7ZYI
 
 | | Structure of the human sodium/bile acid cotransporter (NTCP) in complex with Fab and nanobody | | 分子名称: | CHOLESTEROL, GLYCOCHENODEOXYCHOLIC ACID, Nanobody, ... | | 著者 | Liu, H, Irobalieva, R.N, Bang-Sorensen, R, Nosol, K, Mukherjee, S, Agrawal, P, Stieger, B, Kossiakoff, A.A, Locher, K.P. | | 登録日 | 2022-05-24 | | 公開日 | 2022-07-13 | | 最終更新日 | 2022-08-10 | | 実験手法 | ELECTRON MICROSCOPY (2.88 Å) | | 主引用文献 | Structure of human NTCP reveals the basis of recognition and sodium-driven transport of bile salts into the liver.
Cell Res., 32, 2022
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8A34
 | | MTH1 in complex with TH013071 | | 分子名称: | 5-(2-phenylphenyl)-1H-pyrimidine-2,4-dione, 7,8-dihydro-8-oxoguanine triphosphatase, ACETATE ION, ... | | 著者 | Liu, H, Scaletti, E, Stenmark, P. | | 登録日 | 2022-06-07 | | 公開日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | MTH1 in complex with TH013071
To Be Published
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8A0S
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8A3A
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3CYV
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4EXP
 | | Structure of mouse Interleukin-34 in complex with mouse FMS | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Interleukin-34, Macrophage colony-stimulating factor 1 receptor | | 著者 | Liu, H, Leo, C, Chen, X, Wong, B.R, Williams, L.T, Lin, H, He, X. | | 登録日 | 2012-04-30 | | 公開日 | 2012-05-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
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4EXN
 | | Crystal structure of mouse Interleukin-34 | | 分子名称: | Interleukin-34, alpha-D-mannopyranose-(1-3)-[beta-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | Liu, H, Leo, C, Chen, X, Wong, B.R, Williams, L.T, Lin, H, He, X. | | 登録日 | 2012-04-30 | | 公開日 | 2012-05-30 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | The mechanism of shared but distinct CSF-1R signaling by the non-homologous cytokines IL-34 and CSF-1.
Biochim.Biophys.Acta, 1824, 2012
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5ET0
 | | Crystal structure of Myo3b-ARB2 in complex with Espin1-AR | | 分子名称: | Espin, Myosin-IIIb | | 著者 | Liu, H, Li, J, Liu, W, Zhang, M. | | 登録日 | 2015-11-17 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
Elife, 5, 2016
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5ET1
 | | Crystal structure of Myo3b-ARB1 in complex with Espin1-AR | | 分子名称: | Espin, GLYCEROL, Myosin-IIIb | | 著者 | Liu, H, Li, J, liu, W, Zhang, M. | | 登録日 | 2015-11-17 | | 公開日 | 2016-02-03 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Myosin III-mediated cross-linking and stimulation of actin bundling activity of Espin
Elife, 5, 2016
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5ZHP
 | | M3 muscarinic acetylcholine receptor in complex with a selective antagonist | | 分子名称: | (1R,2R,4S,5S,7s)-7-({[4-fluoro-2-(thiophen-2-yl)phenyl]carbamoyl}oxy)-9,9-dimethyl-3-oxa-9-azatricyclo[3.3.1.0~2,4~]nonan-9-ium, CITRIC ACID, HEXAETHYLENE GLYCOL, ... | | 著者 | Liu, H, Hofmann, J, Fish, I, Schaake, B, Eitel, K, Bartuschat, A, Kaindl, J, Rampp, H, Banerjee, A, Hubner, H, Clark, M.J, Vincent, S.G, Fisher, J, Heinrich, M, Hirata, K, Liu, X, Sunahara, R.K, Shoichet, B.K, Kobilka, B.K, Gmeiner, P. | | 登録日 | 2018-03-13 | | 公開日 | 2018-11-28 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6C1R
 | | Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist avacopan | | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, MALONATE ION, OLEIC ACID, ... | | 著者 | Liu, H, Wang, L, Wei, Z, Zhang, C. | | 登録日 | 2018-01-05 | | 公開日 | 2018-05-30 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Orthosteric and allosteric action of the C5a receptor antagonists.
