5YK0
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8FR6
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![BU of 8fr6 by Molmil](/molmil-images/mine/8fr6) | Antibody vFP53.02 in complex with HIV-1 envelope trimer BG505 DS-SOSIP | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp120, ... | 著者 | Wang, S, Kwong, P.D. | 登録日 | 2023-01-06 | 公開日 | 2023-04-19 | 最終更新日 | 2023-06-07 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Diverse Murine Vaccinations Reveal Distinct Antibody Classes to Target Fusion Peptide and Variation in Peptide Length to Improve HIV Neutralization. J.Virol., 97, 2023
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8FLW
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8FK5
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![BU of 8fk5 by Molmil](/molmil-images/mine/8fk5) | |
8FL1
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8FEM
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![BU of 8fem by Molmil](/molmil-images/mine/8fem) | Panicum vigratum Dihydroflavonol 4-reductase complexed with NADP | 分子名称: | Dihydroflavonol 4-Reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Lewis, J.A, Kang, C. | 登録日 | 2022-12-06 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.34 Å) | 主引用文献 | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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8FEN
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![BU of 8fen by Molmil](/molmil-images/mine/8fen) | Panicum vigratum Dihydroflavonol 4-reductase complexed with NADP and DHQ | 分子名称: | (2R,3R)-2-(3,4-DIHYDROXYPHENYL)-3,5,7-TRIHYDROXY-2,3-DIHYDRO-4H-CHROMEN-4-ONE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Panicum virgatum Dihydroflavonol 4-Reductase | 著者 | Lewis, J.A, Kang, C. | 登録日 | 2022-12-06 | 公開日 | 2023-09-20 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Structural Similarities and Overlapping Activities among Dihydroflavonol 4-Reductase, Flavanone 4-Reductase, and Anthocyanidin Reductase Offer Metabolic Flexibility in the Flavonoid Pathway. Int J Mol Sci, 24, 2023
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4YFL
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![BU of 4yfl by Molmil](/molmil-images/mine/4yfl) | Crystal structure of VH1-46 germline-derived CD4-binding site-directed antibody 1B2530 in complex with HIV-1 clade A/E 93TH057 gp120 | 分子名称: | 1B2530 Light chain, 1B2530 heavy chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Acharya, P, Zhou, T, Moquin, S, Kwong, P.D. | 登録日 | 2015-02-25 | 公開日 | 2015-06-03 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.387 Å) | 主引用文献 | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
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6XCJ
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![BU of 6xcj by Molmil](/molmil-images/mine/6xcj) | Crystal Structure of DH650 Fab from a Rhesus Macaque in Complex with HIV-1 gp120 Core | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DH650 Fab Heavy Chain, DH650 Fab Light Chain, ... | 著者 | Raymond, D.D, Chug, H, Harrison, S.C. | 登録日 | 2020-06-08 | 公開日 | 2020-12-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Recapitulation of HIV-1 Env-antibody coevolution in macaques leading to neutralization breadth. Science, 371, 2021
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4YDI
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![BU of 4ydi by Molmil](/molmil-images/mine/4ydi) | Crystal structure of broad and potently neutralizing VRC01-class antibody Z258-VRC27.01, isolated from human donor Z258, in complex with HIV-1 gp120 from clade A strain Q23.17 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein gp160, ... | 著者 | Zhou, T, Srivatsan, S, Kwong, P.D. | 登録日 | 2015-02-22 | 公開日 | 2015-06-03 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.452 Å) | 主引用文献 | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
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6BR9
