5LLS
 
 | | Porcine dipeptidyl peptidase IV in complex with 8-(3-aminopiperidin-1-yl)-7-[(2-bromophenyl)methyl]-1,3-dimethyl-2,3,6,7-tetrahydro-1H-purine-2,6-dione | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3~{R})-3-azanylpiperidin-1-yl]-7-[(2-bromophenyl)methyl]-1,3-dimethyl-purine-2,6-dione, ... | | 著者 | Nar, H, Blaesse, M. | | 登録日 | 2016-07-28 | | 公開日 | 2016-09-14 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | | 主引用文献 | Comparative Analysis of Binding Kinetics and Thermodynamics of Dipeptidyl Peptidase-4 Inhibitors and Their Relationship to Structure.
J.Med.Chem., 59, 2016
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2RGU
 | | Crystal structure of complex of human DPP4 and inhibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8-[(3R)-3-Aminopiperidin-1-yl]-7-but-2-yn-1-yl-3-methyl-1-[(4-methylquinazolin-2-yl)methyl]-3,7-dihydro-1H-purine-2,6-d ione, Dipeptidyl peptidase 4 | | 著者 | Nar, H, Himmelsbach, F, Eckhardt, M. | | 登録日 | 2007-10-05 | | 公開日 | 2007-11-06 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | 8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a Highly Potent, Selective, Long-Acting, and Orally Bioavailable DPP-4 Inhibitor for the Treatment of Type 2 Diabetes.
J.Med.Chem., 50, 2007
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3E5V
 | | Crystal Structure Analysis of eqFP611 Double Mutant T122R, N143S | | 分子名称: | Red fluorescent protein eqFP611 | | 著者 | Nar, H, Nienhaus, K, Nienhaus, U, Wiedenmann, J. | | 登録日 | 2008-08-14 | | 公開日 | 2008-09-23 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Trans-cis isomerization is responsible for the red-shifted fluorescence in variants of the red fluorescent protein eqFP611.
J.Am.Chem.Soc., 130, 2008
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3E5T
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1ZUX
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3AZU
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2BTJ
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4K8B
 | | Crystal structure of HCV NS3/4A protease complexed with inhibitor | | 分子名称: | N-(tert-butylcarbamoyl)-3-methyl-L-valyl-(4R)-N-[(1R,2S)-1-carboxy-2-ethenylcyclopropyl]-4-[(7-methoxy-2-phenylquinolin-4-yl)oxy]-L-prolinamide, NS3 protease, Nonstructural protein, ... | | 著者 | Nar, H. | | 登録日 | 2013-04-18 | | 公開日 | 2014-03-26 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Ligand bioactive conformation plays a critical role in the design of drugs that target the hepatitis C virus NS3 protease.
J.Med.Chem., 57, 2014
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5F2P
 | | Crystal structure of the BRD9 bromodomain in complex with compound 3. | | 分子名称: | 2-(dimethylamino)-6-methyl-pyrido[4,3-d]pyrimidin-5-one, BRD9 | | 著者 | Nar, H, Fiegen, D, Zoephel, A, Bader, G. | | 登録日 | 2015-12-02 | | 公開日 | 2016-03-09 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structure-Based Design of an in Vivo Active Selective BRD9 Inhibitor.
J.Med.Chem., 59, 2016
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1A9C
 | | GTP CYCLOHYDROLASE I (C110S MUTANT) IN COMPLEX WITH GTP | | 分子名称: | GTP CYCLOHYDROLASE I, GUANOSINE-5'-TRIPHOSPHATE | | 著者 | Auerbach, G, Nar, H, Bracher, A, Bacher, A, Huber, R. | | 登録日 | 1998-04-04 | | 公開日 | 1999-05-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | GTP Cyclohydrolase I in Complex with GTP at 2.1 A Resolution
To be Published
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1A8R
 | | GTP CYCLOHYDROLASE I (H112S MUTANT) IN COMPLEX WITH GTP | | 分子名称: | GTP CYCLOHYDROLASE I, GUANOSINE-5'-TRIPHOSPHATE | | 著者 | Auerbach, G, Nar, H, Bracher, A, Bacher, A, Huber, R. | | 登録日 | 1998-03-27 | | 公開日 | 1999-05-11 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Biosynthesis of pteridines. Reaction mechanism of GTP cyclohydrolase I.
