8TZX
Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1
Summary for 8TZX
Entry DOI | 10.2210/pdb8tzx/pdb |
Descriptor | Protein cereblon, DNA damage-binding protein 1, Protein Wiz, ... (8 entities in total) |
Functional Keywords | complex, glue, ligase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 6 |
Total formula weight | 280743.67 |
Authors | |
Primary citation | Ting, P.,Reyes, A.,Fodor, B.D.,Wu, F.,Belew, M.S.,Mao, X.,Wang, J.,Chitnis, S.,Niu, W.,Hachey, A.,Cobb, J.S.,Savage, N.A.,Burke, A.,Paulk, J.,Dovala, D.,Lin, J.,Clifton, M.C.,Ornelas, E.,Ma, X.,Ware, N.F.,Sanchez, C.C.,Trarszka, J.,Terranova, R.,Knehr, J.,Altorfer, M.,Barnes, S.W.,Beckwith, R.E.J.,Solomon, J.M.,Dales, N.A.,Patterson, A.W.,Wagner, J.,Bouwmeester, T.,Dranoff, G.,Stevenson, S.C.,Bradner, J.E. Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1 Science, 2024 Cited by DOI: 10.1126/science.adk6129PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.15 Å) |
Structure validation
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