8PM9
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![BU of 8pm9 by Molmil](/molmil-images/mine/8pm9) | Crystal structure of human wild type transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) | 分子名称: | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | 登録日 | 2023-06-28 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
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8PM8
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![BU of 8pm8 by Molmil](/molmil-images/mine/8pm8) | V30M Transthyretin structure in complex with Tolcalpone | 分子名称: | Tolcapone, Transthyretin | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | 登録日 | 2023-06-28 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
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8PMO
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![BU of 8pmo by Molmil](/molmil-images/mine/8pmo) | Crystal structure of human V122I transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) | 分子名称: | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | 登録日 | 2023-06-29 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.24 Å) | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
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8PMA
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![BU of 8pma by Molmil](/molmil-images/mine/8pma) | Crystal structure of human V30M transthyretin in complex with PITB (Pharmacokinetically Improved TTR Binder) | 分子名称: | (3-fluoranyl-5-oxidanyl-phenyl)-(3-methoxy-5-nitro-4-oxidanyl-phenyl)methanone, Transthyretin | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | 登録日 | 2023-06-28 | 公開日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | PITB: A high affinity transthyretin aggregation inhibitor with optimal pharmacokinetic properties. Eur.J.Med.Chem., 261, 2023
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7L07
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![BU of 7l07 by Molmil](/molmil-images/mine/7l07) | Last common ancestor of HMPPK and PLK/HMPPK vitamin kinases | 分子名称: | ALUMINUM FLUORIDE, Ancestral Protein AncC | 著者 | Gonzalez-Ordenes, F, Maturana, P, Herrera-Morande, A, Araya, G, Arizabalos, S, Castro-Fernandez, V. | 登録日 | 2020-12-11 | 公開日 | 2021-02-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure and molecular dynamics simulations of a promiscuous ancestor reveal residues and an epistatic interaction involved in substrate binding and catalysis in the ATP-dependent vitamin kinase family members. Protein Sci., 30, 2021
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3IQ5
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![BU of 3iq5 by Molmil](/molmil-images/mine/3iq5) | |
3IQ6
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![BU of 3iq6 by Molmil](/molmil-images/mine/3iq6) | |
6C8Z
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![BU of 6c8z by Molmil](/molmil-images/mine/6c8z) | Last common ancestor of ADP-dependent phosphofructokinases from Methanosarcinales | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADP-dependent phosphofructokinase, MAGNESIUM ION, ... | 著者 | Castro-Fernandez, V, Gonzalez-Ordenes, F, Munoz, S, Fuentes, N, Leonardo, D, Fuentealba, M, Herrera-Morande, A, Maturana, P, Villalobos, P, Garratt, R. | 登録日 | 2018-01-25 | 公開日 | 2018-02-07 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.86 Å) | 主引用文献 | ADP-Dependent Kinases From the Archaeal OrderMethanosarcinalesAdapt to Salt by a Non-canonical Evolutionarily Conserved Strategy. Front Microbiol, 9, 2018
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6VVU
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![BU of 6vvu by Molmil](/molmil-images/mine/6vvu) | Anti-Tryptase fab E104.v1 bound to tryptase | 分子名称: | CALCIUM ION, Fab E104.v1 heavy chain, Fab E104.v1 light chain, ... | 著者 | Ultsch, M, Koerber, J.T. | 登録日 | 2020-02-18 | 公開日 | 2020-12-30 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Bivalent antibody pliers inhibit beta-tryptase by an allosteric mechanism dependent on the IgG hinge. Nat Commun, 11, 2020
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6F60
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![BU of 6f60 by Molmil](/molmil-images/mine/6f60) | The x-ray structure of bovine pancreatic ribonuclease in complex with a five-coordinate platinum(II) compound containing a sugar ligand | 分子名称: | Ribonuclease pancreatic, SULFATE ION, five-coordinate platinum(II) compound | 著者 | Merlino, A, Ferraro, G. | 登録日 | 2017-12-04 | 公開日 | 2018-04-25 | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | 主引用文献 | Five-Coordinate Platinum(II) Compounds Containing Sugar Ligands: Synthesis, Characterization, Cytotoxic Activity, and Interaction with Biological Macromolecules. Inorg Chem, 57, 2018