J.Mol.Biol., 326, 2003
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1AZR
 | | CRYSTAL STRUCTURE OF PSEUDOMONAS AERUGINOSA ZINC AZURIN MUTANT ASP47ASP AT 2.4 ANGSTROMS RESOLUTION | | 分子名称: | AZURIN, COPPER (II) ION, NITRATE ION | | 著者 | Sjolin, L, Tsai, Lc, Langer, V, Pascher, T, Karlsson, G, Nordling, M, Nar, H. | | 登録日 | 1993-03-04 | | 公開日 | 1993-07-15 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structure of Pseudomonas aeruginosai zinc azurin mutant Asn47Asp at 2.4 A resolution.
Acta Crystallogr.,Sect.D, 49, 1993
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1AZN
 | | CRYSTAL STRUCTURE OF THE AZURIN MUTANT PHE114ALA FROM PSEUDOMONAS AERUGINOSA AT 2.6 ANGSTROMS RESOLUTION | | 分子名称: | AZURIN, COPPER (II) ION | | 著者 | Tsai, L.-C, Sjolin, L, Langer, V, Pascher, T, Nar, H. | | 登録日 | 1994-05-27 | | 公開日 | 1994-10-15 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Structure of the azurin mutant Phe114Ala from Pseudomonas aeruginosa at 2.6 A resolution.
Acta Crystallogr.,Sect.D, 51, 1995
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8C7H
 | | Cryo-EM Map of the latTGF-beta 28G11 Fab complex | | 分子名称: | 28G11 Fab heavy chain, 28G11 Fab light chain, Transforming growth factor beta activator LRRC32, ... | | 著者 | Ebenhoch, R, Nar, H. | | 登録日 | 2023-01-16 | | 公開日 | 2023-03-01 | | 最終更新日 | 2023-03-29 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Anti-GARP Antibodies Inhibit Release of TGF-beta by Regulatory T Cells via Different Modes of Action, but Do Not Influence Their Function In Vitro.
Immunohorizons, 7, 2023
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1B6Z
 | | 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE | | 分子名称: | 6-pyruvoyl tetrahydropterin synthase, ZINC ION | | 著者 | Ploom, T, Thoeny, B, Yim, J, Lee, S, Nar, H, Leimbacher, W, Huber, R, Richardson, J, Auerbach, G. | | 登録日 | 1999-01-18 | | 公開日 | 2000-01-21 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
J.Mol.Biol., 286, 1999
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1B66
 | | 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE | | 分子名称: | 6-PYRUVOYL TETRAHYDROPTERIN SYNTHASE, BIOPTERIN, ZINC ION | | 著者 | Ploom, T, Thoeny, B, Yim, J, Lee, S, Nar, H, Leimbacher, W, Huber, R, Richardson, J, Auerbach, G. | | 登録日 | 1999-01-20 | | 公開日 | 1999-04-27 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystallographic and kinetic investigations on the mechanism of 6-pyruvoyl tetrahydropterin synthase.
J.Mol.Biol., 286, 1999
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1NZR
 | | CRYSTAL STRUCTURE OF THE AZURIN MUTANT NICKEL-TRP48MET FROM PSEUDOMONAS AERUGINOSA AT 2.2 ANGSTROMS RESOLUTION | | 分子名称: | AZURIN, NICKEL (II) ION, NITRATE ION | | 著者 | Tsai, L.-C, Sjolin, L, Langer, V, Bonander, N, Karlsson, B.G, Vanngard, T, Hammann, C, Nar, H. | | 登録日 | 1994-12-09 | | 公開日 | 1995-02-27 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structure of the azurin mutant nickel-Trp48Met from Pseudomonas aeruginosa at 2.2 A resolution.
