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Structure of SARS-CoV-2 spike protein receptor binding domain in complex with a potent neutralizing antibody, CV30 Fab
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CV30 Fab Heavy chain, CV30 Fab Kappa chain, ...
著者	Hurlburt, N.K, Pancera, M.
登録日	2020-06-11
公開日	2020-07-01
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.75 Å)
主引用文献	Structural basis for potent neutralization of SARS-CoV-2 and role of antibody affinity maturation. Nat Commun, 11, 2020

7JLN

Crystal structure of glVRC01 Fab in complex with anti-idiotype iv9 Fab
分子名称:	AMMONIUM ION, SODIUM ION, glVRC01 Heavy Chain, ...
著者	Weidle, C, Pancera, M.
登録日	2020-07-30
公開日	2021-03-31
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.57 Å)
主引用文献	Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies. Cell Rep, 35, 2021

7JLK

Crystal structure of glVRC01 Fab in complex with anti-idiotype iv1 scFv
分子名称:	1,2-ETHANEDIOL, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者	Weidle, C, Pancera, M.
登録日	2020-07-29
公開日	2021-03-31
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.99 Å)
主引用文献	Development of a VRC01-class germline targeting immunogen derived from anti-idiotypic antibodies. Cell Rep, 35, 2021

7M3I

Structure of SARS-CoV-2 spike protein receptor binding domain in complex with a neutralizing antibody, CV2-75 Fab
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, CV2-75 Fab Heavy chain, CV2-75 Fab Light chain, ...
著者	Hurlburt, N.K, Pancera, M.
登録日	2021-03-18
公開日	2021-05-12
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	Isolation and characterization of cross-neutralizing coronavirus antibodies from COVID-19+ subjects. Cell Rep, 36, 2021

6ORP

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab897NHP
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab897NHP antibody Fab heavy chain, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.4 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORN

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch bNAb 10-1074
分子名称:	10-1074 antibody Fab heavy chain, 10-1074 antibody Fab light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.05 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORO

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab874NHP
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab874NHP antibody Fab heavy chain, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (3.9 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

6ORQ

Modified BG505 SOSIP-based immunogen RC1 in complex with the elicited V3-glycan patch antibody Ab275MUR
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Ab275MUR antibody Fab heavy chain, ...
著者	Abernathy, M.E, Gristick, H.B, Bjorkman, P.J.
登録日	2019-04-30
公開日	2019-06-12
最終更新日	2020-07-29
実験手法	ELECTRON MICROSCOPY (4.4 Å)
主引用文献	Immunization expands B cells specific to HIV-1 V3 glycan in mice and macaques. Nature, 570, 2019

7RAQ

Crystal structure of CV3-25 Fab bound to SARS-CoV-2 spike stem helix peptide
分子名称:	CV3-25 Fab Heavy Chain, CV3-25 Fab Light Chain, GLYCEROL, ...
著者	Hurlburt, N.K, Pancera, M.
登録日	2021-07-02
公開日	2022-04-13
最終更新日	2023-10-18
実験手法	X-RAY DIFFRACTION (1.74 Å)
主引用文献	Structural definition of a pan-sarbecovirus neutralizing epitope on the spike S2 subunit. Commun Biol, 5, 2022

7RQ6

Cryo-EM structure of SARS-CoV-2 spike in complex with non-neutralizing NTD-directed CV3-13 Fab isolated from convalescent individual
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CV3-13 Fab heavy chain, ...
著者	Chen, Y, Pozharski, E, Tolbert, W.D, Pazgier, M.
登録日	2021-08-05
公開日	2022-04-20
最終更新日	2023-08-09
実験手法	ELECTRON MICROSCOPY (4.18 Å)
主引用文献	A Fc-enhanced NTD-binding non-neutralizing antibody delays virus spread and synergizes with a nAb to protect mice from lethal SARS-CoV-2 infection. Cell Rep, 38, 2022

4M62

Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10
分子名称:	GEP2 FV heavy chain, GEP2 FV light chain, SULFATE ION, ...
著者	Finton, K.A.K.
登録日	2013-08-08
公開日	2014-10-08
実験手法	X-RAY DIFFRACTION (1.8 Å)
主引用文献	Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10. Plos Pathog., 10, 2014

4LRN

Ontogeny of recognition specificity and functionality for the anti-HIV antibody 4E10
分子名称:	GEP 1 heavy chain, GEP 1 light chain
著者	Finton, K.A.K.
登録日	2013-07-20
公開日	2014-10-08
実験手法	X-RAY DIFFRACTION (1.89 Å)
主引用文献	Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10. Plos Pathog., 10, 2014

4M8Q

Ontogeny of recognition specificity and functionality for the anti-HIV neutralizing antibody 4E10
分子名称:	4E10 epitope scaffold T117, GEP1 Fv heavy chain, GEP1 Fv light chain
著者	Finton, K.A.K.
登録日	2013-08-13
公開日	2014-10-08
最終更新日	2018-03-07
実験手法	X-RAY DIFFRACTION (2.89 Å)
主引用文献	Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10. Plos Pathog., 10, 2014

