8TZX
Ternary complex structure of Cereblon-DDB1 bound to WIZ(ZF7) and the molecular glue dWIZ-1
Functional Information from PROSITE/UniProt
| site_id | PS00028 |
| Number of Residues | 21 |
| Details | ZINC_FINGER_C2H2_1 Zinc finger C2H2 type domain signature. Cev..CgacFetrkglssHars..H |
| Chain | Residue | Details |
| C | CYS872-HIS892 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 44 |
| Details | ZN_FING: C2H2-type 7 => ECO:0000255|PROSITE-ProRule:PRU00042 |
| Chain | Residue | Details |
| C | THR870-HIS892 | |
| D | HIS378 | |
| D | TRP380 | |
| D | TRP386 | |
| D | CYS391 | |
| D | CYS394 | |
| F | THR870-HIS892 | |
| A | HIS378 | |
| A | TRP380 | |
| A | TRP386 | |
| A | CYS391 | |
| A | CYS394 | |
| D | CYS323 | |
| D | CYS326 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| C | LYS883 | |
| E | LYS1067 | |
| F | LYS883 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0000250|UniProtKB:Q9ESW0 |
| Chain | Residue | Details |
| B | THR1125 | |
| E | THR1125 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) => ECO:0007744|PubMed:28112733 |
| Chain | Residue | Details |
| B | LYS1121 | |
| E | LYS1121 |