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3M79
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6XAT
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![BU of 6xat by Molmil](/molmil-images/mine/6xat) | Crystal structure of the human FoxP4 DNA binding Domain | 分子名称: | FOXP4 protein, SODIUM ION | 著者 | VIllalobos, P, Castro-Fernandez, V, Medina, E, Gonzalez-Ordenes, F, Maturana, P, Herrera-Morande, A, Ramirez-Sarmiento, C.A, Babul, J. | 登録日 | 2020-06-04 | 公開日 | 2021-06-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Unraveling the folding and dimerization properties of the human FoxP subfamily of transcription factors. Febs Lett., 597, 2023
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6XIO
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![BU of 6xio by Molmil](/molmil-images/mine/6xio) | ADP-dependent kinase complex with fructose-6-phosphate and ADPbetaS | 分子名称: | 5'-O-[(R)-HYDROXY(THIOPHOSPHONOOXY)PHOSPHORYL]ADENOSINE, 6-O-phosphono-beta-D-fructofuranose, ADP-dependent phosphofructokinase, ... | 著者 | Munoz, S, Gonzalez-Ordenes, F, Fuentes, N, Maturana, P, Herrera-Morande, A, Villalobos, P, Castro-Fernandez, V. | 登録日 | 2020-06-20 | 公開日 | 2021-01-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.12 Å) | 主引用文献 | Structure of an ancestral ADP-dependent kinase with fructose-6P reveals key residues for binding, catalysis, and ligand-induced conformational changes. J.Biol.Chem., 296, 2020
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6XEQ
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![BU of 6xeq by Molmil](/molmil-images/mine/6xeq) | Crystal structure of the tetrameric 6-phosphogluconate dehydrogenase from Gluconobacter oxidans | 分子名称: | 6-phosphogluconate dehydrogenase, SULFATE ION | 著者 | Maturana, P, Roversi, P, Castro-Fernandez, V, Herrera-Morande, A, Garratt, R.C, Cabrera, R. | 登録日 | 2020-06-13 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Crystal structure of the 6-phosphogluconate dehydrogenase from Gluconobacter oxydans reveals tetrameric 6PGDHs as the crucial intermediate in the evolution of structure and cofactor preference in the 6PGDH family [version 1; peer review: 1 approved, 1 approved with reservations] Wellcome Open Res, 6, 2021
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6DXG
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![BU of 6dxg by Molmil](/molmil-images/mine/6dxg) | amidobenzimidazole (ABZI) STING agonists | 分子名称: | 2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1-[(2R)-2-hydroxy-2-phenylethyl]-1H-benzimidazole-5-carboxamide, CALCIUM ION, Stimulator of interferon protein | 著者 | Concha, N.O. | 登録日 | 2018-06-28 | 公開日 | 2018-11-07 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.905 Å) | 主引用文献 | Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature, 564, 2018
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6DXL
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![BU of 6dxl by Molmil](/molmil-images/mine/6dxl) | Linked amidobenzimidazole STING agonist | 分子名称: | 1,1'-(butane-1,4-diyl)bis{2-[(1-ethyl-3-methyl-1H-pyrazole-5-carbonyl)amino]-1H-benzimidazole-5-carboxamide}, CALCIUM ION, Stimulator of interferon protein | 著者 | Concha, N.O. | 登録日 | 2018-06-29 | 公開日 | 2018-11-07 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.45 Å) | 主引用文献 | Design of amidobenzimidazole STING receptor agonists with systemic activity. Nature, 564, 2018
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6VMJ
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6VMK
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4ESR
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![BU of 4esr by Molmil](/molmil-images/mine/4esr) | Molecular and Structural Characterization of the SH3 Domain of AHI-1 in Regulation of Cellular Resistance of BCR-ABL+ Chronic Myeloid Leukemia Cells to Tyrosine Kinase Inhibitors | 分子名称: | DI(HYDROXYETHYL)ETHER, Jouberin | 著者 | Van Petegem, X.F, Liu, P.X, Lobo, P, Jiang, X. | 登録日 | 2012-04-23 | 公開日 | 2012-06-06 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | 主引用文献 | Molecular and structural characterization of the SH3 domain of AHI-1 in regulation of cellular resistance of BCR-ABL(+) chronic myeloid leukemia cells to tyrosine kinase inhibitors. Proteomics, 12, 2012
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