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7AZD
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BU of 7azd by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 20 bound
分子名称: Beta sliding clamp, DI(HYDROXYETHYL)ETHER, PENTAETHYLENE GLYCOL, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.19 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZE
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BU of 7aze by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 18 bound
分子名称: Beta sliding clamp, GLYCEROL, MALONATE ION, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.82 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZC
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BU of 7azc by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 22 bound
分子名称: Beta sliding clamp, GLYCEROL, Peptide 22
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZF
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BU of 7azf by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 8 bound
分子名称: Beta sliding clamp, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZK
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BU of 7azk by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 35 bound
分子名称: Beta sliding clamp, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZ5
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BU of 7az5 by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 47 bound
分子名称: Beta sliding clamp, DI(HYDROXYETHYL)ETHER, Peptide 47, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZL
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BU of 7azl by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 38 bound
分子名称: Beta sliding clamp, DI(HYDROXYETHYL)ETHER, GLYCEROL, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-07-10
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZ7
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BU of 7az7 by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 37 bound
分子名称: Beta sliding clamp, FORMIC ACID, PENTAETHYLENE GLYCOL, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
7AZ6
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BU of 7az6 by Molmil
DNA polymerase sliding clamp from Escherichia coli with peptide 36 bound
分子名称: ACETATE ION, Beta sliding clamp, CHLORIDE ION, ...
著者Monsarrat, C, Compain, G, Andre, C, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Brillet, K, Landolfo, M, Silva da Veiga, C, Wagner, J, Guichard, G, Burnouf, D.Y.
登録日2020-11-16
公開日2021-12-01
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Iterative Structure-Based Optimization of Short Peptides Targeting the Bacterial Sliding Clamp.
J.Med.Chem., 64, 2021
1SKO
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BU of 1sko by Molmil
MP1-p14 Complex
分子名称: Late endosomal/lysosomal Mp1 interacting protein, Mitogen-activated protein kinase kinase 1 interacting protein 1
著者Lunin, V.V, Munger, C, Wagner, J, Ye, Z, Cygler, M, Sacher, M.
登録日2004-03-05
公開日2004-06-01
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献The structure of the MAP kinase scaffold MP1 bound to its partner p14: a complex with a critical role in endosomal MAP kinase signaling
J.Biol.Chem., 279, 2004
1BHX
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BU of 1bhx by Molmil
X-RAY STRUCTURE OF THE COMPLEX OF HUMAN ALPHA THROMBIN WITH THE INHIBITOR SDZ 229-357
分子名称: 5-OXO-6-PHENYLMETHANESULFONYLAMINO-HEXAHYDRO-THIAZOLO[3,2-A]PYRIDINE-3-CARBOXYLIC ACID (3-GUANIDINO-PROPYL)-AMIDE, ALPHA THROMBIN
著者Kallen, J.
登録日1998-06-10
公開日1998-11-04
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Rational design, synthesis, and X-ray structure of selective noncovalent thrombin inhibitors.
J.Med.Chem., 41, 1998
3IW4
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BU of 3iw4 by Molmil
Crystal structure of PKC alpha in complex with NVP-AEB071
分子名称: 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]-1H-pyrrole-2,5-dione, Protein kinase C alpha type
著者Stark, W, Rummel, G, Strauss, A, Cowan-Jacob, S.W.
登録日2009-09-02
公開日2009-11-03
最終更新日2021-11-10
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of 3-(1H-indol-3-yl)-4-[2-(4-methylpiperazin-1-yl)quinazolin-4-yl]pyrrole-2,5-dione (AEB071), a potent and selective inhibitor of protein kinase C isotypes
J.Med.Chem., 52, 2009
8TZX
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BU of 8tzx by Molmil
Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1
分子名称: (3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione, 1,2-ETHANEDIOL, DNA damage-binding protein 1, ...
著者Clifton, M.C, Ma, X, Ornelas, E.
登録日2023-08-28
公開日2024-07-10
最終更新日2024-07-17
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献A molecular glue degrader of the WIZ transcription factor for fetal hemoglobin induction.
Science, 385, 2024
8GCC
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BU of 8gcc by Molmil
T. cruzi topoisomerase II alpha bound to dsDNA and the covalent inhibitor CT1
分子名称: 2-{3-[(Z)-iminomethyl]-1H-1,2,4-triazol-1-yl}-1-{(3M)-3-[2-(trifluoromethyl)phenyl]-6H-pyrrolo[3,4-b]pyridin-6-yl}ethan-1-one, DNA (28-MER), DNA topoisomerase 2
著者Schenk, A, Deniston, C, Noeske, J.
登録日2023-03-01
公開日2023-07-12
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Cyanotriazoles are selective topoisomerase II poisons that rapidly cure trypanosome infections.
Science, 380, 2023
8PAT
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BU of 8pat by Molmil
Structure of the E.coli DNA polymerase sliding clamp with a covalently bound peptide 3.