Nat. Struct. Mol. Biol., 25, 2018
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6C1Q
 | | Crystal structure of human C5a receptor in complex with an orthosteric antagonist PMX53 and an allosteric antagonist NDT9513727 | | 分子名称: | 1-(1,3-benzodioxol-5-yl)-~{N}-(1,3-benzodioxol-5-ylmethyl)-~{N}-[(3-butyl-2,5-diphenyl-imidazol-4-yl)methyl]methanamine, PMX53, Soluble cytochrome b562, ... | | 著者 | Liu, H, Wang, L, Wei, Z, Zhang, C. | | 登録日 | 2018-01-05 | | 公開日 | 2018-05-30 | | 最終更新日 | 2020-01-08 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Orthosteric and allosteric action of the C5a receptor antagonists.
Nat. Struct. Mol. Biol., 25, 2018
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7TUK
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7TUL
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3JA4
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7NA7
 | | Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist | | 分子名称: | Antibody fragment, CHOLESTEROL, Ghrelin-27, ... | | 著者 | Liu, H, Sun, D, Sun, J, Zhang, C. | | 登録日 | 2021-06-20 | | 公開日 | 2021-12-15 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
Nat Commun, 12, 2021
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7NA8
 | | Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist | | 分子名称: | 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ... | | 著者 | Liu, H, Sun, D, Sun, J, Zhang, C. | | 登録日 | 2021-06-20 | | 公開日 | 2021-12-15 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
Nat Commun, 12, 2021
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3IZO
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3JA5
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8RQF
 | | Cryo-EM structure of human NTCP-Bulevirtide complex | | 分子名称: | Fab-specific nanobody, Heavy chain of Fab3, Light chain of Fab3, ... | | 著者 | Liu, H, Zakrzewicz, D, Nosol, K, Irobalieva, R.N, Mukherjee, S, Bang-Soerensen, R, Goldmann, N, Kunz, S, Rossi, L, Kossiakoff, A.A, Urban, S, Glebe, D, Geyer, J, Locher, K.P. | | 登録日 | 2024-01-18 | | 公開日 | 2024-03-27 | | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | | 主引用文献 | Cryo-EM structure of human NTCP-Bulevirtide complex
To Be Published
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4JR7
 | | Crystal structure of scCK2 alpha in complex with GMPPNP | | 分子名称: | Casein kinase II subunit alpha, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | | 著者 | Liu, H. | | 登録日 | 2013-03-21 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
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4LFI
 | | Crystal structure of scCK2 alpha in complex with GMPPNP | | 分子名称: | Casein kinase II subunit alpha, GLYCEROL, MANGANESE (II) ION, ... | | 著者 | Liu, H. | | 登録日 | 2013-06-27 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
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4JQE
 | | Crystal structure of scCK2 alpha in complex with AMPPN | | 分子名称: | Casein kinase II subunit alpha, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | 著者 | Liu, H. | | 登録日 | 2013-03-20 | | 公開日 | 2014-03-05 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
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4MWH
 | | Crystal structure of scCK2 alpha in complex with ATP | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Casein kinase II subunit alpha, MAGNESIUM ION, ... | | 著者 | Liu, H. | | 登録日 | 2013-09-24 | | 公開日 | 2013-11-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | | 主引用文献 | The multiple nucleotide-divalent cation binding modes of Saccharomyces cerevisiae CK2 alpha indicate a possible co-substrate hydrolysis product (ADP/GDP) release pathway.
Acta Crystallogr.,Sect.D, 70, 2014
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4HGD
 | | Structural insights into yeast Nit2: C169S mutant of yeast Nit2 in complex with an endogenous peptide-like ligand | | 分子名称: | CACODYLATE ION, GLYCEROL, N-(4-carboxy-4-oxobutanoyl)-L-cysteinylglycine, ... | | 著者 | Liu, H, Qiu, X, Zhang, M, Gao, Y, Niu, L, Teng, M. | | 登録日 | 2012-10-08 | | 公開日 | 2013-07-31 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | | 主引用文献 | Structures of enzyme-intermediate complexes of yeast Nit2: insights into its catalytic mechanism and different substrate specificity compared with mammalian Nit2
Acta Crystallogr.,Sect.D, 69, 2013
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