Acta Crystallogr.,Sect.D, 51, 1995
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7NM2
 | | Solution structure of MLKL executioner domain in complex with a fragment | | 分子名称: | 2-[(~{S})-methoxy-(4-propan-2-ylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2021-02-23 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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7NM4
 | | Solution structure of MLKL executioner domain in complex with a fragment | | 分子名称: | (~{S})-1~{H}-benzimidazol-2-yl-(4-propan-2-ylphenyl)methanol, Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2021-02-23 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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7NM5
 | | Solution structure of MLKL executioner domain in complex with a fragment | | 分子名称: | 2-[(~{S})-methoxy-(4-phenylphenyl)methyl]-3~{H}-benzimidazole-5-carboxylic acid, Mixed lineage kinase domain-like protein | | 著者 | Ruebbelke, M, Bauer, M, Hamilton, J, Binder, F, Nar, H, Zeeb, M. | | 登録日 | 2021-02-23 | | 公開日 | 2021-09-22 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Discovery and Structure-Based Optimization of Fragments Binding the Mixed Lineage Kinase Domain-like Protein Executioner Domain.
J.Med.Chem., 64, 2021
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1JQH
 | | IGF-1 receptor kinase domain | | 分子名称: | IGF-1 receptor kinase, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | | 著者 | Pautsch, A, Zoephel, A, Ahorn, H, Spevak, W, Hauptmann, R, Nar, H. | | 登録日 | 2001-08-07 | | 公開日 | 2002-04-19 | | 最終更新日 | 2021-11-10 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Crystal structure of bisphosphorylated IGF-1 receptor kinase: insight into domain movements upon kinase activation.
Structure, 9, 2001
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1ILU
 | | X-RAY CRYSTAL STRUCTURE THE TWO SITE-SPECIFIC MUTANTS ILE7SER AND PHE110SER OF AZURIN FROM PSEUDOMONAS AERUGINOSA | | 分子名称: | AZURIN, COPPER (II) ION | | 著者 | Hammann, C, Nar, H, Huber, R, Messerschmidt, A. | | 登録日 | 1995-10-12 | | 公開日 | 1996-03-08 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray crystal structure of the two site-specific mutants Ile7Ser and Phe110Ser of azurin from Pseudomonas aeruginosa.
J.Mol.Biol., 255, 1996
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1ILS
 | | X-RAY CRYSTAL STRUCTURE THE TWO SITE-SPECIFIC MUTANTS ILE7SER AND PHE110SER OF AZURIN FROM PSEUDOMONAS AERUGINOSA | | 分子名称: | AZURIN, COPPER (II) ION, NITRATE ION | | 著者 | Hammann, C, Nar, H, Huber, R, Messerschmidt, A. | | 登録日 | 1995-10-12 | | 公開日 | 1996-03-08 | | 最終更新日 | 2021-11-03 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | X-ray crystal structure of the two site-specific mutants Ile7Ser and Phe110Ser of azurin from Pseudomonas aeruginosa.
J.Mol.Biol., 255, 1996
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1VLX
 | | STRUCTURE OF ELECTRON TRANSFER (COBALT-PROTEIN) | | 分子名称: | AZURIN, COBALT (II) ION | | 著者 | Bonander, N, Vanngard, T, Tsai, L.-C, Langer, V, Nar, H, Sjolin, L. | | 登録日 | 1996-10-08 | | 公開日 | 1997-03-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | The metal site of Pseudomonas aeruginosa azurin, revealed by a crystal structure determination of the Co(II) derivative and Co-EPR spectroscopy.
Proteins, 27, 1997
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1ETJ
 | | AZURIN MUTANT WITH MET 121 REPLACED BY GLU | | 分子名称: | AZURIN, COPPER (II) ION | | 著者 | Karlsson, B.G, Tsai, L.-C, Nar, H, Sanders-Loehr, J, Bonander, N, Langer, V, Sjolin, L. | | 登録日 | 1997-01-11 | | 公開日 | 1997-04-21 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | X-ray structure determination and characterization of the Pseudomonas aeruginosa azurin mutant Met121Glu.
Biochemistry, 36, 1997
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