7L07
Last common ancestor of HMPPK and PLK/HMPPK vitamin kinases
Summary for 7L07
| Entry DOI | 10.2210/pdb7l07/pdb |
| Descriptor | Ancestral Protein AncC, ALUMINUM FLUORIDE (3 entities in total) |
| Functional Keywords | ancestral sequence reconstruction, hydroxymethylpyrimidine kinase, pyridoxal kinase, transferase |
| Biological source | synthetic construct |
| Total number of polymer chains | 1 |
| Total formula weight | 30318.09 |
| Authors | Gonzalez-Ordenes, F.,Maturana, P.,Herrera-Morande, A.,Araya, G.,Arizabalos, S.,Castro-Fernandez, V. (deposition date: 2020-12-11, release date: 2021-02-17, Last modification date: 2023-10-18) |
| Primary citation | Gonzalez-Ordenes, F.,Bravo-Moraga, F.,Gonzalez, E.,Hernandez-Cabello, L.,Alzate-Morales, J.,Guixe, V.,Castro-Fernandez, V. Crystal structure and molecular dynamics simulations of a promiscuous ancestor reveal residues and an epistatic interaction involved in substrate binding and catalysis in the ATP-dependent vitamin kinase family members. Protein Sci., 30:842-854, 2021 Cited by PubMed: 33555078DOI: 10.1002/pro.4040 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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