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4F1R
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BU of 4f1r by Molmil
Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginos
分子名称: Catabolite repression control protein
著者Zhang, H, Wei, Y, Gao, Z.Q, Dong, Y.H.
登録日2012-05-07
公開日2013-02-06
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.201 Å)
主引用文献Structure analysis of the global metabolic regulator Crc from Pseudomonas aeruginosa.
Iubmb Life, 65, 2013
4EFE
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BU of 4efe by Molmil
crystal structure of DNA ligase
分子名称: BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, SULFATE ION, ...
著者Wei, Y, Wang, T, Charifson, P, Xu, W.
登録日2012-03-29
公開日2013-04-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献crystal structure of DNA ligase
To be Published
4EFB
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BU of 4efb by Molmil
Crystal structure of DNA ligase
分子名称: 4-amino-2-(cyclopentyloxy)-6-{[(1R,2S)-2-hydroxycyclopentyl]oxy}pyrimidine-5-carboxamide, BETA-NICOTINAMIDE RIBOSE MONOPHOSPHATE, DNA ligase, ...
著者Wei, Y, Wang, T, Charifson, P, Xu, W.
登録日2012-03-29
公開日2013-04-03
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal structure of DNA ligase
To be Published
6P6B
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BU of 6p6b by Molmil
CS-Rosetta Model of PEA-15 Death Effector Domain
分子名称: Astrocytic phosphoprotein PEA-15
著者Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S.
登録日2019-06-03
公開日2019-07-24
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions.
Int J Mol Sci, 20, 2019
6P6C
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BU of 6p6c by Molmil
CS-Rosetta Model of PEA-15 Death Effector Domain in the Complex with ERK2
分子名称: Astrocytic phosphoprotein PEA-15
著者Wei, Y, Crespo Flores, S, Cabezas, A, Hassan, S.
登録日2019-06-03
公開日2019-07-24
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献PEA-15 C-Terminal Tail Allosterically Modulates Death-Effector Domain Conformation and Facilitates Protein-Protein Interactions.
Int J Mol Sci, 20, 2019
6VTI
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BU of 6vti by Molmil
Solution NMR structure of the N-terminal domain of the Serine/threonine-protein phosphatase 1 regulatory subunit 10, PPP1R10
分子名称: Serine/threonine-protein phosphatase 1 regulatory subunit 10
著者Lemak, A, Wei, Y, Duan, S, Houliston, S, Penn, L.Z, Arrowsmith, C.H.
登録日2020-02-12
公開日2020-02-26
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Nucleic Acids Res., 50, 2022
7LQT
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BU of 7lqt by Molmil
Solution NMR structure of the PNUTS amino-terminal Domain fused to Myc Homology Box 0
分子名称: Serine/threonine-protein phosphatase 1 regulatory subunit 10,Myc proto-oncogene protein fusion
著者Lemak, A, Wei, Y, Duan, S, Houliston, S, Penn, L.Z, Arrowsmith, C.H.
登録日2021-02-15
公開日2021-03-03
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献The MYC oncoprotein directly interacts with its chromatin cofactor PNUTS to recruit PP1 phosphatase.
Nucleic Acids Res., 50, 2022
2OIN
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BU of 2oin by Molmil
crystal structure of HCV NS3-4A R155K mutant
分子名称: NS4A peptide, Polyprotein, ZINC ION
著者Wei, Y.
登録日2007-01-11
公開日2007-06-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Phenotypic and structural analyses of hepatitis C virus NS3 protease Arg155 variants: sensitivity to telaprevir (VX-950) and interferon alpha.
J.Biol.Chem., 282, 2007
3G7B
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BU of 3g7b by Molmil
Staphylococcus aureus Gyrase B co-complex with METHYL ({5-[4-(4-HYDROXYPIPERIDIN-1-YL)-2-PHENYL-1,3-THIAZOL-5-YL]-1H-PYRAZOL-3-YL}METHYL)CARBAMATE inhibitor
分子名称: DNA gyrase subunit B, methyl ({5-[4-(4-hydroxypiperidin-1-yl)-2-phenyl-1,3-thiazol-5-yl]-1H-pyrazol-3-yl}methyl)carbamate
著者Wei, Y, Charisfon, P.
