Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0004252 | molecular_function | serine-type endopeptidase activity |
| A | 0006508 | biological_process | proteolysis |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 19 |
| Details | binding site for residue 89M A 801 |
| Chain | Residue |
| A | GLN552 |
| A | GLY739 |
| A | ASP740 |
| A | SER741 |
| A | GLY764 |
| A | HOH983 |
| A | HOH1023 |
| A | HOH1038 |
| A | HOH1068 |
| A | HOH1082 |
| A | HOH1107 |
| A | PHE587 |
| A | CYS588 |
| A | HIS603 |
| A | LYS607 |
| A | ASP735 |
| A | SER736 |
| A | CYS737 |
| A | GLN738 |
Functional Information from PROSITE/UniProt
| site_id | PS00134 |
| Number of Residues | 6 |
| Details | TRYPSIN_HIS Serine proteases, trypsin family, histidine active site. LTAAHC |
| Chain | Residue | Details |
| A | LEU599-CYS604 | |
| site_id | PS00135 |
| Number of Residues | 12 |
| Details | TRYPSIN_SER Serine proteases, trypsin family, serine active site. DScqGDSGGPLV |
| Chain | Residue | Details |
| A | ASP735-VAL746 | |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 3 |
| Details | ACT_SITE: Charge relay system |
| Chain | Residue | Details |
| A | HIS603 | |
| A | ASP646 | |
| A | SER741 | |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | SITE: Cleavage; by plasminogen activator |
| Chain | Residue | Details |
| A | ARG561 | |
| Chain | Residue | Details |
| A | SER578 | |
| Chain | Residue | Details |
| A | SER669 | |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 425 |
| Chain | Residue | Details |
| A | HIS603 | proton shuttle (general acid/base) |
| A | ASP646 | electrostatic stabiliser, modifies pKa |
| A | SER741 | covalent catalysis, proton shuttle (general acid/base) |
| A | GLY742 | electrostatic stabiliser |
