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7CYL
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BU of 7cyl by Molmil
Crystal structure of Karyopherin-beta2 in complex with FUS PY-NLS(P525L)
分子名称: RNA-binding protein FUS, Transportin-1
著者Yoshizawa, T, Chook, Y.M.
登録日2020-09-03
公開日2021-02-24
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Mechanism of karyopherin-beta 2 binding and nuclear import of ALS variants FUS(P525L) and FUS(R495X).
Sci Rep, 11, 2021
7L5E
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BU of 7l5e by Molmil
Crystal Structure of KPT-330 bound to CRM1 (537-DLTVK-541 to GLCEQ)
分子名称: Exportin-1, GLYCEROL, GTP-binding nuclear protein Ran, ...
著者Baumhardt, J.M, Chook, Y.M.
登録日2020-12-21
公開日2021-01-27
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (1.944 Å)
主引用文献Recurrent XPO1 mutations alter pathogenesis of chronic lymphocytic leukemia.
J Hematol Oncol, 14, 2021
8F19
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BU of 8f19 by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP)
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin subunit beta-5, ...
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2025-05-28
実験手法ELECTRON MICROSCOPY (3.49 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F7A
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BU of 8f7a by Molmil
Cryo-EM structure of Importin-9 bound to RanGTP
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Importin-9, ...
著者Bernardes, N.E, Chook, Y.M.
登録日2022-11-18
公開日2023-07-26
最終更新日2025-05-14
実験手法ELECTRON MICROSCOPY (3.78 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F1E
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BU of 8f1e by Molmil
Cryo-EM structure of Kap114 bound to Gsp1 (RanGTP) and H2A-H2B
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A.2, ...
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (3.28 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
8F0X
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BU of 8f0x by Molmil
Cryo-EM structure of Kap114 bound to H2A-H2B
分子名称: Histone H2A.2, Histone H2B.2, Importin subunit beta-5
著者Jiou, J, Chook, Y.M.
登録日2022-11-04
公開日2023-07-26
最終更新日2025-05-21
実験手法ELECTRON MICROSCOPY (3.21 Å)
主引用文献Mechanism of RanGTP priming H2A-H2B release from Kap114 in an atypical RanGTP•Kap114•H2A-H2B complex.
Proc.Natl.Acad.Sci.USA, 120, 2023
2M4M
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BU of 2m4m by Molmil
Solution structure of the RRM domain of the hypothetical protein CAGL0M09691g from Candida glabrata
分子名称: hypothetical protein
著者Harris, R, Hillerich, B, Ahmed, M, Bonanno, J.B, Chamala, S, Evans, B, Lafleur, J, Hammonds, J, Washington, E, Stead, M, Love, J, Attonito, J, Patel, H, Seidel, R.D, Chook, Y.M, Rout, M.P, Girvin, M.E, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2013-02-07
公開日2013-02-27
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Solution structure of the RRM domain of the hypothetical protein CAGL0M09691g from Candida glabrata
To be Published
9B31
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BU of 9b31 by Molmil
Cryo-EM structure of yeast (Nap1)2-Kap114-H2A-H2B
分子名称: Histone H2A, Histone H2B, KAP114 isoform 1, ...
著者Jiou, J, Fung, H.Y.J, Chook, Y.M.
登録日2024-03-18
公開日2024-11-27
最終更新日2024-12-11
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.
J.Cell Biol., 224, 2025
9B3I
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BU of 9b3i by Molmil
Cryo-EM structure of yeast (Nap1)2-H2A-H2B-Kap114-RanGTP
分子名称: GTP-binding nuclear protein, GUANOSINE-5'-TRIPHOSPHATE, Histone H2A, ...
著者Fung, H.Y.J, Jiou, J, Chook, Y.M.
登録日2024-03-19
公開日2024-11-27
最終更新日2024-12-11
実験手法ELECTRON MICROSCOPY (2.88 Å)
主引用文献Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.
J.Cell Biol., 224, 2025
9B3F
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BU of 9b3f by Molmil
Cryo-EM structure of yeast (Nap1)2-H2A-H2B-Kap114
分子名称: Histone H2A, Histone H2B, KAP114 isoform 1, ...
著者Jiou, J, Fung, H.Y.J, Chook, Y.M.
登録日2024-03-19
公開日2024-11-27
最終更新日2024-12-11
実験手法ELECTRON MICROSCOPY (3.54 Å)
主引用文献Nap1 and Kap114 co-chaperone H2A-H2B and facilitate targeted histone release in the nucleus.
