4FH0
| Crystal Structure of Human BinCARD CARD, double mutant F16M/L66M SeMet form | 分子名称: | Bcl10-interacting CARD protein, SULFATE ION | 著者 | Chen, K.-E, Kobe, B, Martin, J.L. | 登録日 | 2012-06-05 | 公開日 | 2013-02-06 | 最終更新日 | 2018-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallogr.,Sect.D, 69, 2013
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4V3A
| Membrane bound pleurotolysin prepore (TMH1 lock) trapped with engineered disulphide cross-link | 分子名称: | PLEUROTOLYSIN A, PLEUROTOLYSIN B | 著者 | Lukoyanova, N, Kondos, S.C, Farabella, I, Law, R.H.P, Reboul, C.F, CaradocDavies, T.T, Spicer, B.A, Kleifeld, O, Perugini, M, Ekkel, S, Hatfaludi, T, Oliver, K, Hotze, E.M, Tweten, R.K, Whisstock, J.C, Topf, M, Dunstone, M.A, Saibil, H.R. | 登録日 | 2014-10-17 | 公開日 | 2015-02-18 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (15 Å) | 主引用文献 | Conformational Changes During Pore Formation by the Perforin-Related Protein Pleurotolysin. Plos Biol., 13, 2015
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3DA8
| Crystal structure of PurN from Mycobacterium tuberculosis | 分子名称: | BETA-MERCAPTOETHANOL, IODIDE ION, MAGNESIUM ION, ... | 著者 | Zhang, Z, Squire, C.J, Baker, E.N. | 登録日 | 2008-05-28 | 公開日 | 2009-05-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. J.Mol.Biol., 389, 2009
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3DCJ
| Crystal structure of glycinamide formyltransferase (PurN) from Mycobacterium tuberculosis in complex with 5-methyl-5,6,7,8-tetrahydrofolic acid derivative | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[4-({[(6S)-2-AMINO-4-HYDROXY-5-METHYL-5,6,7,8-TETRAHYDROPTERIDIN-6-YL]METHYL}AMINO)BENZOYL]-L-GLUTAMIC ACID, ... | 著者 | Zhang, Z, Squire, C.J, Baker, E.N. | 登録日 | 2008-06-03 | 公開日 | 2009-05-12 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of glycinamide ribonucleotide transformylase (PurN) from Mycobacterium tuberculosis reveal a novel dimer with relevance to drug discovery. J.Mol.Biol., 389, 2009
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3KQZ
| Structure of a protease 2 | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.39 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KQX
| Structure of a protease 1 | 分子名称: | CARBONATE ION, M17 leucyl aminopeptidase, NONAETHYLENE GLYCOL, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KR4
| Structure of a protease 3 | 分子名称: | 2-(3-AMINO-2-HYDROXY-4-PHENYL-BUTYRYLAMINO)-4-METHYL-PENTANOIC ACID, CARBONATE ION, M17 leucyl aminopeptidase, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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3KR5
| Structure of a protease 4 | 分子名称: | (2S)-3-[(R)-[(1S)-1-amino-3-phenylpropyl](hydroxy)phosphoryl]-2-benzylpropanoic acid, CARBONATE ION, M17 leucyl aminopeptidase, ... | 著者 | McGowan, S, Whisstock, J.C. | 登録日 | 2009-11-17 | 公開日 | 2010-02-02 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Structure of the Plasmodium falciparum M17 aminopeptidase and significance for the design of drugs targeting the neutral exopeptidases Proc.Natl.Acad.Sci.USA, 107, 2010
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8EB9
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8EBB
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4ABF
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4ABB
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4AB8
| Fragments bound to bovine trypsin for the SAMPL challenge | 分子名称: | 1,2-ETHANEDIOL, 3,4-dihydro-2H-1,5-benzodioxepin-6-ylmethanamine, CALCIUM ION, ... | 著者 | Newman, J, Peat, T.S. | 登録日 | 2011-12-08 | 公開日 | 2012-02-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The Dingo Dataset: A Comprehensive Set of Data for the Sampl Challenge. J.Comput.Aided Mol.Des., 26, 2012
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4ABD
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4ABE
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4ABG
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4ABA
| Fragments bound to bovine trypsin for the SAMPL challenge | 分子名称: | 1,2-ETHANEDIOL, 1-[2-(thiophen-2-yl)-1,3-thiazol-4-yl]methanamine, CALCIUM ION, ... | 著者 | Newman, J, Peat, T.S. | 登録日 | 2011-12-08 | 公開日 | 2012-02-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | 主引用文献 | The Dingo Dataset: A Comprehensive Set of Data for the Sampl Challenge. J.Comput.Aided Mol.Des., 26, 2012
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4ABH
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4AB9
| Fragments bound to bovine trypsin for the SAMPL challenge | 分子名称: | 1,2-ETHANEDIOL, 1-(2,3-dihydro-1-benzofuran-5-yl)methanamine, CALCIUM ION, ... | 著者 | Newman, J, Peat, T.S. | 登録日 | 2011-12-08 | 公開日 | 2012-02-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | The Dingo Dataset: A Comprehensive Set of Data for the Sampl Challenge. J.Comput.Aided Mol.Des., 26, 2012
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5UGG
| Protease Inhibitor | 分子名称: | Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide, Plasminogen | 著者 | Law, R.H.P, Wu, G, Whisstock, J.C. | 登録日 | 2017-01-08 | 公開日 | 2017-05-31 | 最終更新日 | 2020-01-08 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors. Blood Adv, 1, 2017
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5UGD
| Protease Inhibitor | 分子名称: | Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(pyridin-4-yl)methyl]-L-tyrosinamide, Plasminogen | 著者 | Law, R.H.P, Wu, G, Whisstock, J.C. | 登録日 | 2017-01-08 | 公開日 | 2017-05-31 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | 主引用文献 | X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors. Blood Adv, 1, 2017
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4DWN
| Crystal Structure of Human BinCARD CARD | 分子名称: | Bcl10-interacting CARD protein, SULFATE ION | 著者 | Chen, K.-E, Kobe, B, Martin, J.L. | 登録日 | 2012-02-26 | 公開日 | 2013-02-06 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.581 Å) | 主引用文献 | The structure of the caspase recruitment domain of BinCARD reveals that all three cysteines can be oxidized. Acta Crystallogr.,Sect.D, 69, 2013
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6NMB
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6D3Z
| Protease SFTI complex | 分子名称: | Plasminogen, Trypsin inhibitor 1 | 著者 | Law, R.H.P, Wu, G. | 登録日 | 2018-04-17 | 公開日 | 2019-01-23 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J. Med. Chem., 62, 2019
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6DLW
| Complement component polyC9 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Complement component C9, beta-D-mannopyranose | 著者 | Dunstone, M.A, Spicer, B.A, Law, R.H.P. | 登録日 | 2018-06-03 | 公開日 | 2018-09-12 | 最終更新日 | 2020-07-29 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | The first transmembrane region of complement component-9 acts as a brake on its self-assembly. Nat Commun, 9, 2018
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