8TZX

Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, D (A, D)	Protein cereblon	polymer	373	42971.6	2	UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226)	Homo sapiens (human)
2	B, E (B, E)	DNA damage-binding protein 1	polymer	836	93347.1	2	UniProt (Q16531) Pfam (PF10433) Pfam (PF03178)	Homo sapiens (human)	DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe
3	C, F (C, F)	Protein Wiz	polymer	30	3299.7	2	UniProt (O95785)	Homo sapiens (human)	Widely-interspaced zinc finger-containing protein,Zinc finger protein 803
4	G, L, M, Q (A, C, D, F)	ZINC ION	non-polymer		65.4	4	Chemie (ZN)
5	H, N (A, D)	(3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione	non-polymer		399.5	2	Chemie (U3I)
6	I, K, O, P (A, B, D, E)	SULFATE ION	non-polymer		96.1	4	Chemie (SO4)
7	J (B)	1,2-ETHANEDIOL	non-polymer		62.1	1	Chemie (EDO)
8	R, S, T, U, V (A, B, D, E, F)	water	water		18.0	12	Chemie (HOH)

Sequence modifications

B, E: 1 - 699 (UniProt: Q16531)
B, E: 706 - 1140 (UniProt: Q16531)

PDB	External Database	Details
Gly 700	-	linker
Asn 701	-	linker
Gly 702	-	linker
Asn 703	-	linker
Ser 704	-	linker
Gly 705	-	linker

C, F: 867 - 895 (UniProt: O95785)

PDB	External Database	Details
Ser 866	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	279236.7
Non-Polymers*	Number of molecules	11
	Total formula weight	1506.9
All*	Total formula weight	280743.7

*Water molecules are not included.