6D3Y

Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma

Summary for 6D3Y

Entry DOI	10.2210/pdb6d3y/pdb
Descriptor	Plasminogen, Trypsin inhibitor 1, SULFATE ION, ... (5 entities in total)
Functional Keywords	proteases, sfti, complex, fibrinolysis, hydrolase
Biological source	Homo sapiens (Human) More
Total number of polymer chains	2
Total formula weight	28956.25
Authors	Law, R.H.P.,Wu, G. (deposition date: 2018-04-17, release date: 2019-01-23, Last modification date: 2023-10-04)
Primary citation	Swedberg, J.E.,Wu, G.,Mahatmanto, T.,Durek, T.,Caradoc-Davies, T.T.,Whisstock, J.C.,Law, R.H.P.,Craik, D.J. Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma. J. Med. Chem., 62:552-560, 2019 Cited by PubMed: 30520638 DOI: 10.1021/acs.jmedchem.8b01139 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.32 Å)

Structure validation