7JKL
Human PrimPol misinserting dATP opposite the 8-oxoguanine lesion (3'-end base of the primer strand is 2',3'-dideoxy-terminated).
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| A | 0003896 | molecular_function | DNA primase activity |
| A | 0006269 | biological_process | DNA replication, synthesis of primer |
| A | 0042276 | biological_process | error-prone translesion synthesis |
| B | 0003887 | molecular_function | DNA-directed DNA polymerase activity |
| B | 0003896 | molecular_function | DNA primase activity |
| B | 0006269 | biological_process | DNA replication, synthesis of primer |
| B | 0042276 | biological_process | error-prone translesion synthesis |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 8 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:27819052, ECO:0007744|PDB:5L2X |
| Chain | Residue | Details |
| A | ARG76 | |
| A | LYS165 | |
| A | ARG288 | |
| A | LYS297 | |
| B | ARG76 | |
| B | LYS165 | |
| B | ARG288 | |
| B | LYS297 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:24126761, ECO:0000305|PubMed:27819052, ECO:0007744|PDB:5L2X |
| Chain | Residue | Details |
| A | ASP114 | |
| B | ASP114 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000305|PubMed:27819052, ECO:0007744|PDB:5L2X |
| Chain | Residue | Details |
| A | GLU116 | |
| B | GLU116 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332, ECO:0007744|PubMed:23186163 |
| Chain | Residue | Details |
| A | SER255 | |
| B | SER255 |
