8Y0Y
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![BU of 8y0y by Molmil](/molmil-images/mine/8y0y) | Cryo-EM structure of the 123-316 scDb/PT-RBD complex | 分子名称: | 123-316 scDb, 2-acetamido-2-deoxy-beta-D-glucopyranose, Spike glycoprotein | 著者 | Jia, G.W, Tong, Z, Tong, J.Y, Su, Z.M. | 登録日 | 2024-01-23 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.86 Å) | 主引用文献 | Deciphering a reliable synergistic bispecific strategy of rescuing antibodies for SARS-CoV-2 escape variants, including BA.2.86, EG.5.1, and JN.1. Cell Rep, 43, 2024
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6CRN
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![BU of 6crn by Molmil](/molmil-images/mine/6crn) | Structure of the USP15 deubiquitinase domain in complex with a high-affinity first-generation Ubv | 分子名称: | Ubiquitin carboxyl-terminal hydrolase 15, Ubiquitin variant 15.2, ZINC ION | 著者 | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | 登録日 | 2018-03-19 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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6CPM
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![BU of 6cpm by Molmil](/molmil-images/mine/6cpm) | Structure of the USP15 deubiquitinase domain in complex with a third-generation inhibitory Ubv | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, GLYCEROL, ... | 著者 | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | 登録日 | 2018-03-13 | 公開日 | 2019-01-23 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.011 Å) | 主引用文献 | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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1JPA
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![BU of 1jpa by Molmil](/molmil-images/mine/1jpa) | Crystal Structure of unphosphorylated EphB2 receptor tyrosine kinase and juxtamembrane region | 分子名称: | PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, neural kinase, Nuk=Eph/Elk/Eck family receptor-like tyrosine kinase | 著者 | Wybenga-Groot, L.E, Pawson, T, Sicheri, F. | 登録日 | 2001-08-01 | 公開日 | 2001-10-03 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structural basis for autoinhibition of the Ephb2 receptor tyrosine kinase by the unphosphorylated juxtamembrane region. Cell(Cambridge,Mass.), 106, 2001
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7T1K
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![BU of 7t1k by Molmil](/molmil-images/mine/7t1k) | Crystal structure of a superbinder Fes SH2 domain (sFes1) in complex with a high affinity phosphopeptide | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, MALONATE ION, ... | 著者 | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | 登録日 | 2021-12-02 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
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7T1L
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![BU of 7t1l by Molmil](/molmil-images/mine/7t1l) | Crystal structure of a superbinder Fes SH2 domain (sFesS) in complex with a high affinity phosphopeptide | 分子名称: | CHLORIDE ION, SODIUM ION, Synthetic phosphotyrosine-containing Ezrin-derived peptide, ... | 著者 | Martyn, G.D, Singer, A.U, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | 登録日 | 2021-12-02 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
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7T1U
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![BU of 7t1u by Molmil](/molmil-images/mine/7t1u) | Crystal structure of a superbinder Src SH2 domain (sSrcF) in complex with a high affinity phosphopeptide | 分子名称: | Proto-oncogene tyrosine-protein kinase Src, Synthetic phosphopeptide, ZINC ION | 著者 | Martyn, G.D, Singer, A.U, Manczyk, N, Veggiani, G, Kurinov, I, Sicheri, F, Sidhu, S.S. | 登録日 | 2021-12-02 | 公開日 | 2022-08-24 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Engineered SH2 Domains for Targeted Phosphoproteomics. Acs Chem.Biol., 17, 2022
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5H2C
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![BU of 5h2c by Molmil](/molmil-images/mine/5h2c) | Crystal structure of Saccharomyces cerevisiae Osh1 ANK - Nvj1 | 分子名称: | Nucleus-vacuole junction protein 1, Oxysterol-binding protein homolog 1 | 著者 | Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S. | 登録日 | 2016-10-14 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.508 Å) | 主引用文献 | Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction Structure, 25, 2017
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5H2D
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![BU of 5h2d by Molmil](/molmil-images/mine/5h2d) | Crystal structure of Osh1 ORD domain in complex with ergosterol | 分子名称: | ERGOSTEROL, KLLA0C04147p, SULFATE ION | 著者 | Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S. | 登録日 | 2016-10-14 | 公開日 | 2017-05-10 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction Structure, 25, 2017
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5H2A
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5H28
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5WVR
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![BU of 5wvr by Molmil](/molmil-images/mine/5wvr) | Crystal structure of Osh1 ORD domain in complex with cholesterol | 分子名称: | CHOLESTEROL, KLLA0C04147p, SULFATE ION | 著者 | Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S. | 登録日 | 2016-12-28 | 公開日 | 2017-05-10 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction Structure, 25, 2017