J.Cell Biol., 224, 2025
5YVG
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BU of 5yvg by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(full length)
分子名称: RNA-binding protein FUS, Transportin-1
著者Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
登録日2017-11-25
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (4.05 Å)
主引用文献Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
9D45
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BU of 9d45 by Molmil
Cryo-EM structure of yeast Exportin Msn5 bound to cargo Pho4 and RanGTP
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Fung, H.Y.J, Chook, Y.M.
登録日2024-08-12
公開日2025-03-19
最終更新日2025-04-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5.
Nat Commun, 16, 2025
9DXM
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BU of 9dxm by Molmil
Cryo-EM structure of yeast Exportin Msn5 bound to RanGTP and Pho4 (not modeled) (State 2-1)
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Fung, H.Y.J, Chook, Y.M.
登録日2024-10-11
公開日2025-03-19
最終更新日2025-04-02
実験手法ELECTRON MICROSCOPY (3.2 Å)
主引用文献Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5.
Nat Commun, 16, 2025
9DZ6
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BU of 9dz6 by Molmil
Cryo-EM structure of yeast Exportin Msn5 bound to RanGTP and Pho4 (not modeled) (State 3-1)
分子名称: GTP-binding nuclear protein GSP1/CNR1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ...
著者Fung, H.Y.J, Chook, Y.M.
登録日2024-10-15
公開日2025-03-19
最終更新日2025-04-02
実験手法ELECTRON MICROSCOPY (3.1 Å)
主引用文献Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5.
Nat Commun, 16, 2025
9D43
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BU of 9d43 by Molmil
Cryo-EM structure of unliganded yeast Exportin Msn5
分子名称: Protein MSN5
著者Fung, H.Y.J, Chook, Y.M.
登録日2024-08-12
公開日2025-03-19
最終更新日2025-04-02
実験手法ELECTRON MICROSCOPY (3.39 Å)
主引用文献Phosphate-dependent nuclear export via a non-classical NES class recognized by exportin Msn5.
Nat Commun, 16, 2025
5YVH
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BU of 5yvh by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(371-526)
分子名称: RNA-binding protein FUS, Transportin-1
著者Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
登録日2017-11-25
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
5YVI
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BU of 5yvi by Molmil
Crystal structure of Karyopherin beta2 in complex with FUS(456-526)
分子名称: RNA-binding protein FUS, Transportin-1
著者Yoshizawa, T, Fung, H.Y.J, Chook, Y.M.
登録日2017-11-25
公開日2018-05-16
最終更新日2023-11-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Nuclear Import Receptor Inhibits Phase Separation of FUS through Binding to Multiple Sites.
Cell, 173, 2018
4GMX
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BU of 4gmx by Molmil
Crystal structure of KPT185 in complex with CRM1-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ...
著者Sun, Q, Chook, Y.M.
登録日2012-08-16
公開日2012-10-17
最終更新日2024-10-16
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Selective inhibitors of nuclear export show that CRM1/XPO1 is a target in chronic lymphocytic leukemia.
Blood, 120, 2012
4HAW
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BU of 4haw by Molmil
Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548A)-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ...
著者Sun, Q, Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB4
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BU of 4hb4 by Molmil
Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(537DLTVK541/GLCEQ)-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ...
著者Sun, Q, Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAZ
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BU of 4haz by Molmil
Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1
分子名称: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ...
著者Sun, Q, Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAY
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BU of 4hay by Molmil
Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(K548E,K579Q)-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ...
著者Sun, Q, Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HB3
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BU of 4hb3 by Molmil
Crystal structure of CRM1(T539S)-Ran-RanBP1 with weakly bound unmodeled Leptomycin B
分子名称: CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ...
著者Sun, Q, Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4HAT
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BU of 4hat by Molmil
Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1-Ran-RanBP1
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Exportin-1, ...
著者Sun, Q, Chook, Y.M.
登録日2012-09-27
公開日2013-01-09
最終更新日2024-11-06
実験手法X-RAY DIFFRACTION (1.78 Å)
主引用文献Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110, 2013
4JLQ
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BU of 4jlq by Molmil
Crystal structure of human Karyopherin-beta2 bound to the PY-NLS of Saccharomyces cerevisiae NAB2
分子名称: Nuclear polyadenylated RNA-binding protein NAB2, Transportin-1
著者Sampathkumar, P, Gizzi, A, Rout, M.P, Chook, Y.M, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC), Nucleocytoplasmic Transport: a Target for Cellular Control (NPCXstals)
登録日2013-03-12
公開日2013-04-03
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (3.05 Å)
主引用文献Crystal structure of human Karyopherin beta 2 bound to the PY-NLS of Saccharomyces cerevisiae Nab2.
J.Struct.Funct.Genom., 14, 2013

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件を2025-07-09に公開中

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