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8UQP
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BU of 8uqp by Molmil
Escherichia coli transcription-translation coupled complex class B (TTC-B) containing RfaH bound to ops signal, mRNA with a 24 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Wang, C, Ebright, R.H.
登録日2023-10-24
公開日2024-05-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Escherichia coli transcription-translation coupled complex class A (TTC-A) containing RfaH bound to ops signal, mRNA with a 21 nt long spacer, and fMet-tRNAs in E-site and P-site of the ribosome
Nat.Struct.Mol.Biol., 2024
5UAG
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BU of 5uag by Molmil
Escherichia coli RNA polymerase mutant - RpoB D516V
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-02-08
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.399 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAQ
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BU of 5uaq by Molmil
Escherichia coli RNA polymerase RpoB H526Y mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAJ
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BU of 5uaj by Molmil
Escherichia coli RNA polymerase RpoB S531L mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.915 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAL
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BU of 5ual by Molmil
Escherichia coli RNA polymerase and Rifampin complex, RpoB S531L mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (3.887 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAC
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BU of 5uac by Molmil
Escherichia coli RNA polymerase and Rifampin complex, wild-type
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-18
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
5UAH
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BU of 5uah by Molmil
Escherichia coli RNA polymerase and Rifampin complex, RpoB D516V mutant
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Scharf, N.T, Stefan, M.A, Garcia, G.A, Murakami, K.S.
登録日2016-12-19
公開日2017-01-11
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.1 Å)
主引用文献Structural basis for rifamycin resistance of bacterial RNA polymerase by the three most clinically important RpoB mutations found in Mycobacterium tuberculosis.
Mol. Microbiol., 103, 2017
7RWI
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BU of 7rwi by Molmil
Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing TNP-2198
分子名称: (3aM,9S,10bP,14S,15R,16S,17R,18R,19R,20S,21S,25R)-6,18,20-trihydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-[2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl]-5,10,26-trioxo-3,5,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl acetate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Molodtsov, V, Ebright, R.H.
登録日2021-08-19
公開日2022-03-02
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.7 Å)
主引用文献Design, Synthesis, and Characterization of TNP-2198, a Dual-Targeted Rifamycin-Nitroimidazole Conjugate with Potent Activity against Microaerophilic and Anaerobic Bacterial Pathogens.
J.Med.Chem., 65, 2022
7U22
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BU of 7u22 by Molmil
Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7
分子名称: (9S,14S,15R,16S,17R,18R,19R,20S,21S,25R)-5,6,18,20-tetrahydroxy-14-methoxy-7,9,15,17,19,21,25-heptamethyl-1'-(2-methylpropyl)-10,26-dioxo-1,3,9,10-tetrahydrospiro[9,4-(epoxypentadecanoimino)furo[2',3':7,8]naphtho[1,2-d]imidazole-2,4'-piperidin]-16-yl benzoate, DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ...
著者Molodtsov, V, Ebright, R.H.
登録日2022-02-22
公開日2022-10-19
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.87 Å)
主引用文献Redesign of Rifamycin Antibiotics to Overcome ADP-Ribosylation-Mediated Resistance.
Angew.Chem.Int.Ed.Engl., 61, 2022
6X7K
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BU of 6x7k by Molmil
Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Ebright, R.H, Wang, C, Su, M.
登録日2020-05-30
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6X7F
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BU of 6x7f by Molmil
Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B2 (TTC-B2) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Ebright, R.H, Wang, C, Su, M.
登録日2020-05-29
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (3.5 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6XDQ
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BU of 6xdq by Molmil
Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 30 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Ebright, R.H, Wang, C, Su, M.
登録日2020-06-11
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6XGF
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BU of 6xgf by Molmil
Escherichia coli transcription-translation complex B (TTC-B) containing an 30 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Wang, C, Su, M, Ebright, R.H.
登録日2020-06-17
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (5 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6X9Q
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BU of 6x9q by Molmil
Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B3 (TTC-B3) containing an mRNA with a 27 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Ebright, R.H, Wang, C, Su, M.
登録日2020-06-03
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (4.8 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6XII
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BU of 6xii by Molmil
Escherichia coli transcription-translation complex B (TTC-B) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Wang, C, Su, M, Ebright, R.H.
登録日2020-06-20
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (7 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6X6T
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BU of 6x6t by Molmil
Cryo-EM structure of an Escherichia coli coupled transcription-translation complex B1 (TTC-B1) containing an mRNA with a 24 nt long spacer, transcription factors NusA and NusG, and fMet-tRNAs at P-site and E-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Ebright, R.H, Wang, C, Su, M.