登録日2009-02-09
公開日2010-02-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3G7E
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BU of 3g7e by Molmil
Crystal structure of E. coli Gyrase B co-complexed with PROP-2-YN-1-YL {[5-(4-PIPERIDIN-1-YL-2-PYRIDIN-3-YL-1,3-THIAZOL-5-YL)-1H-PYRAZOL-3-YL]METHYL}CARBAMATE inhibitor
分子名称: DNA gyrase subunit B, prop-2-yn-1-yl {[5-(4-piperidin-1-yl-2-pyridin-3-yl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methyl}carbamate
著者Wei, Y, Charifson, P.
登録日2009-02-09
公開日2010-02-09
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
3G75
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BU of 3g75 by Molmil
Crystal structure of Staphylococcus aureus Gyrase B co-complexed with 4-METHYL-5-[3-(METHYLSULFANYL)-1H-PYRAZOL-5-YL]-2-THIOPHEN-2-YL-1,3-THIAZOLE inhibitor
分子名称: 4-methyl-5-[3-(methylsulfanyl)-1H-pyrazol-5-yl]-2-thiophen-2-yl-1,3-thiazole, DNA gyrase subunit B
著者Wei, Y, Charifson, P.
登録日2009-02-09
公開日2010-02-09
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of pyrazolthiazoles as novel and potent inhibitors of bacterial gyrase.
Bioorg.Med.Chem.Lett., 20, 2010
6BY9
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BU of 6by9 by Molmil
Crystal structure of EHMT1
分子名称: Histone-lysine N-methyltransferase EHMT1, UNKNOWN ATOM OR ION
著者Dong, A, Wei, Y, Li, A, Tempel, W, Han, S, Sunnerhagen, M, Penn, L, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Tong, Y, Structural Genomics Consortium (SGC)
登録日2017-12-20
公開日2018-01-31
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Crystal structure of EHMT1
to be published
2OI0
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BU of 2oi0 by Molmil
Crystal structure analysis 0f the TNF-a Coverting Enzyme (TACE) in complexed with Aryl-sulfonamide
分子名称: (3S)-1-{[4-(BUT-2-YN-1-YLOXY)PHENYL]SULFONYL}PYRROLIDINE-3-THIOL, TNF- a Converting Enzyme (TACE), ZINC ION
著者Wei, Y, Rao, G.B, Bandarage, U.K.
登録日2007-01-10
公開日2007-11-27
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel thiol-based TACE inhibitors: rational design, synthesis, and SAR of thiol-containing aryl sulfonamides
Bioorg.Med.Chem.Lett., 17, 2007
1S16
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BU of 1s16 by Molmil
Crystal Structure of E. coli Topoisomerase IV ParE 43kDa subunit complexed with ADPNP
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, SULFATE ION, ...
著者Wei, Y, Gross, C.H.
登録日2004-01-05
公開日2004-05-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
1S14
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BU of 1s14 by Molmil
Crystal structure of Escherichia coli Topoisomerase IV ParE 24kDa subunit
分子名称: NOVOBIOCIN, Topoisomerase IV subunit B
著者Wei, Y, Gross, C.H.
登録日2004-01-05
公開日2004-05-04
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structures of Escherichia coli topoisomerase IV ParE subunit (24 and 43 kilodaltons): a single residue dictates differences in novobiocin potency against topoisomerase IV and DNA gyrase.
Antimicrob.Agents Chemother., 48, 2004
3B92
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BU of 3b92 by Molmil
Novel thio-based TACE inhibitors Part 2: Rational design, synthesis and SAR of thiol-contaning aryl sufones
分子名称: 3-{[4-(but-2-yn-1-yloxy)phenyl]sulfonyl}propane-1-thiol, ADAM 17, ZINC ION
著者Wei, Y.
登録日2007-11-02
公開日2007-12-18
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Novel thiol-based TACE inhibitors. Part 2: Rational design, synthesis, and SAR of thiol-containing aryl sulfones.
Bioorg.Med.Chem.Lett., 18, 2008
3TKA
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BU of 3tka by Molmil
crystal structure and solution saxs of methyltransferase rsmh from E.coli
分子名称: 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, Ribosomal RNA small subunit methyltransferase H, S-ADENOSYLMETHIONINE, ...
著者Gao, Z.Q, Wei, Y, Zhang, H, Dong, Y.H.
登録日2011-08-25
公開日2012-05-30
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Crystal and solution structures of methyltransferase RsmH provide basis for methylation of C1402 in 16S rRNA.
J.Struct.Biol., 179, 2012
7E7Y
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BU of 7e7y by Molmil
Crystal structure of the SARS-CoV-2 S RBD in complex with BD-623 Fab
分子名称: BD-623 Fab H, BD-623 Fab L, Spike protein S1
著者Wei, Y, Xiao, J.