4OB5

Ontogeny of recognition specificity and functionality for the broadly neutralizing anti-HIV antibody 4E10
分子名称:	4E10 antibody germline precursor 7 heavy chain Fv, 4E10 antibody germline precursor 7 light chain Fv, GLYCEROL, ...
著者	Jaffe, J.B, Rupert, P.B.
登録日	2014-01-06
公開日	2014-10-08
実験手法	X-RAY DIFFRACTION (1.7 Å)
主引用文献	Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10. Plos Pathog., 10, 2014

4ODX

4E10 germline encoded precursor no.7 in complex with epitope scaffold T117
分子名称:	4E10 epitope scaffold T117, GEP7 Fv heavy chain, GEP7 Fv light chain
著者	Finton, K.A.K.
登録日	2014-01-10
公開日	2014-10-08
実験手法	X-RAY DIFFRACTION (3.1 Å)
主引用文献	Ontogeny of Recognition Specificity and Functionality for the Broadly Neutralizing Anti-HIV Antibody 4E10. Plos Pathog., 10, 2014

5TF1

Structure of chimeric 02-CC Fab, a VRC01-like germline antibody
分子名称:	02-CC Fab Heavy chain, O2-CC Fab Light Chain
著者	Pancera, M.
登録日	2016-09-23
公開日	2016-11-16
最終更新日	2019-12-11
実験手法	X-RAY DIFFRACTION (1.858 Å)
主引用文献	Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors. Cell Rep, 17, 2016

5TGB

Structure of chimeric 02-CB Fab, a VRC01-like germline antibody
分子名称:	02-CB Fab Heavy Chain, 02-CB Fab Light Chain
著者	Pancera, M.
登録日	2016-09-27
公開日	2016-11-09
最終更新日	2019-12-11
実験手法	X-RAY DIFFRACTION (2.741 Å)
主引用文献	Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors. Cell Rep, 17, 2016

5TFS

Structure of chimeric 02-K Fab, a VRC01-like germline antibody
分子名称:	02-K Fab Heavy chain, 02-K Fab Light chain, SULFATE ION
著者	Pancera, M.
登録日	2016-09-26
公開日	2016-11-09
最終更新日	2019-12-11
実験手法	X-RAY DIFFRACTION (2.319 Å)
主引用文献	Differences in Allelic Frequency and CDRH3 Region Limit the Engagement of HIV Env Immunogens by Putative VRC01 Neutralizing Antibody Precursors. Cell Rep, 17, 2016

5W6D

Crystal structure of BG505-SOSIP.v4.1-GT1-N137A in complex with Fabs 35022 and 9H/109L
分子名称:	109L FAB light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者	Garces, F, Stanfield, R.L, Wilson, I.A.
登録日	2017-06-16
公開日	2017-07-05
最終更新日	2023-10-04
実験手法	X-RAY DIFFRACTION (3.202 Å)
主引用文献	Design and crystal structure of a native-like HIV-1 envelope trimer that engages multiple broadly neutralizing antibody precursors in vivo. J. Exp. Med., 214, 2017

4JKP

Restricting HIV-1 Pathways for Escape using Rationally-Designed Anti-HIV-1 Antibodies
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of antibody 45-46M2, Light chain of antibody 45-46M2, ...
著者	Diskin, R, Bjorkman, P.J.
登録日	2013-03-11
公開日	2013-05-15
最終更新日	2020-07-29
実験手法	X-RAY DIFFRACTION (2.82 Å)
主引用文献	Restricting HIV-1 pathways for escape using rationally designed anti-HIV-1 antibodies. J.Exp.Med., 210, 2013

4JPJ

Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6
著者	Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A.
登録日	2013-03-19
公開日	2013-04-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.5 Å)
主引用文献	Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013

4JPI

Crystal structure of a putative VRC01 germline precursor Fab
分子名称:	GLYCEROL, Putative VRC01 germline Fab heavy chain, Putative VRC01 germline Fab light chain
著者	Julien, J.-P, Diwanji, D.C, Jardine, J, Schief, W.R, Wilson, I.A.
登録日	2013-03-19
公開日	2013-04-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.1 Å)
主引用文献	Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013

4JPK

Crystal structure of the germline-targeting HIV-1 gp120 engineered outer domain eOD-GT6 in complex with a putative VRC01 germline precursor Fab
分子名称:	2-acetamido-2-deoxy-beta-D-glucopyranose, Germline-targeting HIV-1 gp120 engineered outer domain, eOD-GT6, ...
著者	Julien, J.-P, Jardine, J, Schief, W.R, Wilson, I.A.
登録日	2013-03-19
公開日	2013-04-10
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.4 Å)
主引用文献	Rational HIV immunogen design to target specific germline B cell receptors. Science, 340, 2013

3LEF

Crystal structure of HIV epitope-scaffold 4E10_S0_1Z6NA_001
分子名称:	1,2-ETHANEDIOL, Uncharacterized protein 4E10_S0_1Z6NA_001 (T18)
著者	Holmes, M.A.
登録日	2010-01-14
公開日	2010-09-22
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010

3LF6

Crystal structure of HIV epitope-scaffold 4E10_1XIZA_S0_001_N
分子名称:	PHOSPHATE ION, Putative phosphotransferase system
著者	Holmes, M.A.
登録日	2010-01-15
公開日	2010-09-22
最終更新日	2023-09-06
実験手法	X-RAY DIFFRACTION (1.9 Å)
主引用文献	Computational Design of Epitope-Scaffolds Allows Induction of Antibodies Specific for a Poorly Immunogenic HIV Vaccine Epitope. Structure, 18, 2010

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