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5IUD
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BU of 5iud by Molmil
Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer
分子名称: DNA polymerase alpha catalytic subunit, DNA primer, DNA template
著者Coloma, J, Aggarwal, A.K.
登録日2016-03-17
公開日2016-04-13
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.3 Å)
主引用文献Human DNA polymerase alpha in binary complex with a DNA:DNA template-primer.
Sci Rep, 6, 2016
6P1H
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BU of 6p1h by Molmil
Cryo-EM Structure of DNA Polymerase Delta Holoenzyme
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
著者Jain, R, Rice, W, Aggarwal, A.K.
登録日2019-05-19
公開日2019-10-02
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Cryo-EM structure and dynamics of eukaryotic DNA polymerase delta holoenzyme.
Nat.Struct.Mol.Biol., 26, 2019
6Q02
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BU of 6q02 by Molmil
Polymerase Eta-catalyzed insertion of the mismatched A opposite template cytarabine (AraC) residue
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA Primer Strand, DNA polymerase eta, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2019-08-01
公開日2019-11-20
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.09 Å)
主引用文献Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Sci Rep, 9, 2019
6PZ3
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BU of 6pz3 by Molmil
Polymerase Eta-catalyzed insertion of correct G opposite template cytarabine (AraC) residue
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA Primer strand, DNA polymerase eta, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2019-07-31
公開日2019-11-20
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.395 Å)
主引用文献Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase eta.
Sci Rep, 9, 2019
6V8P
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BU of 6v8p by Molmil
Structure of DNA Polymerase Zeta (Apo)
分子名称: DNA polymerase delta small subunit, DNA polymerase delta subunit 3, DNA polymerase zeta catalytic subunit, ...
著者Malik, R, Gomez-Llorente, Y, Ubarretxena-Belandia, I, Aggarwal, A.K.
登録日2019-12-11
公開日2020-08-19
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure and mechanism of B-family DNA polymerase zeta specialized for translesion DNA synthesis.
Nat.Struct.Mol.Biol., 27, 2020
6V93
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BU of 6v93 by Molmil
Structure of DNA Polymerase Zeta/DNA/dNTP Ternary Complex
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA, ...
著者Malik, R, Kopylov, M, Jain, R, Ubarrextena-Belandia, I, Aggarwal, A.K.
登録日2019-12-13
公開日2020-08-19
最終更新日2024-03-06
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structure and mechanism of B-family DNA polymerase zeta specialized for translesion DNA synthesis.
Nat.Struct.Mol.Biol., 27, 2020
6D0M
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BU of 6d0m by Molmil
Polymerase Eta post-insertion binary complex with cytarabine (AraC)
分子名称: DNA (5'-D(*CP*AP*TP*GP*AP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, DNA/RNA (5'-D(*AP*GP*CP*AP*CP*TP*GP*T)-R(P*(CAR))-3'), ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2018-04-10
公開日2018-09-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.832 Å)
主引用文献Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
6D0Z
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BU of 6d0z by Molmil
Polymerase Eta cytarabine (AraC) extension ternary complex
分子名称: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]adenosine, DNA (5'-D(*CP*AP*TP*TP*GP*CP*AP*GP*TP*GP*CP*T)-3'), DNA polymerase eta, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2018-04-11
公開日2018-09-05
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural basis for polymerase eta-promoted resistance to the anticancer nucleoside analog cytarabine.
Sci Rep, 8, 2018
8TLT
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BU of 8tlt by Molmil
Cryo-EM structure of Rev1(deltaN)-Polzeta-DNA-dCTP complex
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*TP*AP*AP*TP*GP*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*GP*AP*AP*T)-3'), ...
著者Malik, R, Aggarwal, A.K.
登録日2023-07-27
公開日2024-05-15
最終更新日2024-10-02
実験手法ELECTRON MICROSCOPY (2.85 Å)
主引用文献Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
Nat.Struct.Mol.Biol., 31, 2024
8TLQ
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BU of 8tlq by Molmil
Cryo-EM structure of the Rev1-Polzeta-DNA-dCTP complex
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
著者Malik, R, Aggarwal, A.K.
登録日2023-07-27
公開日2024-05-15
最終更新日2024-10-02
実験手法ELECTRON MICROSCOPY (3.53 Å)
主引用文献Cryo-EM structure of the Rev1-Pol zeta holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis.
Nat.Struct.Mol.Biol., 31, 2024
7S0T
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BU of 7s0t by Molmil
Structure of DNA polymerase zeta with mismatched DNA
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA (30-MER), ...
著者Malik, R, Ubarretxena, I.B, Aggarwal, A.K.
登録日2021-08-31
公開日2022-03-09
最終更新日2024-06-05
実験手法ELECTRON MICROSCOPY (3.05 Å)
主引用文献Cryo-EM structure of translesion DNA synthesis polymerase zeta with a base pair mismatch.
Nat Commun, 13, 2022
5ULX
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BU of 5ulx by Molmil
Structure of human DNA polymerase iota bound to template 1-methyl-deoxyadenosine crystallized in the presence of dCTP
分子名称: CHLORIDE ION, DNA (5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA (5'-D(P*(MA7)P*GP*GP*GP*TP*CP*CP*T)-3'), ...
著者Jain, R, Aggarwal, A.K.
