8TZX
Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, D | Protein cereblon | polymer | 373 | 42971.6 | 2 | UniProt (Q96SW2) In PDB | Homo sapiens (human) | |
2 | B, E | DNA damage-binding protein 1 | polymer | 836 | 93347.1 | 2 | UniProt (Q16531) In PDB | Homo sapiens (human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
3 | C, F | Protein Wiz | polymer | 30 | 3299.7 | 2 | UniProt (O95785) In PDB | Homo sapiens (human) | Widely-interspaced zinc finger-containing protein,Zinc finger protein 803 |
4 | A, C, D, F | ZINC ION | non-polymer | 65.4 | 4 | Chemie (ZN) | |||
5 | A, D | (3S)-3-(5-{(1R)-1-[(2R)-1-ethylpiperidin-2-yl]ethoxy}-1-oxo-1,3-dihydro-2H-isoindol-2-yl)piperidine-2,6-dione | non-polymer | 399.5 | 2 | Chemie (U3I) | |||
6 | A, B, D, E | SULFATE ION | non-polymer | 96.1 | 4 | Chemie (SO4) | |||
7 | B | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
8 | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
B, E: 1 - 699 (UniProt: Q16531)
B, E: 706 - 1140 (UniProt: Q16531)
C, F: 867 - 895 (UniProt: O95785)
B, E: 706 - 1140 (UniProt: Q16531)
PDB | External Database | Details |
---|---|---|
Gly 700 | - | linker |
Asn 701 | - | linker |
Gly 702 | - | linker |
Asn 703 | - | linker |
Ser 704 | - | linker |
Gly 705 | - | linker |
PDB | External Database | Details |
---|---|---|
Ser 866 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 6 |
Total formula weight | 279236.7 | |
Non-Polymers* | Number of molecules | 11 |
Total formula weight | 1506.9 | |
All* | Total formula weight | 280743.7 |