1KTS

Thrombin Inhibitor Complex

Summary for 1KTS

• Entry DOI: 10.2210/pdb1kts/pdb
• Related: 1G30 1G32 1KTT
• Descriptor: thrombin, hirudin IIB, 3-({2-[(4-CARBAMIMIDOYL-PHENYLAMINO)-METHYL]-3-METHYL-3H-BENZOIMIDAZOLE-5-CARBONYL}-PYRIDIN-2-YL-AMINO)-PROPIONIC ACID ETHYL ESTER, ... (5 entities in total)
• Functional Keywords: blood coagulation, inhibition, blood clotting, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734; Secreted: P28506
• Total number of polymer chains: 3
• Total formula weight: 35867.84

Authors

Nar, H. (deposition date: 2002-01-17, release date: 2002-02-06, Last modification date: 2013-03-13)

• Primary citation: Hauel, N.H.,Nar, H.,Priepke, H.,Ries, U.,Stassen, J.M.,Wienen, W.; Structure-based design of novel potent nonpeptide thrombin inhibitors.; J.Med.Chem., 45:1757-1766, 2002; PubMed: 11960487; DOI: 10.1021/jm0109513

Experimental method

X-RAY DIFFRACTION (2.4 Å)