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![BU of 6br9 by Molmil](/molmil-images/mine/6br9) | Structure of A6 reveals a novel lipid transporter | 分子名称: | (1R)-2-{[{[(2S)-2,3-DIHYDROXYPROPYL]OXY}(HYDROXY)PHOSPHORYL]OXY}-1-[(PALMITOYLOXY)METHYL]ETHYL (11E)-OCTADEC-11-ENOATE, Protein A6 homolog, [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate | 著者 | Deng, J, Peng, S, Pathak, P. | 登録日 | 2017-11-30 | 公開日 | 2018-06-20 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structure of a lipid-bound viral membrane assembly protein reveals a modality for enclosing the lipid bilayer. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6XDG
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![BU of 6xdg by Molmil](/molmil-images/mine/6xdg) | Complex of SARS-CoV-2 receptor binding domain with the Fab fragments of two neutralizing antibodies | 分子名称: | REGN10933 antibody Fab fragment heavy chain, REGN10933 antibody Fab fragment light chain, REGN10987 antibody Fab fragment heavy chain, ... | 著者 | Franklin, M.C, Saotome, K, Romero Hernandez, A, Zhou, Y. | 登録日 | 2020-06-10 | 公開日 | 2020-06-24 | 最終更新日 | 2021-01-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Studies in humanized mice and convalescent humans yield a SARS-CoV-2 antibody cocktail. Science, 369, 2020
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4YE4
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![BU of 4ye4 by Molmil](/molmil-images/mine/4ye4) | Crystal Structure of Neutralizing Antibody HJ16 in Complex with HIV-1 gp120 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, HT593.1 gp120, Heavy chain human antibody HJ16, ... | 著者 | Kwong, P.D, Chen, L, Zhou, T. | 登録日 | 2015-02-23 | 公開日 | 2015-07-22 | 最終更新日 | 2022-03-30 | 実験手法 | X-RAY DIFFRACTION (2.72 Å) | 主引用文献 | Structural Repertoire of HIV-1-Neutralizing Antibodies Targeting the CD4 Supersite in 14 Donors. Cell, 161, 2015
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6A2B
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![BU of 6a2b by Molmil](/molmil-images/mine/6a2b) | Crystal Structure of Xenopus laevis MHC I complex | 分子名称: | Beta-2-microglobulin, MHC class I antigen, TYR-MET-MET-PRO-ARG-HIS-TRP-PRO-ILE | 著者 | Ma, L.Z, Xia, C. | 登録日 | 2018-06-10 | 公開日 | 2019-10-23 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | A Glimpse of the Peptide Profile Presentation byXenopus laevisMHC Class I: Crystal Structure of pXela-UAA Reveals a Distinct Peptide-Binding Groove. J Immunol., 204, 2020
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5WXH
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![BU of 5wxh by Molmil](/molmil-images/mine/5wxh) | Crystal structure of TAF3 PHD finger bound to H3K4me3 | 分子名称: | Histone H3K4me3, Transcription initiation factor TFIID subunit 3, ZINC ION | 著者 | Zhao, S, Huang, J, Li, H. | 登録日 | 2017-01-07 | 公開日 | 2017-08-16 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (1.297 Å) | 主引用文献 | Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5WXG
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![BU of 5wxg by Molmil](/molmil-images/mine/5wxg) | Structure of TAF PHD finger domain binds to H3(1-15)K4ac | 分子名称: | Histone H3K4ac, MAGNESIUM ION, Transcription initiation factor TFIID subunit 3, ... | 著者 | Zhao, S, Li, H. | 登録日 | 2017-01-07 | 公開日 | 2017-08-16 | 最終更新日 | 2017-09-13 | 実験手法 | X-RAY DIFFRACTION (1.703 Å) | 主引用文献 | Kinetic and high-throughput profiling of epigenetic interactions by 3D-carbene chip-based surface plasmon resonance imaging technology Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7NCW
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7ELG
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![BU of 7elg by Molmil](/molmil-images/mine/7elg) | LC3B modificated with a covalent probe | 分子名称: | 2-methylidene-5-thiophen-2-yl-cyclohexane-1,3-dione, Microtubule-associated proteins 1A/1B light chain 3B, SULFATE ION | 著者 | Fan, S, Wan, W. | 登録日 | 2021-04-10 | 公開日 | 2021-10-13 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.599 Å) | 主引用文献 | Inhibition of Autophagy by a Small Molecule through Covalent Modification of the LC3 Protein. Angew.Chem.Int.Ed.Engl., 60, 2021
