7YWA
| Structure of DinI in complex with RecA filament | 分子名称: | DNA (5'-D(P*TP*TP*TP*TP*TP*T)-3'), DNA damage-inducible protein I, MAGNESIUM ION, ... | 著者 | Gao, B, Feng, Y. | 登録日 | 2022-08-22 | 公開日 | 2022-12-21 | 最終更新日 | 2023-01-18 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural basis for regulation of SOS response in bacteria. Proc.Natl.Acad.Sci.USA, 120, 2023
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4DXD
| Staphylococcal Aureus FtsZ in complex with 723 | 分子名称: | 3-[(6-chloro[1,3]thiazolo[5,4-b]pyridin-2-yl)methoxy]-2,6-difluorobenzamide, Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE | 著者 | Lu, J, Soisson, S.M. | 登録日 | 2012-02-27 | 公開日 | 2012-05-23 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Restoring methicillin-resistant Staphylococcus aureus susceptibility to beta-lactam antibiotics. Sci Transl Med, 4, 2012
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7R1V
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7R1W
| E. coli BAM complex (BamABCDE) bound to dynobactin A | 分子名称: | Dynobactin A, Outer membrane protein assembly factor BamA, Outer membrane protein assembly factor BamB, ... | 著者 | Jakob, R.P, Hiller, S, Maier, T. | 登録日 | 2022-02-03 | 公開日 | 2022-09-28 | 最終更新日 | 2024-04-03 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol, 7, 2022
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3WRN
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3WRR
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3WRS
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3WRQ
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3WRO
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2RHU
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2RI7
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2RI5
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2RI2
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2RHI
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2RHY
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2RHX
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2RI3
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2RHZ
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8GRM
| Cryo-EM structure of PRC1 bound to H2AK119-UbcH5b-Ub nucleosome | 分子名称: | COMMD3 protein, DNA (144-MER), DNA (145-MER), ... | 著者 | Ai, H.S, Zebin, T, Zhihend, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | 登録日 | 2022-09-02 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.05 Å) | 主引用文献 | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023
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8GRQ
| Cryo-EM structure of BRCA1/BARD1 bound to H2AK127-UbcH5c-Ub nucleosome | 分子名称: | BRCA1-associated RING domain protein 1, Breast cancer type 1 susceptibility protein, DNA (147-MER), ... | 著者 | Ai, H.S, Zebin, T, Zhiheng, D, Jiakun, T, Liying, Z, Jia-Bin, L, Man, P, Liu, L. | 登録日 | 2022-09-02 | 公開日 | 2023-04-12 | 実験手法 | ELECTRON MICROSCOPY (3.87 Å) | 主引用文献 | Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination. Chem, 2023
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3MYG
| Aurora A Kinase complexed with SCH 1473759 | 分子名称: | 2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol, Serine/threonine-protein kinase 6, TETRAETHYLENE GLYCOL | 著者 | Hruza, A, Prosis, W, Ramanathan, L. | 登録日 | 2010-05-10 | 公開日 | 2010-07-21 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett, 1, 2010
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7T3H
| MicroED structure of Dynobactin | 分子名称: | TRP-ASN-SER-ASN-VAL-HIS-SER-TYR-ARG-PHE | 著者 | Yoo, B.-K, Kaiser, J.T, Rees, D.C, Miller, R.D, Iinishi, A, Lewis, K, Bowman, S. | 登録日 | 2021-12-07 | 公開日 | 2022-10-19 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.05 Å) | 主引用文献 | Computational identification of a systemic antibiotic for gram-negative bacteria. Nat Microbiol, 7, 2022
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7UGW
| M. tuberculosis DNA gyrase cleavage core bound to DNA and evybactin | 分子名称: | DNA (46-MER), DNA gyrase subunit A, DNA gyrase subunit B, ... | 著者 | Hauk, G, Imai, Y, Lewis, K, Berger, J.M. | 登録日 | 2022-03-25 | 公開日 | 2022-08-17 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Evybactin is a DNA gyrase inhibitor that selectively kills Mycobacterium tuberculosis. Nat.Chem.Biol., 18, 2022
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4MQ1
| The crystal structure of DYRK1a with a bound pyrido[2,3-d]pyrimidine inhibitor | 分子名称: | Dual specificity tyrosine-phosphorylation-regulated kinase 1A, N-(5-{[(1R)-3-amino-1-(3-chlorophenyl)propyl]carbamoyl}-2-chlorophenyl)-2-methoxy-7-oxo-7,8-dihydropyrido[2,3-d]pyrimidine-6-carboxamide, PENTAETHYLENE GLYCOL, ... | 著者 | Lukacs, C.M, Janson, C.A, Garvie, C, Liang, L. | 登録日 | 2013-09-15 | 公開日 | 2013-12-11 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Pyrido[2,3-d]pyrimidines: Discovery and preliminary SAR of a novel series of DYRK1B and DYRK1A inhibitors. Bioorg.Med.Chem.Lett., 23, 2013
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6K9N
| Rice_OTUB_like_catalytic domain | 分子名称: | Ubiquitin thioesterase | 著者 | Lu, L.N, Liu, L, Wang, F. | 登録日 | 2019-06-17 | 公開日 | 2020-06-24 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Met1-specific motifs conserved in OTUB subfamily of green plants enable rice OTUB1 to hydrolyse Met1 ubiquitin chains Nat Commun, 13, 2022
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