5UGG

Protease Inhibitor

Summary for 5UGG

• Entry DOI: 10.2210/pdb5ugg/pdb
• Related: 5UGD
• Descriptor: Plasminogen, Nalpha-[trans-4-(aminomethyl)cyclohexane-1-carbonyl]-N-octyl-O-[(quinolin-2-yl)methyl]-L-tyrosinamide (3 entities in total)
• Functional Keywords: fibrinolysis, yo, plasmin, inhibitor, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 28113.40

Authors

Law, R.H.P.,Wu, G.,Whisstock, J.C. (deposition date: 2017-01-08, release date: 2017-05-31, Last modification date: 2020-01-08)

• Primary citation: Law, R.H.P.,Wu, G.,Leung, E.W.W.,Hidaka, K.,Quek, A.J.,Caradoc-Davies, T.T.,Jeevarajah, D.,Conroy, P.J.,Kirby, N.M.,Norton, R.S.,Tsuda, Y.,Whisstock, J.C.; X-ray crystal structure of plasmin with tranexamic acid-derived active site inhibitors.; Blood Adv, 1:766-771, 2017; PubMed: 29296720; DOI: 10.1182/bloodadvances.2016004150

Experimental method

X-RAY DIFFRACTION (1.2 Å)