登録日2017-01-25
公開日2017-04-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.96 Å)
主引用文献Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Sci Rep, 7, 2017
5ULW
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BU of 5ulw by Molmil
Structure of human DNA polymerase iota bound to template 1-methyl-deoxyadenosine
分子名称: CHLORIDE ION, DNA (5'-D(*AP*GP*GP*AP*CP*CP*(DOC))-3'), DNA (5'-D(*TP*(MA7)P*GP*GP*GP*TP*CP*CP*T)-3'), ...
著者Jain, R, Aggarwal, A.K.
登録日2017-01-25
公開日2017-04-19
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.617 Å)
主引用文献Mechanism of error-free DNA synthesis across N1-methyl-deoxyadenosine by human DNA polymerase-iota.
Sci Rep, 7, 2017
3OHA
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BU of 3oha by Molmil
Yeast DNA polymerase eta inserting dCTP opposite an 8oxoG lesion
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(P*TP*(8OG)P*GP*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ...
著者Silverstein, T.D, Jain, R, Aggarwal, A.K.
登録日2010-08-17
公開日2010-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta.
Structure, 18, 2010
3OHB
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BU of 3ohb by Molmil
Yeast DNA polymerase eta extending from an 8-oxoG lesion
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*GP*TP*CP*CP*TP*CP*CP*CP*CP*TP*(DOC))-3', 5'-D(*TP*AP*AP*TP*GP*(8OG)P*AP*GP*GP*GP*GP*AP*GP*GP*AP*C)-3', ...
著者Silverstein, T.D, Jain, R, Aggarwal, A.K.
登録日2010-08-17
公開日2010-12-22
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural basis for error-free replication of oxidatively damaged DNA by yeast DNA polymerase eta.
Structure, 18, 2010
3OSP
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BU of 3osp by Molmil
Structure of rev1
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 5'-D(*AP*TP*CP*CP*TP*CP*CP*CP*CP*TP*AP*(DOC))-3', 5'-D(*TP*AP*AP*(3DR)P*GP*TP*AP*GP*GP*GP*GP*AP*GP*GP*AP*T)-3', ...
著者Nair, D.T, Aggarwal, A.K.
登録日2010-09-09
公開日2011-04-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献DNA synthesis across an abasic lesion by yeast REV1 DNA polymerase.
J.Mol.Biol., 406, 2011
7JK1
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BU of 7jk1 by Molmil
Human PrimPol inserting correct dCTP opposite the 8-oxoguanine lesion
分子名称: 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2020-07-27
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.62 Å)
主引用文献Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JKL
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BU of 7jkl by Molmil
Human PrimPol misinserting dATP opposite the 8-oxoguanine lesion (3'-end base of the primer strand is 2',3'-dideoxy-terminated).
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*CP*(DDG))-3'), ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2020-07-28
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.384 Å)
主引用文献Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JLG
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BU of 7jlg by Molmil
Human PrimPol extending from the erroneous primer base A opposite the 8-oxoguanine lesion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2020-07-29
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JKP
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BU of 7jkp by Molmil
Human PrimPol misinserting dATP opposite the 8-oxoguanine lesion
分子名称: 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, DNA (5'-D(*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*CP*G)-3'), ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2020-07-28
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.592 Å)
主引用文献Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
7JL8
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BU of 7jl8 by Molmil
Human PrimPol extending from the correct primer base C opposite the 8-oxoguanine lesion
分子名称: 1,2-ETHANEDIOL, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, CALCIUM ION, ...
著者Rechkoblit, O, Aggarwal, A.K.
登録日2020-07-29
公開日2021-06-30
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase.
Nat Commun, 12, 2021
3G6V
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BU of 3g6v by Molmil
DNA synthesis across an abasic lesion by human DNA polymerase-iota
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA polymerase iota, MAGNESIUM ION, ...
著者Nair, D.T, Aggarwal, A.K.
登録日2009-02-09
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献DNA Synthesis across an Abasic Lesion by Human DNA Polymerase iota
Structure, 17, 2009
3G6Y
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BU of 3g6y by Molmil
Ternary complex of DNA Polymerase iota:DNA:dTTP with an abasic site at the templating position
分子名称: DNA polymerase iota, MAGNESIUM ION, Primer DNA strand, ...
著者Nair, D.T, Aggarwal, A.K.
登録日2009-02-09
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献DNA Synthesis across an Abasic Lesion by Human DNA Polymerase iota
Structure, 17, 2009
3G6X
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BU of 3g6x by Molmil
Ternary complex of DNA Polymerase iota:DNA:dGTP with an abasic site at the templating position
分子名称: 2'-DEOXYGUANOSINE-5'-TRIPHOSPHATE, DNA polymerase iota, MAGNESIUM ION, ...
著者Nair, D.T, Aggarwal, A.K.
登録日2009-02-09
公開日2009-05-12
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献DNA Synthesis across an Abasic Lesion by Human DNA Polymerase iota.
Structure, 17, 2009
3IN5
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BU of 3in5 by Molmil
Structure of human DNA polymerase kappa inserting dATP opposite an 8-oxoG DNA lesion
分子名称: ADENOSINE-5'-TRIPHOSPHATE, DNA (5'-D(*C*CP*TP*AP*(8OG)P*GP*AP*GP*TP*CP*CP*TP*TP*CP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*G*GP*GP*GP*AP*AP*GP*GP*AP*CP*TP*(DOC))-3'), ...
著者Silverstein, T.D, Vasquez-Del Carpio, R, Aggarwal, A.K.
登録日2009-08-11
公開日2009-09-08
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献Structure of human DNA polymerase kappa inserting dATP opposite an 8-oxoG DNA lesion
PLOS ONE, 4, 2009

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