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7XK2
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![BU of 7xk2 by Molmil](/molmil-images/mine/7xk2) | Cryo-EM Structure of Human Niacin Receptor HCA2-Gi protein complex | 分子名称: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, DiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J. | 登録日 | 2022-04-19 | 公開日 | 2023-02-22 | 最終更新日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the human niacin receptor HCA2-G i signalling complex. Nat Commun, 14, 2023
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8HRD
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![BU of 8hrd by Molmil](/molmil-images/mine/8hrd) | Crystal structure of the receptor binding domain of SARS-CoV-2 Delta variant in complex with IMCAS74 Fab and W14 Fab | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IMCAS74 Fab heavy chain, IMCAS74 Fab light chain, ... | 著者 | Zhao, R.C, Wu, L.L, Han, P. | 登録日 | 2022-12-15 | 公開日 | 2023-12-20 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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7YF5
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7Y3N
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![BU of 7y3n by Molmil](/molmil-images/mine/7y3n) | Crystal structure of SARS-CoV receptor binding domain in complex with human antibody BIOLS56 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, ... | 著者 | Rao, X, Chai, Y, Wu, Y, Gao, F. | 登録日 | 2022-06-11 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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7Y3O
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![BU of 7y3o by Molmil](/molmil-images/mine/7y3o) | Crystal structure of SARS-CoV-2 receptor binding domain in complex with human antibody BIOLS56 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of BIOLS56, Light chain of BIOLS56, ... | 著者 | Rao, X, Gao, F, Wu, Y, Gao, F. | 登録日 | 2022-06-11 | 公開日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Defining a de novo non-RBM antibody as RBD-8 and its synergistic rescue of immune-evaded antibodies to neutralize Omicron SARS-CoV-2. Proc.Natl.Acad.Sci.USA, 120, 2023
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4TZI
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![BU of 4tzi by Molmil](/molmil-images/mine/4tzi) | Structure of unliganded Lyn SH2 domain | 分子名称: | Tyrosine-protein kinase Lyn | 著者 | Wybenga-Groot, L.E. | 登録日 | 2014-07-10 | 公開日 | 2015-01-21 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Tyrosine Phosphorylation of the Lyn Src Homology 2 (SH2) Domain Modulates Its Binding Affinity and Specificity. Mol.Cell Proteomics, 14, 2015
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6ML1
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![BU of 6ml1 by Molmil](/molmil-images/mine/6ml1) | Structure of the USP15 deubiquitinase domain in complex with an affinity-matured inhibitory Ubv | 分子名称: | 1,2-ETHANEDIOL, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | 著者 | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | 登録日 | 2018-09-26 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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6DJ9
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![BU of 6dj9 by Molmil](/molmil-images/mine/6dj9) | Structure of the USP15 DUSP domain in complex with a high-affinity Ubiquitin Variant (UbV) | 分子名称: | Ubiquitin Variant UbV 15.D, Ubiquitin carboxyl-terminal hydrolase 15 | 著者 | Singer, A.U, Teyra, J, Boehmelt, G, Lenter, M, Sicheri, F, Sidhu, S.S. | 登録日 | 2018-05-24 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure, 27, 2019
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3V6E
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![BU of 3v6e by Molmil](/molmil-images/mine/3v6e) | Crystal Structure of USP2 and a mutant form of Ubiquitin | 分子名称: | CHLORIDE ION, GLYCEROL, Ubiquitin, ... | 著者 | Neculai, M, Ernst, A, Sidhu, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Weigelt, J, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | 登録日 | 2011-12-19 | 公開日 | 2012-12-19 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A strategy for modulation of enzymes in the ubiquitin system. Science, 339, 2013
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4I6L
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4N9N
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4J7Q
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![BU of 4j7q by Molmil](/molmil-images/mine/4j7q) | Crystal structure of Saccharomyces cerevisiae Sfh3 complexed with phosphatidylinositol | 分子名称: | (1R)-2-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}-1-[(octadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Phosphatidylinositol transfer protein PDR16 | 著者 | Yang, H, Im, Y.J. | 登録日 | 2013-02-14 | 公開日 | 2013-07-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles. Febs Lett., 587, 2013
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4J7P
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![BU of 4j7p by Molmil](/molmil-images/mine/4j7p) | Crystal structure of Saccharomyces cerevisiae Sfh3 | 分子名称: | Phosphatidylinositol transfer protein PDR16 | 著者 | Yang, H, Im, Y.J. | 登録日 | 2013-02-14 | 公開日 | 2013-07-03 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural determinants for phosphatidylinositol recognition by Sfh3 and substrate-induced dimer-monomer transition during lipid transfer cycles. Febs Lett., 587, 2013
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