登録日2021-02-28
公開日2021-06-09
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.41 Å)
主引用文献Humoral immune response to circulating SARS-CoV-2 variants elicited by inactivated and RBD-subunit vaccines.
Cell Res., 31, 2021
5MV2
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BU of 5mv2 by Molmil
Crystal structure of the E protein of the Japanese encephalitis live attenuated vaccine virus
分子名称: E protein
著者Liu, X, Zhao, X, Na, R, Li, L, Warkentin, E, Witt, J, Lu, X, Wei, Y, Peng, G, Li, Y, Wang, J.
登録日2017-01-14
公開日2018-05-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism.
Protein Cell, 10, 2019
5MV1
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BU of 5mv1 by Molmil
Crystal structure of the E protein of the Japanese encephalitis virulent virus
分子名称: E protein
著者Liu, X, Zhao, X, Na, R, Li, L, Warkentin, E, Witt, J, Lu, X, Wei, Y, Peng, G, Li, Y, Wang, J.
登録日2017-01-14
公開日2018-05-23
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献The structure differences of Japanese encephalitis virus SA14 and SA14-14-2 E proteins elucidate the virulence attenuation mechanism.
Protein Cell, 10, 2019
1WAB
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BU of 1wab by Molmil
PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
分子名称: ACETATE ION, PLATELET-ACTIVATING FACTOR ACETYLHYDROLASE
著者Ho, Y.S, Swenson, L, Derewenda, U, Serre, L, Wei, Y, Dauter, Z, Hattori, M, Aoki, J, Arai, H, Adachi, T, Inoue, K, Derewenda, Z.S.
登録日1996-10-30
公開日1997-11-12
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Brain acetylhydrolase that inactivates platelet-activating factor is a G-protein-like trimer.
Nature, 385, 1997
1GG6
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BU of 1gg6 by Molmil
CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-PHENYLALANINE TRIFLUOROMETHYL KETONE BOUND AT THE ACTIVE SITE
分子名称: 1,1,1-TRIFLUORO-3-ACETAMIDO-4-PHENYL BUTAN-2-ONE(N-ACETYL-L-PHENYLALANYL TRIFLUOROMETHYL KETONE), 1,2-ETHANEDIOL, GAMMA CHYMOTRYPSIN, ...
著者Neidhart, D, Wei, Y, Cassidy, C, Lin, J, Cleland, W.W, Frey, P.A.
登録日2000-07-31
公開日2000-09-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin.
Biochemistry, 40, 2001
1GGD
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CRYSTAL STRUCTURE OF GAMMA CHYMOTRYPSIN WITH N-ACETYL-LEUCIL-PHENYLALANINE ALDEHYDE BOUND AT THE ACTIVE SITE
分子名称: 2-ACETYLAMINO-4-METHYL-PENTANOIC ACID (1-FORMYL-2-PHENYL-ETHYL)-AMIDE, GAMMA CHYMOTRYPSIN, SULFATE ION
著者Neidhart, D, Wei, Y, Cassidy, C, Lin, J, Cleland, W.W, Frey, P.A.
登録日2000-08-14
公開日2000-09-20
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Correlation of low-barrier hydrogen bonding and oxyanion binding in transition state analogue complexes of chymotrypsin.
Biochemistry, 40, 2000
2GF5
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BU of 2gf5 by Molmil
Structure of intact FADD (MORT1)
分子名称: FADD protein
著者Carrington, P.E, Sandu, C, Wei, Y, Hill, J.M, Morisawa, G, Huang, T, Gavathiotis, E, Wei, Y, Werner, M.H.
登録日2006-03-21
公開日2006-06-27
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献The Structure of FADD and Its Mode of Interaction with Procaspase-8
Mol.Cell, 22, 2006
1TIB
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BU of 1tib by Molmil
CONFORMATIONAL LABILITY OF LIPASES OBSERVED IN THE ABSENCE OF AN OIL-WATER INTERFACE: CRYSTALLOGRAPHIC STUDIES OF ENZYMES FROM THE FUNGI HUMICOLA LANUGINOSA AND RHIZOPUS DELEMAR
分子名称: LIPASE
著者Derewenda, U, Swenson, L, Wei, Y, Derewenda, Z.S.
登録日1993-12-06
公開日1995-01-26
最終更新日2024-06-05
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Conformational lability of lipases observed in the absence of an oil-water interface: crystallographic studies of enzymes from the fungi Humicola lanuginosa and Rhizopus delemar.
J.Lipid Res., 35, 1994

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