6JB3
 
 | | Structure of SUR1 subunit bound with repaglinide | | 分子名称: | ATP-binding cassette sub-family C member 8 isoform X2, Digitonin, Repaglinide | | 著者 | Chen, L, Ding, D, Wang, M, Wu, J.-X, Kang, Y. | | 登録日 | 2019-01-25 | | 公開日 | 2019-05-22 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.53 Å) | | 主引用文献 | The Structural Basis for the Binding of Repaglinide to the Pancreatic KATPChannel.
Cell Rep, 27, 2019
|
|
6JT2
 | | Structure of human soluble guanylate cyclase in the NO activated state | | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | | 登録日 | 2019-04-08 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
|
|
6JT0
 | | Structure of human soluble guanylate cyclase in the unliganded state | | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | | 登録日 | 2019-04-08 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
|
|
6JT1
 | | Structure of human soluble guanylate cyclase in the heme oxidised state | | 分子名称: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | | 登録日 | 2019-04-08 | | 公開日 | 2019-08-28 | | 最終更新日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural insights into the mechanism of human soluble guanylate cyclase.
Nature, 574, 2019
|
|
7Y1J
 | | Structure of SUR2A in complex with Mg-ATP and repaglinide in the inward-facing conformation. | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | | 著者 | Chen, L, Ding, D, Hou, T. | | 登録日 | 2022-06-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
|
|
7Y1L
 | | Structure of SUR2B in complex with Mg-ATP and repaglinide in the inward-facing conformation | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, MAGNESIUM ION, ... | | 著者 | Chen, L, Ding, D, Hou, T. | | 登録日 | 2022-06-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.73 Å) | | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
|
|
7Y1K
 | | Structure of SUR2A in complex with Mg-ATP, Mg-ADP and repaglinide in the inward-facing conformation | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ATP-binding cassette sub-family C member 9, ... | | 著者 | Chen, L, Ding, D, Hou, T. | | 登録日 | 2022-06-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
|
|
7Y1M
 | | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the inward-facing conformation | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | | 著者 | Chen, L, Ding, D, Hou, T. | | 登録日 | 2022-06-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.57 Å) | | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
|
|
7Y1N
 | | Structure of SUR2B in complex with Mg-ATP, Mg-ADP, and repaglinide in the partially occluded state | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Isoform SUR2B of ATP-binding cassette sub-family C member 9, ... | | 著者 | Chen, L, Ding, D, Hou, T. | | 登録日 | 2022-06-08 | | 公開日 | 2023-06-14 | | 最終更新日 | 2023-10-11 | | 実験手法 | ELECTRON MICROSCOPY (3.61 Å) | | 主引用文献 | The inhibition mechanism of the SUR2A-containing K ATP channel by a regulatory helix.
Nat Commun, 14, 2023
|
|
5ZBG
 | |
5YX9
 | |
7VLT
 | | Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim | | 分子名称: | (3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, L, Ding, D. | | 登録日 | 2021-10-05 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
|
|
7VLR
 | | Structure of SUR2B in complex with Mg-ATP/ADP | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ... | | 著者 | Chen, L, Ding, D. | | 登録日 | 2021-10-05 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
|
|
7VLU
 | | Structure of SUR2A in complex with Mg-ATP/ADP and P1075 | | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, L, Ding, D. | | 登録日 | 2021-10-05 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
|
|
7VLS
 | | Structure of SUR2B in complex with MgATP/ADP and P1075 | | 分子名称: | 1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, L, Ding, D. | | 登録日 | 2021-10-05 | | 公開日 | 2022-05-18 | | 最終更新日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | | 主引用文献 | Structural identification of vasodilator binding sites on the SUR2 subunit.
Nat Commun, 13, 2022
|
|
7W4P
 | | The structure of KATP H175K mutant in closed state | | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, L, Wang, M. | | 登録日 | 2021-11-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
|
|
7W4O
 | | The structure of KATP H175K mutant in pre-open state | | 分子名称: | 6-chloranyl-~{N}-(1-methylcyclopropyl)-1,1-bis(oxidanylidene)-4~{H}-thieno[3,2-e][1,2,4]thiadiazin-3-amine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Chen, L, Wang, M. | | 登録日 | 2021-11-28 | | 公開日 | 2022-06-01 | | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | | 主引用文献 | Structural insights into the mechanism of pancreatic K ATP channel regulation by nucleotides.
Nat Commun, 13, 2022
|
|
7WIT
 | | Structure of SUR1 in complex with mitiglinide | | 分子名称: | (2S)-4-[(3aR,7aS)-1,3,3a,4,5,6,7,7a-octahydroisoindol-2-yl]-4-oxidanylidene-2-(phenylmethyl)butanoic acid, ADENOSINE-5'-TRIPHOSPHATE, ATP-sensitive inward rectifier potassium channel 11,ATP-binding cassette sub-family C member 8 isoform X1 | | 著者 | Chen, L, Wang, M.M. | | 登録日 | 2022-01-04 | | 公開日 | 2022-11-16 | | 最終更新日 | 2024-06-26 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Structural Insights Into the High Selectivity of the Anti-Diabetic Drug Mitiglinide
Front Pharmacol, 13, 2022
|
|
7D4P
 | | Structure of human TRPC5 in complex with clemizole | | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1-[(4-chlorophenyl)methyl]-2-(pyrrolidin-1-ylmethyl)benzimidazole, ... | | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | | 登録日 | 2020-09-24 | | 公開日 | 2021-03-31 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Elife, 10, 2021
|
|
7D4Q
 | | Structure of human TRPC5 in complex with HC-070 | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 8-(3-chloranylphenoxy)-7-[(4-chlorophenyl)methyl]-3-methyl-1-(3-oxidanylpropyl)purine-2,6-dione, CALCIUM ION, ... | | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | | 登録日 | 2020-09-24 | | 公開日 | 2021-03-31 | | 最終更新日 | 2021-10-13 | | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Elife, 10, 2021
|
|
7E4T
 | | Human TRPC5 apo state structure at 3 angstrom | | 分子名称: | (2S)-2-(hexadecanoyloxy)-3-hydroxypropyl (9Z)-octadec-9-enoate, (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CALCIUM ION, ... | | 著者 | Chen, L, Song, K, Wei, M, Guo, W. | | 登録日 | 2021-02-15 | | 公開日 | 2021-03-31 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | Structural basis for human TRPC5 channel inhibition by two distinct inhibitors.
Elife, 10, 2021
|
|
7DXD
 | |
7DXF
 | |
7DXC
 | | Structure of TRPC3 at 3.06 angstrom in low calcium state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, CHOLESTEROL HEMISUCCINATE, Short transient receptor potential channel 3, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
7DXG
 | | Structure of SAR7334-bound TRPC6 at 2.9 angstrom | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 4-[[(1R,2R)-2-[(3R)-3-azanylpiperidin-1-yl]-2,3-dihydro-1H-inden-1-yl]oxy]-3-chloranyl-benzenecarbonitrile, CALCIUM ION, ... | | 著者 | Chen, L, Guo, W. | | 登録日 | 2021-01-18 | | 公開日 | 2022-02-02 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Structural mechanism of human TRPC3 and TRPC6 channel regulation by their intracellular calcium-binding sites.
Neuron, 110, 2022
|
|
