6D3Y
Highly Potent and Selective Plasmin Inhibitors Based on the Sunflower Trypsin Inhibitor-1 Scaffold Attenuate Fibrinolysis in Plasma
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Plasminogen | polymer | 247 | 27096.1 | 1 | UniProt (P00747) Pfam (PF00089) | Homo sapiens (Human) | microplasmin |
| 2 | B (C) | Trypsin inhibitor 1 | polymer | 14 | 1579.9 | 1 | UniProt (Q4GWU5) | Helianthus annuus | SFTI-1 |
| 3 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | D, E (C) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | F, G (A, C) | water | water | 18.0 | 174 | Chemie (HOH) |
Sequence modifications
C: 1 - 14 (UniProt: Q4GWU5)
| PDB | External Database | Details |
|---|---|---|
| Arg 7 | Ile 46 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 28676.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 280.3 | |
| All* | Total formula weight | 28956.3 |