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8JT8
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![BU of 8jt8 by Molmil](/molmil-images/mine/8jt8) | Crystal structure of 5-HT2AR in complex with (R)-IHCH-7179 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, 5-hydroxytryptamine receptor 2A,Soluble cytochrome b562, ... | 著者 | Chen, Z, Fan, L, Wang, S. | 登録日 | 2023-06-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187, 2024
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8JT6
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![BU of 8jt6 by Molmil](/molmil-images/mine/8jt6) | 5-HT1A-Gi in complex with compound (R)-IHCH-7179 | 分子名称: | 1-(4-fluorophenyl)-4-[(7R)-2,5,11-triazatetracyclo[7.6.1.0^2,7.0^12,16]hexadeca-1(15),9,12(16),13-tetraen-5-yl]butan-1-one, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Chen, Z, Xu, P, Huang, S, Xu, H.E, Wang, S. | 登録日 | 2023-06-21 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Flexible scaffold-based cheminformatics approach for polypharmacological drug design. Cell, 187, 2024
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6MTS
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![BU of 6mts by Molmil](/molmil-images/mine/6mts) | Crystal structure of VRC43.03 Fab | 分子名称: | Antibody VRC43.03 Fab heavy chain, Antibody VRC43.03 Fab light chain | 著者 | Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Doria-Rose, N.A, Kwong, P.D. | 登録日 | 2018-10-21 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.437 Å) | 主引用文献 | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
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5Y4O
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![BU of 5y4o by Molmil](/molmil-images/mine/5y4o) | Cryo-EM structure of MscS channel, YnaI | 分子名称: | Low conductance mechanosensitive channel YnaI | 著者 | Zhang, Y, Yu, J. | 登録日 | 2017-08-04 | 公開日 | 2019-03-20 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | A binding-block ion selective mechanism revealed by a Na/K selective channel. Protein Cell, 9, 2018
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6MTT
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![BU of 6mtt by Molmil](/molmil-images/mine/6mtt) | Crystal structure of VRC46.01 Fab in complex with gp41 peptide | 分子名称: | Antibody VRC46.01 Fab heavy chain, Antibody VRC46.01 Fb light chain, RV217 founder virus gp41 peptide | 著者 | Kwon, Y.D, Druz, A, Law, W.H, Peng, D, Veradi, R, Doria-Rose, N.A, Kwong, P.D. | 登録日 | 2018-10-21 | 公開日 | 2019-03-27 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
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6MTQ
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![BU of 6mtq by Molmil](/molmil-images/mine/6mtq) | Crystal structure of VRC42.N1 Fab in complex with T117-F MPER scaffold | 分子名称: | Antibody VRC42.N1 Fab heavy chain, Antibody VRC42.N1 Fab light chain, VRC42 epitope T117-F scaffold | 著者 | Kwon, Y.D, Law, W.H, Veradi, R, Doria-Rose, N.A, Kwong, P.D. | 登録日 | 2018-10-21 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | Longitudinal Analysis Reveals Early Development of Three MPER-Directed Neutralizing Antibody Lineages from an HIV-1-Infected Individual. Immunity, 50, 2019
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8DEQ
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![BU of 8deq by Molmil](/molmil-images/mine/8deq) | Cryo-EM local refinement of antibody SKV09 in complex with VEEV alphavirus spike glycoprotein | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, SKV09 Fab Heavy Chain, SKV09 Fab Light Chain, ... | 著者 | Casner, R.G, Verardi, R, Roederer, M, Shapiro, L. | 登録日 | 2022-06-21 | 公開日 | 2023-06-28 | 実験手法 | ELECTRON MICROSCOPY (6 Å) | 主引用文献 | Vaccine elicitation and structural basis for antibody protection against alphaviruses. Cell, 186, 2023
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