登録日2020-05-29
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6XDR
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BU of 6xdr by Molmil
Escherichia coli transcription-translation complex B (TTC-B) containing an 27 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Wang, C, Su, M, Ebright, R.H.
登録日2020-06-11
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (4.7 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6XIJ
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BU of 6xij by Molmil
Escherichia coli transcription-translation complex A (TTC-A) containing an 24 nt long mRNA spacer, NusG, and fMet-tRNAs at E-site and P-site
分子名称: 16S rRNA, 23S rRNA, 30S ribosomal protein S1, ...
著者Molodtsov, V, Wang, C, Su, M, Ebright, R.H.
登録日2020-06-20
公開日2020-09-02
最終更新日2020-09-23
実験手法ELECTRON MICROSCOPY (8 Å)
主引用文献Structural basis of transcription-translation coupling.
Science, 369, 2020
6CUX
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BU of 6cux by Molmil
Escherichia coli RpoB S531L mutant RNA polymerase holoenzyme in complex with Kanglemycin A
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Molodtsov, V, Murakami, K.S.
登録日2018-03-26
公開日2018-07-25
最終更新日2020-01-01
実験手法X-RAY DIFFRACTION (4.104 Å)
主引用文献Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
6CUU
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BU of 6cuu by Molmil
Thermus thermophiles RNA polymerase in complex with promoter DNA and antibiotic Kanglemycin A
分子名称: DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*CP*TP*CP*TP*GP*AP*TP*GP*CP*A)-3'), DNA (5'-D(P*TP*GP*CP*AP*TP*CP*AP*GP*AP*GP*CP*CP*CP*AP*AP*AP*A)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Molodtsov, V, Murakami, K.S.
登録日2018-03-26
公開日2018-07-25
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (2.994 Å)
主引用文献Mode of Action of Kanglemycin A, an Ansamycin Natural Product that Is Active against Rifampicin-Resistant Mycobacterium tuberculosis.
Mol. Cell, 72, 2018
6TYF
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BU of 6tyf by Molmil
Crystal structure of MTB sigma L transcription initiation complex with 6 nt long RNA primer
分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*T)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Molodtsov, V, Ebright, R.H.
登録日2019-08-08
公開日2020-03-11
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3.8 Å)
主引用文献RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
6TYG
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BU of 6tyg by Molmil
Crystal structure of MTB sigma L transcription initiation complex with 9 nt long RNA primer
分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*GP*GP*TP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Molodtsov, V, Ebright, R.H.
登録日2019-08-08
公開日2020-03-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.5 Å)
主引用文献RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
6TYE
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BU of 6tye by Molmil
Crystal structure of MTB sigma L transcription initiation complex with 5 nt long RNA primer
分子名称: DNA (5'-D(*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*AP*TP*CP*GP*AP*GP*G)-3'), DNA (5'-D(P*GP*TP*GP*TP*CP*AP*GP*TP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*C)-3'), DNA-directed RNA polymerase subunit alpha, ...
著者Molodtsov, V, Ebright, R.H.
登録日2019-08-08
公開日2020-03-11
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3.79 Å)
主引用文献RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
7N4E
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BU of 7n4e by Molmil
Escherichia coli sigma 70-dependent paused transcription elongation complex
分子名称: 5'-R(*UP*UP*CP*GP*GP*AP*GP*AP*GP*GP*UP*A)-3', DNA (61-MER), DNA-directed RNA polymerase subunit alpha, ...
著者Molodtsov, V, Su, M, Ebright, R.H.
登録日2021-06-04
公開日2022-06-15
最終更新日2024-05-29
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural and mechanistic basis of sigma-dependent transcriptional pausing.
Proc.Natl.Acad.Sci.USA, 119, 2022
5W1T
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BU of 5w1t by Molmil
X-ray crystal structure of Escherichia coli RNA polymerase and DksA complex
分子名称: DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, DNA-directed RNA polymerase subunit beta', ...
著者Murakami, K.S, Molodtsov, V.
登録日2017-06-04
公開日2017-06-14
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (4.5 Å)
主引用文献Allosteric Effector ppGpp Potentiates the Inhibition of Transcript Initiation by DksA.
Mol. Cell, 69, 2018

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件を2024-06-12に公開中

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