucei MERS1-RNA complex | | 分子名称: | Mitochondrial edited mRNA stability factor 1, RNA (5'-R(*GP*AP*GP*AP*GP*GP*GP*GP*GP*UP*U)-3') | | 著者 | Schumacher, M.A. | | 登録日 | 2019-09-09 | | 公開日 | 2019-11-06 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structures of MERS1, the 5' processing enzyme of mitochondrial mRNAs inTrypanosoma brucei.
Rna, 26, 2020
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6GMS
 | | Solution NMR structure of the major type IV pilin PpdD from enterohemorrhagic Escherichia coli (EHEC) | | 分子名称: | Prepilin peptidase-dependent protein D | | 著者 | Amorim, G.C, Bardiaux, B, Luna-Rico, A, Zeng, W, Guilvout, I, Egelman, E, Nilges, M, Francetic, O, Izadi-Pruneyre, N. | | 登録日 | 2018-05-28 | | 公開日 | 2019-05-15 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure and Assembly of the Enterohemorrhagic Escherichia coli Type 4 Pilus.
Structure, 27, 2019
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7V42
 | | Crystal structure of Class I P450 monooxygenase (P450tol) from Rhodococcus coprophilus TC-2 in complex with benzyl-alcohol. | | 分子名称: | PHOSPHATE ION, PROTOPORPHYRIN IX CONTAINING FE, p450tol monooxygenase, ... | | 著者 | Zhang, L.L, Huang, J.W, Liu, W.D, Chen, C.C, Guo, R.T. | | 登録日 | 2021-08-12 | | 公開日 | 2022-06-22 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | | 主引用文献 | Molecular Basis for a Toluene Monooxygenase to Govern Substrate Selectivity
Acs Catalysis, 12, 2022
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