6E68

NAMPT co-crystal with inhibitor compound 2

Summary for 6E68

• Entry DOI: 10.2210/pdb6e68/pdb
• Descriptor: Nicotinamide phosphoribosyltransferase, PHOSPHATE ION, (2E)-N-{4-[1-(3-aminobenzene-1-carbonyl)piperidin-4-yl]butyl}-3-(pyridin-3-yl)prop-2-enamide, ... (4 entities in total)
• Functional Keywords: nicotinamide phosphoribosyltransferase, cytotoxic, antibody-drug conjugates, anti-tumor, cytosolic protein, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 109986.45

Authors

Waight, A.B.,Neumann, C.S. (deposition date: 2018-07-24, release date: 2018-08-08, Last modification date: 2023-10-11)

• Primary citation: Neumann, C.S.,Olivas, K.C.,Anderson, M.E.,Cochran, J.H.,Jin, S.,Li, F.,Loftus, L.V.,Meyer, D.W.,Neale, J.,Nix, J.C.,Pittman, P.G.,Simmons, J.K.,Ulrich, M.L.,Waight, A.B.,Wong, A.,Zaval, M.C.,Zeng, W.,Lyon, R.P.,Senter, P.D.; NAMPT co-crystal with inhibitor compound 2; to be published,

Experimental method

X-RAY DIFFRACTION (1.5 Å)