分子名称: ACE-GLN-ALC-GLX-LEU-PHE, Beta sliding clamp
著者Compain, G, Monsarrat, C, Blagojevic, J, Brillet, K, Dumas, P, Hammann, P, Kuhn, L, Martiel, I, Engilberge, S, Olieric, V, Wolff, P, Burnouf, D, Guichard, G.
登録日2023-06-08
公開日2024-03-13
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Peptide-Based Covalent Inhibitors Bearing Mild Electrophiles to Target a Conserved His Residue of the Bacterial Sliding Clamp.
Jacs Au, 4, 2024
6Q7A
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BU of 6q7a by Molmil
RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 4 AT 2.2A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称: 1-[2,6-bis(chloranyl)phenyl]-2-(furan-2-yl)-5-methyl-4-(phenylmethyl)imidazole, Nuclear receptor ROR-gamma
著者Kallen, J.
登録日2018-12-13
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors.
J.Med.Chem., 62, 2019
6Q6O
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BU of 6q6o by Molmil
RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 2 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称: CHOLIC ACID, Nuclear receptor ROR-gamma, propan-2-yl (2~{S})-2-[[2,6-bis(chloranyl)phenyl]-(furan-2-ylcarbonyl)amino]propanoate
著者Kallen, J.
登録日2018-12-11
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors.
J.Med.Chem., 62, 2019
6Q7H
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BU of 6q7h by Molmil
RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 9 AT 2.3A: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称: 1-[2,4-bis(chloranyl)-3-[2-(5-chloranylfuran-2-yl)-5-methyl-4-(trifluoromethyl)imidazol-1-yl]phenyl]azetidine-3-carboxylic acid, Nuclear receptor ROR-gamma
著者Kallen, J.
登録日2018-12-13
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors.
J.Med.Chem., 62, 2019
6Q6M
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BU of 6q6m by Molmil
RORCVAR2 (RORGT, 264-499) IN COMPLEX WITH COMPOUND 1: Identification of N-aryl imidazoles as potent and selective RORgt inhibitors
分子名称: Nuclear receptor ROR-gamma, ethyl (2~{S})-2-[(2-chloranyl-6-methyl-phenyl)-thiophen-2-ylcarbonyl-amino]propanoate
著者Kallen, J.
登録日2018-12-11
公開日2019-11-27
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Structure-Based and Property-Driven Optimization ofN-Aryl Imidazoles toward Potent and Selective Oral ROR gamma t Inhibitors.
J.Med.Chem., 62, 2019
1XHN
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BU of 1xhn by Molmil
The crystal structure of Cellular Repressor of E1A-stimulated Genes (CREG)
分子名称: Cellular Repressor of E1A-stimulated Genes
著者Sacher, M, Lunin, V.V, Cygler, M.
登録日2004-09-20
公開日2005-11-15
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The crystal structure of CREG, a secreted glycoprotein involved in cellular growth and differentiation
Proc.Natl.Acad.Sci.Usa, 102, 2005
3B8O
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BU of 3b8o by Molmil
Structure of WzzE- Bacterial Polysaccharide Co-polymerase
分子名称: Lipopolysaccharide biosynthesis protein wzzE
著者Tocilj, A, Matte, A, Cygler, M.
登録日2007-11-01
公開日2008-01-22
最終更新日2017-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Bacterial polysaccharide co-polymerases share a common framework for control of polymer length
Nat.Struct.Mol.Biol., 15, 2008
3B8N
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BU of 3b8n by Molmil
Structure of FepE- Bacterial Polysaccharide Co-polymerase
分子名称: Ferric enterobactin (Enterochelin) transport
著者Tocilj, A, Matte, A, Cygler, M.
登録日2007-11-01
公開日2008-01-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Bacterial polysaccharide co-polymerases share a common framework for control of polymer length
Nat.Struct.Mol.Biol., 15, 2008
3B8M
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BU of 3b8m by Molmil
Structure of FepE- Bacterial Polysaccharide Co-polymerase
分子名称: Ferric enterobactin (Enterochelin) transport
著者Tocilj, A, Matte, A, Cygler, M.
登録日2007-11-01
公開日2008-01-22
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Bacterial polysaccharide co-polymerases share a common framework for control of polymer length
Nat.Struct.Mol.Biol., 15, 2008
3B8P
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BU of 3b8p by Molmil
Fragment of WzzB, Polysaccharide Co-polymerase from Salmonella Typhimurium
分子名称: Chain length determinant protein
著者Tocilj, A, Matte, A, Cygler, M.
登録日2007-11-01
公開日2008-01-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Bacterial polysaccharide co-polymerases share a common framework for control of polymer length
Nat.Struct.Mol.Biol., 15, 2008
4TR7
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BU of 4tr7 by Molmil
Crystal structure of DNA polymerase sliding clamp from Mycobaterium tuberculosis
分子名称: DNA polymerase III subunit beta
著者Olieric, V, Burnouf, D, Ennifar, E, Wolff, P.
登録日2014-06-14
公開日2014-09-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Differential Modes of Peptide Binding onto Replicative Sliding Clamps from Various Bacterial Origins.
J.Med.Chem., 57, 2014

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件を2024-08-28に公開中

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