7JKL
Human PrimPol misinserting dATP opposite the 8-oxoguanine lesion (3'-end base of the primer strand is 2',3'-dideoxy-terminated).
Summary for 7JKL
Entry DOI | 10.2210/pdb7jkl/pdb |
Related | 7JK1 |
Descriptor | DNA-directed primase/polymerase protein, DNA (5'-D(P*AP*(8OG)P*CP*GP*CP*TP*AP*CP*CP*AP*CP*AP*CP*CP*CP*C)-3'), DNA (5'-D(*GP*GP*GP*TP*GP*TP*GP*GP*TP*AP*GP*CP*(DDG))-3'), ... (7 entities in total) |
Functional Keywords | translesion, dna synthesis, dna replication, dna damage, transferase, transferase-dna complex, transferase/dna |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 6 |
Total formula weight | 101695.66 |
Authors | Rechkoblit, O.,Aggarwal, A.K. (deposition date: 2020-07-28, release date: 2021-06-30, Last modification date: 2023-10-18) |
Primary citation | Rechkoblit, O.,Johnson, R.E.,Gupta, Y.K.,Prakash, L.,Prakash, S.,Aggarwal, A.K. Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase. Nat Commun, 12:4020-4020, 2021 Cited by PubMed: 34188055DOI: 10.1038/s41467-021-24317-z PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.384 Å) |
Structure validation
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